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Description	Biochem/physiol Actions	Product #
S-(5′-Adenosyl)-L-homocysteine Hydrolase from rabbit erythrocytes buffered aqueous glycerol solution, ≥10 units/mg protein (Lowry)	Enzyme in vertebrates which catabolizes S-adenosyl-L-homocysteine.	A1705
5-Azacytidine ≥98% (HPLC)	A potent growth inhibitor and cytotoxic agent; inhibits DNA methyltransferase, an important regulatory mechanism of gene expression, gene activation and silencing. Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes.	A2385
5-Aza-2′-deoxycytidine ≥97%	5'-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.	A3656
Bay 11-7082 ≥98% (HPLC), solid	Bay 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation.	B5556
Bay 11-7085 ≥98% (HPLC), solid	Inhibits NF-κB activated expression of ICAM-1, VCAM-1, E-selectin, IL-6 and IL-8.	B5681
Bicalutamide (CDX) ≥98% (HPLC), powder	Bicalutamide (CDX) is a non-steriodal Androgen Receptor (AR) antagonist and a pure antiandrogen. It acts via balancing histone acetylation/deacetylation and recruitment of coregulators. Bicalutamide (CDX) abolishes androgen-mediated expression. For example, MMP13 upregulation in prostate cancer, PLZF (promyelocytic leukemia zinc finger protein), and GADD45γ (growth arrest and DNA damage inducible, gamma). Bicalutamide (CDX) is inhibited by non-genomic, transcription-independent stimulation of PI3K/AKT phosphorylation by androgens.	B9061
Caffeic acid phenethyl ester ≥97% (HPLC), powder	Caffeic acid phenethyl ester (CAPE) is the active component of propolis, a honeybee hive product.¹ Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor, NF-κB.² CAPE has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.^3,⁴ Caffeic acid phenethyl ester inhibits HIV-1 integrase,^5,⁶ and also inhibits proliferation of transformed cells.^7,⁸ It induces apoptosis in transformed fibroblasts,⁹ and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.⁷	C8221
Cambinol ≥97% (HPLC), wet powder	Cambinol is a Sirtuin (Human Silent Information Regulator) Type 1/2 Inhibitor. Sirtuins are structurally and mechanistically unrelated to HDACs Class 1 & 2 deacetylases but share many protein targets. HDAC is a large complex enzyme family involved in epigenetic-control of gene expression. Sirt2 has an IC₅₀ equal to 59 μM.	C0494
Cholecalciferol meets USP testing specifications	Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.	C1357
3,3'-Diindolylmethane	3,3'-Diindolylmethane (DIM) is an acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol.¹ It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells.^2,³ DIM induces a G(1) cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H(+)-ATPase inhibitor.⁴ The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system.⁵	D9568
Monoclonal Anti-5MTH Folic Acid antibody produced in mouse clone FA-24, ascites fluid		M5028
25-Hydroxycholecalciferol 98% (HPLC)		H4014
Methoprene acid ≥98% (TLC)		M6682
NFAT Inhibitor >96% (HPLC), solid	High-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.	N7032
Psammaplin A ≥97% (HPLC), solid	Psammaplin A is an antibiotic, anti-tumor, DNA methyltransferase inhibitor. It is a bromotyrosine-derived, symmetrical conjugate of cystamine, which was first isolated from the Psammaplinaplysilla sponge. Psammaplin A impedes angiogenesis as well as bacterial and tumor cell growth. Psammaplin A inhibits the activities of several key enzymes in prokaryotic and eukaryotic systems including those involved in epigenetic control of gene expression, DNA replication, angiogensis, and microbial detoxification.	P8749
Sinefungin 95% (HPLC), powder	Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N⁶-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis. Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N⁶-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis. Methylation inhibition by sinefugin is often accompanied by an altered rate of cytosine deamination that is coupled to transition mutation in the DNA. Sinefugin inhibits Epstein-Barr viral activity and this inhibition is related to the change in DNA methylation and gene expression. It can cause a rate change in several restriction DNA endonuclease activities, including Mme I, which is not connected to the inhibition of the methytransferase activity.	S8559
Monoclonal Anti-Vitamin D Receptor antibody produced in rat ~1 mg/mL, clone 9A7g.E10.E4, purified immunoglobulin, buffered aqueous solution		V9513

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