Product Catalog → Cell Biology → Cell Signaling and Neuroscience → G Proteins and Cyclic Nucleotides → G Protein Function → Post-translational Modification

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Post-translational Modification

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Description	Biochem/physiol Actions	Product #
B581 >95% (HPLC), solid	Stable and membrane permeable. Inhibitor of farnesyltransferase.	B2559
Cys-Val-2-Nal-Met ≥90% (HPLC)	p21^ras farnesyltransferase inhibitor.	C4433
Dynasore monohydrate ≥98% (HPLC), solid	Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.	D7693
Exo 1 ≥98% (HPLC), solid	Reversible inhibitor of exocytosis; Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator.	E8280
Farnesyl monophosphate ammonium salt solution ≥95% (TLC), methanol:ammonia solution		F1803
Farnesyl pyrophosphate ammonium salt methanol:ammonia solution, ≥95% (TLC)	Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras.	F6892
Farnesyl triphosphate ammonium salt solution ≥95% (TLC), methanol:ammonia solution		F1928
FTI-276 ≥95% (HPLC), solid	Highly potent RasCAAX peptidomimetic, antagonizes both H and K-Ras oncogenic signaling. Inhibitor of farnesyltransferase (Ftase)in vitro with IC₅₀500 pM. Potential new anti-cancer agent.	F9553
FTI-277 trifluoroacetate salt >95.0% (HPLC), amorphous semi-solid	Highly potent (pM/nM) Ras CAAX peptidomimetic which antagonizes both H and K-Ras oncogenic signaling. Inhibitor of farnesyltransferase (Ftase) IC₅₀= 50 nM	F9803
Geranylgeranyl monophosphate ammonium salt solution ≥95% (TLC), methanol:ammonia solution		G2543
Geranylgeranyl pyrophosphate ammonium salt solution, ≥95% (TLC), ~1 mg/mL in methanol: NH₄OH (7:3)	Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular weight G proteins, including Ras. Intermediate in terpene biosynthesis.	G6025
Geranylgeranyl triphosphate ammonium salt solution ≥95% (TLC), methanol:ammonia solution		G2668
Geranyl monophosphate ammonium salt solution ≥95% (TLC), methanol:ammonia solution		G2293
Geranyl triphosphate ammonium salt solution ≥95%, methanol:ammonia solution		G2418
α-Hydroxyfarnesylphosphonic acid 2 mg/mL in ethanol	Inhibitor of farnesyltransferase; much weaker activity against geranylgeranyl transferase.	H9279
Isopentenyl monophosphate ammonium salt solution ≥95% (TLC)	Isoprenoid building block.	I1157
Isopentenyl triphosphate ammonium salt solution ≥95% (TLC)	Isoprenoid building block.	I1282
Manumycin A from Streptomyces parvulus	Potent inhibitor of Ras farnesyltransferase.	M6418
MRS 2578 ≥95% (HPLC), solid	Potent and irreversible antagonist of P2Y₆nucleotide receptor.	M0319
Myristoyl chloride ≥99%	Fatty acid containing 14 carbons. Covalent attachment of myristate is a common occurrence on a wide variety of viral and cellular proteins and plays a role in promoting membrane binding.	M8255
Myristoyl coenzyme A lithium salt min. 80%		M4414
Palmitoyl chloride 98%		P78
Palmitoyl coenzyme A lithium salt ≥90%	Long chain fatty acid (C16) covalently linked to Coenzyme A. Covalent attachment of palmitate is a common occurrence on a wide variety of viral and cellular proteins and plays a role in promoting membrane binding. Palmitoylation may also be a general mechanism for prolonging or potentiating G-protein signaling.	P9716
(S)-(−)-Perillic acid	Interferes with activity of p21^ras and other small G proteins by inhibiting post-translational cysteine isoprenylation.	P7083

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