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Agonists

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(−)-MDO-NPA hydrochloride 81264-57-5 M121
(−)-Quinpirole hydrochloride ≥98% (HPLC), solid The putative D2 dopamine receptor agonist quinpirole (LY 171,555) is the most widely used D2 agonist in in vivo and in vitro studies Active enantiomer of (±)-quinpirole. Quinpirole is a dopamine agonist with high affinity for the D2 and D3 dopamine receptor subtypes. Specific [3H]quinpirole binding in rat brain was saturable, and dependent on temperature, membrane concentration, sodium concentration and guanine nucleotides. Saturation analysis revealed high affinity binding characteristics (KD = 2.3 +/- 0.3 nM) which were confirmed by association-dissociation kinetics. The regional distribution of [3H]quinpirole binding sites roughly paralleled the distribution of [3H]spiperone binding sites, with greatest densities present in the striatum, nucleus accumbens and olfactory tubercles. A variety of drugs, most notably monoamine oxidase inhibitors (MAOls), inhibit the binding of [3H]quinpirole, but not [3H]spiperone or [3H](-)N-n-Propylnorapomorphine, in rat striatal membranes by a mechanism that does not appear to involve the enzymatic activity of MAO. Clinically antidepressant MAOIs exhibited selectivity between sites labeled by [3H]quinpirole and [3H]spiperone as did a number of structurally related propargylamines and N-acylethylenediamine derivatives and other drugs such as debrisoquin and phenylbiguanide. The MAOIs clorgyline and Ro 41-1049 were the most potent. MAOIs interact with a novel binding site that is labeled by [3H]quinpirole or that modulates [3H]quinpirole binding. This site may be associated with D2-like dopamine receptors.
 85798-08-9 Q102
(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide solid Dopamine receptor agonist.
 13575-86-5 D002
(±)-6-Chloro-PB hydrobromide ≥98% (HPLC), solid (+/-)-6-CHLORO-PB HBR is a full D1 dopamine receptor agonist.
 71636-61-8 S143
(±)-7-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide A selective D3 dopamine receptor agonist (Kd <1nM); has much weaker affinity for other dopamine receptor subtypes.
 159795-63-8 H8653
(±)-PD 128,907 hydrochloride solid, ≥98% (HPLC) Selective D3 dopamine receptor agonist.
 112960-16-4 P216
(±)-PPHT hydrochloride ≥98% (HPLC), solid A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of (±)-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 ((±)-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.
Potent D2 dopamine receptor agonist.
 71787-90-1 P105
(±)-Quinpirole dihydrochloride solid D2-like dopamine receptor agonist that possesses some activity at D3 sites.
 73625-62-4 Q111
(±)-SKF-38393 hydrochloride crystalline, ≥98% (HPLC) D1 Dopamine receptor agonist.
 62717-42-4 D047
(+)-PD 128,907 hydrochloride >97%, solid Selective D3 dopamine receptor agonist.
 300576-59-4 P183
(R)-(+)-SKF-38393 hydrochloride ≥98% (HPLC), solid D1 dopamine receptor agonist; active enantiomer of (±)-SKF-38393.
 81702-42-3 S101
(R)-SKF-82957 hydrobromide solid Selective D1 dopamine receptor agonist.
 288262-87-3 S178
(S)-(−)-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride ≥98% (HPLC), solid Dopamine autoreceptor agonist; postsynaptic dopamine receptor antagonist.
 88768-67-6 P103
2-Bromo-α-ergocryptine methanesulfonate salt solid Agonist at D2 and D3 dopamine receptors; inhibits prolactin secretion.
 22260-51-1 B2134
A-68930 hydrochloride ≥98% (HPLC), solid Selective D1 dopamine receptor agonist
 130465-39-3 A8852
A-77636 hydrochloride hydrate ≥98% (HPLC), solid Potent, orally active D1 dopamine receptor agonist.
 145307-34-2 (anhydrous) A255
BP897 >98% (HPLC), solid Partially selective D3 dopamine receptor agonist.
 314776-92-6 B9308
Chloro-APB hydrobromide solid Full D1 dopamine receptor agonist.
 80751-65-1 C130
Deoxyepinephrine hydrochloride ≥95%, solid Dopamine receptor agonist, α-adrenoceptor agonist.
 62-32-8 D5886
Dopamine hydrochloride Neurotransmitter.
