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Immunomodulators and Antibiotics

Description
Biochem/physiol Actions
Product #
Acetyl-Cys(dodecyl) chloromethyl ketone ≥90% (HPLC), solid Potent cytotoxic chloromethylketone against human-lineage and T-lineage acute lymphoblastic leukemia cell lines
 A9346
Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt ≥98% (HPLC), solid PAR4 receptor agonist peptide.
 A3227
Ascomycin from Streptomyces hygroscopicus var. ascomyceticus Strong immunosuppressant; inhibits allogenic T-lymphocyte proliferation. It binds with high affinity to FKBP and inhibits calcineurin phosphatase in the nM range.
 A3835
Beclomethasone ≥99% An anti-inflammatory glucocorticoid.
 B0385
Borrelidin from Streptomyces sp., ≥95% (HPLC), lyophilized powder Borrelidin, an 18-membered macrolide-polyketide, is a compound with anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic properties. It is a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetases. Borrelidin induces apoptosis in endothelial cells via the caspase 3 and caspase 8 pathway. In addition, borrelidin strongly inhibits capillary tube formation and also disrupts formed capillary tubes by inducing apoptosis of the tube-forming cells in a rat aorta matrix culture model. In S.cerevisiae, borrelidin inhibits the cyclin-dependent kinase Cdc28/Cln2 with an IC50 of 24 μM, causing the arrest of both haploid and diploid cells in G1 phase and inducing the transcription of amino acid biosynthetic enzymes through a GCN4-dependent pathway.
 B1936
Borrelidin from Streptomyces parvulus, ≥98% (HPLC) Borrelidin, an 18-membered macrolide-polyketide, is a compound with anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic properties. It is a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetases. Borrelidin induces apoptosis in endothelial cells via the caspase 3 and caspase 8 pathway. In addition, borrelidin strongly inhibits capillary tube formation and also disrupts formed capillary tubes by inducing apoptosis of the tube-forming cells in a rat aorta matrix culture model. In S.cerevisiae, borrelidin inhibits the cyclin-dependent kinase Cdc28/Cln2 with an IC50 of 24 μM, causing the arrest of both haploid and diploid cells in G1 phase and inducing the transcription of amino acid biosynthetic enzymes through a GCN4-dependent pathway.
 B3061
Budesonide ≥99% Budesonide is a second generation glucocorticoid with low systemic absorption. It is used as an anti-inflammatory agent in the treatment of asthma, rhinitis, and inflammatory bowel disease. It inhibits the expression of chemokine mRNA and production of eotaxin and RANTES protein in primary human bronchial epithelial cells. Budesonide is currently in clinical trials for the prevention of lung cancer. It shows inhibitory effects on benzo[a]pyrene-induced carcinogenesis of the lung in mice.
B7777
Carboxypeptidase A Assay Kit sufficient for 200 assays (96-well plates), sufficient for 40 assays (1 mL cuvettes) New CS1130
Cardiogenol C hydrochloride ≥97% (HPLC), solid Cardiomyogenesis inducer in embryonic stem cells.
 C4866
Cecropin A ≥97% (HPLC), powder Antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine.
 C6830
Cecropin B ≥97% (HPLC), powder Antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine.
 C1796
Cecropin P1 Porcine ≥95% (HPLC), powder Antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine.
 C7927
Chymase human recombinant, expressed in Pichia pastoris New C8118
Chymase Activity Assay Kit sufficient for 150 assays (100 μL), sufficient for 30 assays (1 mL) New CS1140
Cromolyn sodium salt ≥95% C0399
Curdlan from Alcaligenes faecalis Polysaccharide possessing immunomodulatory activity.
 C7821
Cyclosporin A from Tolypocladium inflatum, ≥95% (HPLC), solid A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
 C3662
Cyclosporin A from Tolypocladium inflatum, for molecular biology, ≥95% A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
Potent immunosuppressive agent, inhibiting primarily T lymphocytes.
 C1832
β-Defensin 1 human ≥98% (HPLC and SDS-PAGE), recombinant, expressed in Escherichia coli, lyophilized powder (from 10 mM acetic acid) A small cationic peptide which demonstrates anti-microbial activity. Originally isolated from human plasma, this substance is constitutively expressed in mucosal membrane epithelium.
