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Antagonists

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CAS Number
Product #
3-Tropanylindole-3-carboxylate methiodide solid Potent, water soluble 5-HT3 serotonin receptor antagonist.
 115626-53-4 T113
Altanserin hydrochloride hydrate ≥98% (HPLC), solid Altanserin hydrochloride hydrate is a specific 5HT2/serotonergic antagonist.
 76330-71-7 (free base) A8106
BRL 15572 Potent and selective 5-HT1D serotonin receptor antagonist.
 B9929
Clozapine N-oxide 5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.
 34233-69-7 C0832
Cyclobenzaprine hydrochloride Skeletal muscle relaxant; reduces muscle spasm by depression of brainstem neurons; 5-HT2 serotonin receptor antagonist.
 6202-23-9 C4542
Cyproheptadine hydrochloride sesquihydrate ≥98% (TLC), solid 5-HT2/5-HT1C serotonin receptor antagonist; H1 histamine receptor antagonist; antipruritic.
 41354-29-4 C6022
GR 113808 solid, >98% (HPLC) 5-HT4 serotonin receptor antagonist.
 144625-51-4 G5918
GR 127935 hydrochloride hydrate >98% (HPLC), solid Potent, selective and orally active 5-HT1B/1D serotonin receptor antagonist.
 148642-42-6 (anhydrous) G5793
GR 55562 dihydrobromide >97% (HPLC), powder 5-HT1B/5-HT1D serotonin receptor antagonist
 172854-55-6 G0419
Granisetron hydrochloride ≥98% (HPLC), solid Granisetron hydrochloride is a serotonin 5-HT3 receptor antagonist and antiemetic.
 107007-99-8 G3796
Ketanserin (+)-tartrate salt >97%, solid Selective 5-HT2 serotonin receptor antagonist.
 83846-83-7 S006
LY-310,762 hydrochloride white powder Potent, selective 5-HT1D serotonin receptor antagonist.
 L2536
LY-367,265 Antidepressant, inhibits the serotonin transporter; 5-HT2A serotonin receptor antagonist.
 L2411
Metergoline Antagonist at 5-HT1, 5-HT2, and 5-HT7 serotonin receptors; analgesic; antipyretic.
 17692-51-2 M3668
Methiothepin mesylate salt ≥98% (HPLC), solid Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
 74611-28-2 M149
Methysergide maleate salt solid Nonselective 5-HT1, 5-HT2, and 5-HT7 serotonin receptor antagonist; antimigraine.
 129-49-7 M137
Mianserin hydrochloride Antidepressant; antagonist/inverse agonist at 5-HT2 serotonin receptors; also blocks the H1 histamine receptor and the α2 adrenoceptor.
 21535-47-7 M2525
Mosapride citrate dihydrate New 5-HT4 receptor agonist and 5-HT3 receptor antagonist
 636582-62-2 M2946
N-Desmethylclozapine Major metabolite of clozapine; potent 5-HT2 serotonin receptor antagonist and a ligand for the cloned 5-HT6 and 5-HT7 serotonin receptors. Also an allosteric potentiator of M1 muscarinic receptors.
 6104-71-8 D5676
NAN-190 hydrobromide Potent 5-HT1A serotonin receptor antagonist active in the nM range.
 115338-32-4 N3529
Ondansetron hydrochloride dihydrate ≥98% (HPLC), solid 5-HT3 serotonin receptor antagonist
 103639-04-9 O3639
Pipamperone dihydrochloride ~99% (HPLC), powder D2 dopamine receptor antagonist; 5-HT2 serotonin receptor antagonist; antipsychotic.
 2448-68-2 P3246
Pirenperone >97%, solid 5-HT2 serotonin receptor antagonist.
 75444-65-4 P126
Risperidone ≥98% (HPLC), powder Risperidone is an antipsychotic; serotonin-dopamine antagonist.
 106266-06-2 R3030
Ritanserin solid Potent 5-HT2A serotonin receptor antagonist/inverse agonist that crosses the blood-brain barrier.
 87051-43-2 R103
Ro 04-6790 dihydrochloride solid Selective 5-HT6 serotonin receptor antagonist.
 202466-68-0 R140
S(−)-Cyanopindolol hemifumarate salt solid, ≥98% (HPLC) 5-HT1A/1B serotonin receptor antagonist; β3-adrenoceptor antagonist.
 874882-72-1 C238
S(−)-UH-301 hydrochloride solid Potent, selective 5-HT1A serotonin receptor antagonist; D2/D3 dopamine receptor agonist.
 127126-22-1 U108
SB 204741 >98% (HPLC) 5-HT2B serotonin receptor antagonist.
 152239-46-8 S0693
SB-200646 hydrochloride >98% (HPLC), solid 5-HT2C/2B serotonin receptor antagonist.
 143797-62-0 S0568
SB-203186 99% (HPLC) 5-HT4 serotonin receptor antagonist.
 135938-17-9 S0443
SB-204070 hydrochloride solid, ≥97% (HPLC) Selective 5-HT4 serotonin receptor antagonist.
 148702-58-3 S3313
SB-206553 hydrochloride hydrate ≥98% (HPLC), solid Potent 5-HT2B/5-HT2C serotonin receptor antagonist.
 158942-04-2 (free base) S180
SB-215505 solid, >98% (HPLC) Selective 5-HT2B serotonin receptor antagonist; 100-fold higher affinity at 2B versus 2C.
 162100-15-4 S1068
SB-216641 ≥99% (HPLC), solid 5-HT1B serotonin receptor antagonist
S8942
SB-221284 >98% (HPLC), solid 5-HT2B/2C serotonin receptor antagonist.
 196965-14-7 S2193
SB-224289 hydrochloride solid Selective 5-HT1B serotonin receptor antagonist.
 180084-26-8 S201
SB-258585 dihydrochloride ~99% (HPLC), solid 5-HT6 serotonin receptor antagonist.
 S1194
SB-269970 hydrochloride solid, ≥98% (HPLC) Selective 5-HT7 serotonin receptor antagonist.
 261901-57-9 S7389
SB 242084 dihydrochloride hydrate ≥98% (HPLC), solid Selective 5-HT2c serotonin receptor antagonist; crosses the blood-brain barrier.
 181632-25-7 (free base) S8061
SDZ-205,557 hydrochloride solid Potent, selective 5-HT4 serotonin receptor antagonist.
 137196-67-9 S174
Sertindole ≥97.5% (HPLC) Sertindole is a 5-HT2 serotonin and D2 dopamine receptor antagonist and antipsychotic.
 106516-24-9 S8072
Spiroxatrine powder Partial 5-HT1A serotonin receptor agonist and α adrenoceptor antagonist.
 1054-88-2 S103
Tropisetron monohydrochloride solid, ≥98% (HPLC) 3-Tropanylindole-3-carboxylate hydrochloride is a selective 5-HT3 serotonin receptor antagonist.
Tropisetron a selective serotonin 5-HT3 receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.
 105826-92-4 T104
WAY-100635 maleate salt solid WAY-100635 maleate salt is a highly selective 5-HT1A serotonin receptor antagonist.
 634908-75-1 W108
Ziprasidone hydrochloride monohydrate ≥98% (HPLC), solid New Ziprasidone is an atypical antipsychotic; FDA approved for the treatment of schizophrenia.
 138982-67-9 Z2777
p-MPPF dihydrochloride solid Selective 5-HT1A serotonin receptor antagonist. More potent than p-MPPI.
 M226