 62-31-7 H8502
FAUC 73 liquid Selective, potent and nonaromatic D3 dopamine receptor agonist
 F1041
Fenoldopam monohydrobromide ≥98% Fenoldopam is a selective dopamine agonist that is being considered for the parenteral treatment of systemic hypertension. In both an oral and parenteral form, fenoldopam causes peripheral vasodilation by stimulating dopamine-1 adrenergic receptors. Intravenous fenoldopam may provide advantages over sodium nitroprusside because it can induce both a diuresis and natriuresis, is not light sensitive, and is not associated with cyanide toxicity. There is no evidence for rebound hypertension after discontinuation of fenoldopam infusion.
 67287-54-1 F6800
N-Allyl-(±)-SKF-38393 hydrobromide solid, ≥98% (HPLC) Centrally active D1 dopamine receptor agonist.
 300561-58-4 S168
N-[2-(4-(4-Chlorophenyl)piperazin-1-yl)ethyl]-3-methoxybenzamide solid Potent, selective D4 dopamine receptor ligand.
 C7230
PD 168,077 maleate salt powder Selective D4 dopamine receptor agonist.
 190383-31-4 P233
Pergolide mesylate salt ≥98%, solid Dopaminergic agonist; suppresses pituitary secretion of prolactin; anti-Parkinsonian agent.
 66104-23-2 P8828
Piribedil maleate salt A direct dopamine agonist; may be selective for the D3 subtype; no significant affinity for D1 receptors.
 P9233
Quinelorane dihydrochloride crystalline D2 dopamine receptor agonist; 2-aminopyridine analog of quinpirole.
 97548-97-5 Q110
R(−)-2,10,11-Trihydroxy-N-propyl-noraporphine hydrobromide hydrate solid Potent, selective D2 dopamine receptor agonist.
 79640-85-0 (anhydrous) D030
R(−)-2,10,11-Trihydroxyaporphine hydrobromide >97%, small crystals Dopamine receptor agonist.
 77630-01-4 D029
R(−)-Propylnorapomorphine hydrochloride solid Highly potent and selective D2 dopamine receptor agonist.
 18426-20-5 D027
R(−)-Apocodeine hydrochloride solid Dopamine receptor agonist; apomorphine metabolite.
 641-36-1 D003
R(–)-Norapomorphine hydrobromide solid Dopamine receptor agonist.
 478-76-2 D040
R(+)-3-(3-Hydroxyphenyl)-N-propylpiperidine hydrochloride solid D2 dopamine receptor agonist. Also functions as σ1 receptor antagonist with essentially no affinity for the phencylidine site on the NMDA receptor.
 89874-80-6 P102
R(+)-6-Bromo-APB hydrobromide solid D1 Dopamine receptor agonist; more potent enantiomer.
 B135
R(+)-7-Hydroxy-DPAT hydrobromide >98%, solid Selective D3 dopamine receptor agonist; active enantiomer of (±)-7-hydroxy-DPAT
 82730-72-1 H168
R(+)-SKF-81297 hydrobromide ≥98% (HPLC), solid R(+)-SKF-81297 hydrobromide is a selective D1 dopamine receptor agonist.
 253446-15-0 S179
R-(−)-Apomorphine hydrochloride hemihydrate calcined, ≥98.5% Nonselective dopamine agonist; causes nausea and emesis.
 41372-20-7 A4393
Ropinirole hydrochloride solid, ≥98% (HPLC) An agonist at the D2 and D3 dopamine receptor subtypes, binding with higher affinity to D3 than to D2 or D4. It has negligible effect on D1-receptors. It has medium in vitro affinity to opioid receptors. Ropinirole is said to have virtually no affinity to 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, alpha1-, alpha2-, and beta-adrenoreceptors. Used as antiparkinsonian drug.
Selective D2 dopamine receptor agonist, antiparkinsonian
 91374-20-8 R2530
S(+)-Terguride solid Ergot derivative; dehydrogenated analog of lisuride; D2 dopamine receptor partial agonist.
 37686-84-3 T165
S-(−)-SKF-38393 hydrochloride solid D1 dopamine receptor agonist; less active enantiomer of (±)-SKF-38393.
 81702-43-4 S102
SKF-75670 hydrobromide >98% (HPLC), solid Atypical D1 dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo.
 S2941
SKF-83959 hydrobromide >98% (HPLC), solid D1 dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo.