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Metabotropic Agonists

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Image	Description	Biochem/physiol Actions	CAS Number	Product #
	(2S,1′S,2′S)-2-(Carboxycyclopropyl)glycine solid	Potent group II metabotropic glutamate receptor agonist.	117857-93-9	C237
	(S)-3,5-Dihydroxyphenylglycine hydrate ≥98% (HPLC), solid	(S)-3,5-Dihydroxyphenylglycine hydrate is a group I metabotropic glutamate receptor agonist.		D3689
	L-(+)-2-Amino-4-phosphonobutyric acid optical purity optical purity: ≥95% (HPLC, Marfey's reagent)	mGluR₄ and mGluR₆ metabotropic glutamate receptor agonist.	23052-81-5	A7929
	AMN082 ≥98% (HPLC), solid	AMN082 is a selective allosteric mGluR 7 receptor agonist and first selective pharmacological tool for mGluR7. AMN082 inhibits forskolin-stimulated cAMP accumulation (EC₅₀ = 64 nM) and stimulates GTPγS binding (EC₅₀ = 290 nM) similar to L-AP₄ and greater than L-glutamate. Thus, AMN082 is a “full agonist” and acts at an allosteric site in the transmembrane domain of mGluR7. AMN082 has no effects at other mGluR's up to 10 μM and stimulates release of stress hormones (corticosterone and ACTH) and is orally active and brain penetrable.	97075-46-2	A6605
	O-Phospho-L-serine	Group III metabotropic glutamate receptor agonist (mGluR₄, mGluR₇, and mGluR₈).	407-41-0	P0878
	PBDA >95% (NMR), liquid		229472-51-9	P2238
	trans-(±)-ACPD monohydrate solid, ≥97% (NMR)	Excitatory amino acid receptor agonist; selective for the metabotropic glutamate receptor subtype.	67684-64-4 (anhydrous)	A155
	trans-(1S,3R)-ACPD >97%, solid	Selective metabotropic glutamate receptor agonist; active enantiomer of trans-(±)-ACPD.	111900-32-4	A182

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