Order Center
 
Product Catalog →  Cell Biology →  Cell Signaling and Neuroscience →  Peptides and Proteins →  Peptides →  Neuropeptides →  Angiotensins
 Print Preview

Angiotensins

Description
Biochem/physiol Actions
Product #
Abz-LFK(Dnp)-OH trifluoroacetate salt ≥98% (HPLC), powder Abz-LFK(Dnp)-OH is an Angiotensin Converting Enzyme (ACE) fluorescent peptide substrate specific for the C domain for real time fluorescent assay (ACE, Peptidyl Dipeptidase, Kininase II, E.C. 3.4.15.1).
 A5855
Angiotensin Fragment 1-7 acetate hydrate ≥90% (HPLC), powder Angiotensin I metabolite that is an AT2 receptor agonist.
 A9202
Angiotensin I human acetate hydrate ≥90% (HPLC) Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.
 A9650
Angiotensin I human acetate hydrate BioChemika, synthetic, ≥97.0% (HPCE) Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.
 10382
[Asn1, Val5]-Angiotensin II ≥97% (HPLC) Angiotensin agonist that has been isolated from kallikrein or renal-extract treated plasma and is involved in the regulation of blood pressure, water consumption, and hydromineral balance in fish.
 A6402
[Sar1, Thr8]-Angiotensin II acetate hydrate ≥97% (HPLC) Potent, long-acting antagonist of angiotensin II.
 A9900
[Sar1, Val5, Ala8]-Angiotensin II acetate hydrate ≥97% (HPLC), powder Competitive angiotensin II antagonist; inhibits pressor effects of angiotensin II in rats and lowers blood pressure in humans.
 A2275
[Val5]-Angiotensin II acetate hydrate ≥95% (HPLC), powder Angiotensin II analog that is an agonist at1 angiotensin receptors.
 A2900
Angiotensin II human ~95% (HPLC), powder Angiotensin (Ang) II is important in regulating cardiovascular hemodynamics and cardiovascular structure. Most of the known effects of Ang II in adult tissues are attributable to the angiotensin II type I (AT1) receptor. The AT1 and AT2 receptors have differential pharmacological and biochemical properties and appear to exert opposite effects in terms of cardiovascular hemodynamics and cell growth. In addition, the renin-angiotensin and nitric oxide-generating systems appear to interract in the regulation of cardiovascular function. Ang II stimulates angiogenesis and increases microvessel density. In nature, angiotensin II is produced by the action of angiotensin converting enzyme on angiotensinogen; the C-terminal-His-Leu is cleaved.
 A9525
Angiotensin II human acetate BioChemika, synthetic, ≥96.0% (HPCE) 10383
Angiotensin III BioChemika, ≥98.0% (HPCE) 10385
[des-Arg1]-Angiotensin III ≥95% (HPLC), lyophilized powder A1599
[Val4]-Angiotensin III acetate hydrate ≥97% (HPLC) A6277
Angiotensin IV trifluoroacetate salt ≥95% (HPLC), powder AT4 angiotensin receptor agonist. The AT4 receptor appears to be important in synaptic plasticity and thus in learning and memory.
A0230
Apelin-13 trifluoroacetate salt ≥95% Synthetic endogenous peptide agonist for the human APJ receptor, a putative receptor protein related to the angiotensin receptor (AT1). This peptide exerted an acidification-rate-promoting activity in CHO cells expressing the APJ receptor with a median effective concentration (EC50) value of 0.37 nM. Blocks HIV-1 and HIV-2 entry into cells expressing the APJ receptor.
 A6469
CGP-42112A ≥95%, synthetic, solid Potent AT2 angiotensin II receptor agonist.
 C160
L-162,313 ≥98%, solid Non-peptide AT1 receptor agonist.
 L1415
Moexipril hydrochloride solid, 97.9% (HPLC) Moexipril is an ACE-Inhibitor; Antihypertensive; Unlike other ACE inhibitors, prolongs QT interval leading to torsades de pointes and cardiad arrhythmia;
 M0821
S-(+)-PD 123177 trifluoroacetate salt hydrate ≥98% (HPLC), solid S-(+)-PD 123177 is selective AT2 angiotensin receptor antagonist. The angiotensin AT2 receptor is an atypical seven transmembrane domain receptor that is coupled to activation of tyrosine phosphatase and inhibition of MAP kinase, and does not undergo agonist-induced internalization. An investigation of the occurrence and nature of AT2 receptor phosphorylation revealed that phorbol ester-induced activation of protein kinase C (PKC) in HA-AT2 receptor-expressing COS-7 cells caused rapid and specific phosphorylation of a single residue (Ser354) located in the cytoplasmic tail of the receptor. Agonist activation of AT2 receptors by angiotensin II (Ang II) also caused rapid PKC-dependent phosphorylation of Ser354 that was prevented by the AT2 antagonist, S-(+)-PD 123177, and by inhibitors of PKC. In cells coexpressing AT1 and AT2 receptors, Ang II-induced phosphorylation of the AT2 receptor was reduced by S-(+)-PD 123177 and abolished by treatment with both antagonists or with PKC inhibitors. These findings indicate that the AT2 receptor is rapidly phosphorylated via PKC during homologous activation by Ang II, and also undergoes heterologous PKC-dependent phosphorylation during activation of the AT1 receptor.
 P5749
PD 123,319 di(trifluoroacetate) salt hydrate powder, ≥98% (HPLC) Potent and selective non-peptide AT2 angiotensin II receptor antagonist.
 P186

 Site Use Terms | Terms and Conditions of Sale | Privacy |
Copyrights © 2008 Sigma-Aldrich Co. All Rights Reserved. Reproduction of any materials from the site is strictly forbidden without permission. Sigma-Aldrich brand products are sold exclusively through Sigma-Aldrich, Inc.