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Tachykinins

Ascending pain pathways. IL: intralaminar nucleus of the thalamus, VP: ventroposterior nucleus of the thalamus.

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Description	Biochem/physiol Actions	Product #
N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester ≥99% (TLC), powder	Competitive substance P receptor antagonist. It is approximately 1000-fold more potent at cloned human NK-1 receptors than at cloned human NK-2 and NK-3 receptors; and approximately 200-fold more potent at human NK-1 receptors than at rat NK-1 receptors. The IC₅₀ for the human NK-1 receptor expressed in CHO cells is approximately 2 nM.	A5330
Entero-hylambatin >97% (HPLC), powder		H4534
GR 64349 >96%	Potent and selective agonist at the NK-2 tachykinin receptor.	G113
GR 73632 >97%	Potent and specific agonist at the NK-1 tachykinin receptor.	G114
GR 82334 >97%	Potent and specific reversible antagonist at the NK-1 tachykinin receptor.	G115
GR 94800 >96%, powder	Selective NK-2 tachykinin receptor antagonist.	G130
Hemokinin 1 human ≥98% (HPLC), solid	NK₁ tachykinin receptor agonist.	H1664
Hylambatin >96% (HPLC)	Tachykinin that increases plasma glucose and plasma insulin.	H0409
L-659,877 >95%, powder	Potent and selective NK-2 tachykinin receptor antagonist.	L117
L-703,606 oxalate salt hydrate solid	Potent and selective non-peptide NK-1 tachykinin receptor antagonist.	L119
L-733,060 hydrochloride solid, ≥98% (HPLC)	Non-peptide NK₁ tachykinin receptor antagonist; selective for guinea pig/human versus rat/mouse.	L137
L-733,061 hydrochloride solid	Weak NK-1 tachykinin receptor antagonist; less active enantiomer of L-733,060 hydrochloride.	L138
MEN-10,376 ≥95% (HPLC), solid	Potent and selective NK-2 tachykinin receptor antagonist.	M157
Neurokinin A ≥97% (HPLC)	Endogenous tachykinin agonist with preference for the NK-2 receptor, more potent bronchoconstrictor than Substance P.	N4267
Neurokinin B ≥95% (HPLC)	Endogenous tachykinin agonist with preference for the NK-3 receptor. Potent bronchoconstrictor; may have neuromodulatory role in brain.	N4143
[β-Ala⁸]-Neurokinin A Fragment 4-10 ≥97% (HPLC), powder	Potent and selective NK-2 tachykinin receptor agonist.	N147
[Ala⁵, β-Ala⁸]-α-Neurokinin Fragment 4-10 ≥97% (HPLC)	NK-2 tachykinin receptor agonist.	N6144
SB 218795 >98% (HPLC)	Non-peptide NK₃ tachykinin receptor antagonist.	S8817
SB 222200 ≥98% (HPLC), solid	Non-peptide NK₃ tachykinin receptor antagonist.	S5192
Substance P acetate salt hydrate ≥95% (HPLC), powder	NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.	S6883
Substance P acetate salt hydrate BioChemika, PeptiSelect, ≥98.0% (HPCE)	NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.	85965
[D-Arg¹, D-Phe⁵, D-Trp^7,9, Leu¹¹]-Substance P ≥97% (HPLC)	NK-1 tachykinin receptor antagonist	S3144
[D-Arg¹, D-Trp^7,9, Leu¹¹]-Substance P acetate salt ≥97% (HPLC)	Potent NK-1 tachykinin receptor antagonist.	S0274
[Sar⁹]-Substance P ≥97% (HPLC)	NK-1 receptor agonist.	S6636
[Sar⁹, Met(O₂)¹¹]-Substance P ≥97% (HPLC)	Highly selective NK-1 receptor agonist.	S3672
Acetyl-[Arg⁶, Sar⁹, Met(O₂)¹¹]-Substance P Fragment 6-11 ≥95%	Selective NK-1 receptor agonist.	S2275
Succinyl-[Asp⁶, N-Me-Phe⁸]-Substance P Fragment 6-11 ≥97% (HPLC)	Selective NK-3 tachykinin receptor agonist.	S6772
WIN 51708 hydrate solid	WIN 51708 hydrate is a non-peptide NK₁ tachykinin receptor antagonist.	W103
WIN 62,577 solid	Non-peptide NK₁ tachykinin receptor antagonist.	W104

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