 D9565
β-Defensin 2 human recombinant, expressed in Escherichia coli, lyophilized powder (from 10 mM acetic acid) A small cationic peptide which demonstrates anti-microbial activity and is expressed in keratinocytes and the epithelia of many organs.
 D9690
Defensin HNP-1 human ≥80% (HPLC) This is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils. Defensins are a family of 3-4 kDa (29-34 amino acids) peptides found in the granules of mammalian phagocytes. The members of this family are variably arginine-rich and share six conserved cysteine residues that participate in intramolecular disulfide bonds.
 D2043
Defensin HNP-2 human ≥95% (HPLC) This is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils. Defensins are a family of 3-4 kDa (29-34 amino acids) peptides found in the granules of mammalian phagocytes. The members of this famuly are variably arginine-rich and all share 6 conserved cysteine residues that participate in intramolecular disulfide bonds.
 D6790
Demeclocycline hydrochloride powder An antibiotic related to tetracycline and produced by streptomyces aureofaciens. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
 D6140
Dexamethasone ≥98% (HPLC), powder Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
 D1756
Dexamethasone powder, ≥97%, cell culture tested Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
 D4902
Dexamethasone powder, γ-irradiated, cell culture tested Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
 D8893
Dexamethasone Sigma Reference Standard Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.
 D6645
Dexamethasone 21-acetate ≥99% An anti-inflammatory glucocorticoid.
 D1881
Dexamethasone 21-phosphate disodium salt ≥98% An anti-inflammatory glucocorticoid, a pro-drug that is converted to dexamethasone in vivo; stimulates glutamine uptake in the cerebral cortex
 D1159
Dexamethasone-Water Soluble cell culture tested D2915
cis-Diammineplatinum(II) dichloride crystalline Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.
Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.
 P4394
S-(1,2-Dicarboxyethyl)glutathione ≥97% (HPLC) Natural anti-inflammatory peptide that inhibits histamine release in vitro.
 D2804
Erythromycin potency: ≥850 μg per mg Mode of Action: Inhibits elongation at transpeptidation step.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
 E6376
Fenspiride hydrochloride >99% (TLC), powder Bronchodilator with anti-inflammatory properties. Inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. It also may be an antagonist at α adrenergic and H1 histamine receptors.
 F6145
Fluconazole ≥98% (HPLC), solid Fluconazole is an antifungal agent. It is highly selective inhibitor of fungal cytochrome P-450 sterol C-14 α-demethyllation. Fluconazole is a potent inhibitor of CYP2C9. Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene.
 F8929
Flunisolide ≥97% F5021
N-Formyl-Met-Leu-Phe ≥97% (HPLC) Potent inducer of leucocyte chemotaxis and macrophage activator. Receptors that bind formylpeptides are found on phagocytic neutrophils and have recently been identified on cells of the intestinal mucosa.
 F3506
Furaltadone F9130
Furaltadone hydrochloride F9255
Furaltadone tartrate salt F9380
Gliotoxin from Gliocladium fimbriatum An antiphagocytic and immunomodulating agent that acts by blocking membrane thiol groups.
 G9893
GR 144053 trihydrochloride hydrate ≥98% (HPLC), solid Non-peptide glycoprotein (GP) IIb/IIIa fibrinogen receptor antagonist.
 G6418
Hexa-N-acetylchitohexaose ≥95% H1396
Hymenistatin I >99% (HPLC) Exerts an immunosuppressive effect on humoral and cellular immune responses similar to cyclosporin A.
 H8409
IDR-1 ≥95% (HPLC) New IDR-1 is an anti-infective peptide that acts on the host to stimulate the innate immune response. IDR-1 is believed to act by enhancing monocyte chemokines, while reducing pro-inflammatory cytokines (decreased TNF and IL-6 and increased IL-10).
 I6409
Imipenem monohydrate ≥98% (HPLC), solid New Imipenem monohydrate is a broad spectrum B-lactam antibiotic. It is a member of the carbapenem class of “magic bullet” antibiotics for severe infections.
 I0160
trans-4-Iodo-4'-boranyl-chalcone ≥97% (HPLC), solid MDM2 (mouse double minute 2) inhibitor; immunomodulator.
