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AMPA/Kainate Antagonists

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Image	Description	Biochem/physiol Actions	CAS Number	Product #
	(2S,4R)-4-Methylglutamic acid solid	Selective and high affinity kainate receptor antagonist.	31137-74-3	G137
	1-Naphthylacetyl spermine trihydrochloride >97%, solid, ≥98% (HPLC)	Blocks Ca²⁺ permeable AMPA receptor channels.		N193
	ATPO solid	Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.	252930-37-3	A7845
	CNQX disodium salt solid	Potent, competitive AMPA/kainate receptor antagonist.		C239
	CNQX ≥98% (HPLC), solid	Potent, competitive AMPA/kainate glutamate receptor antagonist.	115066-14-3	C127
	Caroverine hydrochloride ≥98% (HPLC), solid	Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist. Also, Caroverine hydrochloride is a class B calcium-channel-blocker, antiglutamatergic agent, and acts as an antioxidant when administered to lab animals.	55750-05-5	C1119
	DNQX ~98%	A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.	2379-57-9	D0540
	Dihydrokainic acid ≥97% (NMR), solid	Dihydrokainic acid is a selective inhibitor of the GLT-1 glutamate transporter. At higher concentrations, dihydrokainate is a weak inhibitor of AMPA/kainate glutamic acid receptors.	52497-36-6	D1064
	GYKI 52466 hydrochloride solid	Selective allosteric AMPA receptor antagonist; anticonvulsant; skeletal muscle relaxant.	192065-56-8	G119
	IEM-1460 solid	Selective inhibitor of a subtype of AMPA receptors (Ca²⁺ permeable, lacking GluR2 subunits); tool for functionally discriminating between AMPA receptors of different subunit composition	121034-89-7	I0154
	Kynurenic acid ≥98%	Kynurenic acid is a non-selective antagonist at NMDA and AMPA/kainate receptors; blocks kainic acid neurotoxicity. Kainic acid also blocks nicotinic acetycholine receptors (J. Neuroscience, 2001)	492-27-3	K3375
	L-β-threo-benzyl-aspartate ammonium salt ≥98% (HPLC), solid	L-β-threo-benzyl-aspartate is a preferential EAAT3 excitatory amino acid transporter antagonist. The product exhibits 10-fold selectivity for EAAT3, Ki = 0.8 μM for EAAT3 in C17.2 neuroprogenitor cells expressing hEAATs (vs. Ki of 8.7 μM for EAAT1 and Ki of 10 µM for EAAT2). L-β-threo-benzyl-aspartate is a useful tool for studying the EAAT2 pharmacophore.	871123-98-7 (free acid)	B6436
	NBQX disodium salt hydrate ≥98% (HPLC), solid	NBQX disodium salt hydrate is a neuroprotective AMPA/kainate glutamate receptor antagonist.	118876-58-7 (free acid)	N183
	NBQX hydrate solid, ≥98% (HPLC)	Neuroprotective AMPA/kainate glutamate receptor antagonist.	118876-58-7 (anhydrous)	N171
	NS 102 solid	Competitive glutamate receptor antagonist with high selectivity for the low-affinity [³H] kainate binding site.	136623-01-3	N179
	γ-D-Glutamylaminomethylsulfonic acid solid	Selective antagonist at AMPA/kainate glutamatergic receptors; anticonvulsant.	90237-02-8	G111

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