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Glycinergics

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Image	Description	Biochem/physiol Actions	CAS Number	Product #
	D-Serine ≥98% (TLC)	Glycine mimic active at the strychnine-insensitive glycine binding site associated with the NMDA receptor as well as the inhibitory post-synaptic glycine receptor.	312-84-5	S4250
	L-Serine ReagentPlus^®, ≥99% (TLC)	Precursor of glycine by serine hydroxymethyltransferase.	56-45-1	S4500
	ALX 5407 hydrochloride >98% (HPLC), solid	Selective, irreversible GlyT-1 glycine transporter inhibitor.		A8977
	ALX-1393 >98% (HPLC), powder	GlyT-2 glycine transporter inhibitor.		A5475
	Glycine hydrochloride ≥99% (TLC)	Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.	6000-43-7	G2879
	Glycine sodium salt ≥99% (TLC)	Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.	6000-44-8	G6761
	Glycine ReagentPlus^®, ≥99% (TLC)	Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.	56-40-6	G7126
	Hypotaurine ≥98% (TLC), powder	Antioxidant that binds hydroxyl radicals. Endogenous inhibitory neuromodulator that is blocked by strychnine and picrotoxin. Inhibits the Na²⁺-dependent transport of GABA and β-alanine. It is a degradation product of cysteine and a precursor of taurine.	300-84-5	H1384
	Org 24598 lithium salt ≥98% (HPLC), solid	Org 24598 is a selective, potent inhibitor of glial GlyT (GlyT1, glycine transporter type 1). In rats (P12-P16) and in the presence of kynurenic acid, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and bicuculline, ORG 24598 at a concentration of 10 μM induced a mean inward current of -10/-50 pA at -60 mV and increased significantly the decay time constants of miniature (mIPSCs), spontaneous (sIPSCs) and electrically evoked glycinergic (eIPSCs) inhibitory postsynaptic currents. Replacing extracellular sodium with N-methyl-d-glucamine or superfusing the slice with micromolar concentrations of glycine also increased the decay time constant of glycinergic IPSCs. Glycine (1-5 μM and d-serine (10 μM) increased the amplitude of eEPSCs whereas l-serine had no effect. Org 24598 increased significantly the amplitude of NMDA receptor-mediated eEPSCs without affecting the amplitude of non-NMDA receptor-mediated eEPSCs. This brings conclusion that blocking glial glycine transporter by Org 24598 increased the level of glycine in spinal cord slices, which in turn prolonged the duration of glycinergic synaptic current and potentiated the NMDA-mediated synaptic response.	722456-08-8	O7639
	Phenylbenzene ω-phosphono-α-amino acid solid	Selective strychnine-sensitive glycine receptor antagonist.		P204
	Strychnine	Convulsant; glycine receptor antagonist not associated with the NMDA receptor.	57-24-9	S0532
	Strychnine hydrochloride	Convulsant; glycine receptor antagonist not associated with the NMDA receptor.	1421-86-9	S8753
	Taurine ≥99%	Non-selective endogenous agonist at glycine receptors. Conditionally essential sulfonated amino acid which modulates apoptosis in some cells; functions in many metabolic activities; a product of methionine and cysteine metabolism.	107-35-7	T0625
	Tetanus toxin C fragment from Clostridium tetani			T3694
	Tetanus toxin C-fragment−FITC from Clostridium tetani	C terminal portion conjugated to fluorescein isothiocyanate is taken up by persynaptic nerve terminals and exhibits transsynaptic retrograde transport in central neurons similar to that of tetanus toxin. It is used to map neuronal connections and to target proteins to neurons		T3819
	Tetanus toxin from Clostridium tetani	Binds to polysialogangliosides acceptors on surface of all peripheral presynaptic nerve terminals. Internalized by receptor-mediated endocytosis and carried to spinal cord and brain by transsynaptic retrograde transport. Blocks the release of glycine from inhibitory interneurons of the spinal cord. Cleaves synaptobrevin (VAMP-2), and blocks synaptic vesicle exocytosis in vivo.	676570-37-9	T3194
	β-Alanine 99%	Endogenous β-amino acid that is a nonselective agonist at glycine receptors and a ligand for the G protein-coupled orphan receptor, TGR7 (MrgD). β-alanine flux plays a cytoprotective role by supporting the osmotic stability of marine organisms, preimplantation mouse embryos and mammalian cells exposed to hypoxic stress.	107-95-9	146064

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