 I1159
Ketoconazole ≥98% (TLC) Antifungal agent
 K1003
Lactoferricin B, fragment 4-14 trifluoroacetate salt ≥95% (HPLC) Antibiotic peptide in colostrum and milk that protects from bacterial infection at mucosal surfaces.
 L1290
Leflunomide Immunosuppressive; inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is believed to inhibit dihydroorotate dehydrogenase (in the de novo pyrimidine synthesis pathway) as well as several protein tyrosine kinases.
 L5025
Linomide ≥98% (HPLC), solid Immunomodulator; anti-angiogenic. Upregulates IL-10 and decreases CXC chemokine production. Upregulates mRNA of IL-23, IL-12p35, and IFNγ. Also, antagonizes hepatic effects of TNFα by blocking recruitment of inflammatory cell infiltration.
 L1793
Lipopolysaccharides from Escherichia coli 0111:B4 cell culture tested, γ-irradiated L4391
Lipopolysaccharides from Escherichia coli 0127:B8 cell culture tested, γ-irradiated L4516
Lipopolysaccharides from Escherichia coli 026:B6 cell culture tested, γ-irradiated L2654
Lipopolysaccharides from Escherichia coli 055:B5 cell culture tested, γ-irradiated L6529
Lipopolysaccharides from Salmonella enterica serotype typhimurium cell culture tested, γ-irradiated L6143
Magainin I ≥97% (HPLC) Antibiotic peptide. Thought to preferentially bind to anionic phospholipids abundant in bacterial membranes with the formation of dynamic peptide-lipid supramolecular pore and cell permeabilization, magainins are positively charged and amphiphatic. Binding to artificial neutral membranes has also been demonstrated.
 M7152
Magainin II ≥97% (HPLC) Antibiotic peptide. Magainins are positively charged and amphiphatic. Thought to preferentially bind to anionic phospholipids abundant in bacterial membranes with the formation of dynamic peptide-lipid supramolecular pore and cell permeabilization. Binding to artificial neutral membranes has also been demonstrated.
 M7402
[Ala8,13,18]-Magainin II amide ≥97% (HPLC) Magainin analog with greater anti-microbial activity.
 M8155
Mycophenolic acid ≥98% Immunosuppressive agent. Suppresses cytokine-induced nitric oxide production.
Mode of Action: Blocks inosine monophosphate dehydrogenase in the guanosine monophosphate pathway.
 M5255
Mycophenolic acid powder, ≥98%, cell culture tested Immunosuppressive agent. Suppresses cytokine-induced nitric oxide production.
Mode of Action: Blocks inosine monophosphate dehydrogenase in the guanosine monophosphate pathway.
 M3536
Ofloxacin O8757
Oxaprozin solid O9637
Oxatomide ≥99% Useful anti-allergy compound. Suppresses PAF-induced bronchoconstriction in guinea pig. Inhibits the release and action of leukotrienes and other mediators.
 O9387
PD 404,182 ≥98% (HPLC) Potential antibiotic of gram negative bacteria. KDO-8-P synthase inhibitor.
 P2742
Pirfenidone ≥97% (HPLC), solid Inhibits collagen production and fibroblast proliferation.
 P2116
Rapamycin from Streptomyces hygroscopicus ≥95% (HPLC), powder Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.
 R0395
Repertaxin L-lysine salt ≥97% (HPLC), lyophilized powder Repertaxin is a noncompetitive allosteric inhibitor of the inflammatory CXCL8 chemokine receptors CXCR1 and CXCR2.
 R5154
Rhein Constituent that is enriched in rhubarb with anti-inflammatory, anti-osteoarthritic, and anti-cancer activity. It reduces IL-1β production and secretion, caspase-3 activity, inducible nitric oxide synthase activity, and phosphorylation of c-Jun and c-Jun NH2-terminal kinase (JNK).
 R7269
Rifabutin >98% (HPLC), solid New Rifabutin is an antibiotic; antitumor. Rifabutin interferes with HSP-90 molecular chaperone, enhances ubiquitination and protein degradation, and inactivates bacterial RNA polymerase.
 R3530
Ser-Leu-Ile-Gly-Arg-Leu-amide trifluoroacetate salt ≥95% (HPLC)