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Enzymes

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Description	Biochem/physiol Actions	Product #
Acyl-coenzyme A Synthetase from Pseudomonas sp. ≥2 units/mg protein		A3352
Rac-1 protein human ≥85%, recombinant, expressed in Escherichia coli, buffered aqueous glycerol solution	GTP-binding protein that is a member of the ras gene superfamily and Rho family of proteins. Rac-1 protein is involved in the regulation of a variety of signaling pathways that control cell growth and differentiation. Rac-1 is suitable as a substrate for geranylgeranyltransferase.	R3012
Ral B human recombinant, expressed in Escherichia coli, buffered aqueous glycerol solution	Ral B (21 kDa, native), a member of the Ras-like GTP binding protein family, is a crucial link in intracellular signaling cascades.	R2027
Rap1A human buffered aqueous glycerol solution, recombinant, expressed in Escherichia coli, GST-tagged	Rap1A, a small Ras-like GTP-binding protein (21 kDa, native), is a potential modulator of the Ras/Raf/MAP kinase intracellular signaling cascade.	R2152
Ras human Wild type, ~95% (SDS-PAGE), recombinant, expressed in Escherichia coli, buffered aqueous glycerol solution		R9894
W56 96% (HPLC), lyophilized powder	W56 (concentrations >200 µM) selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1, and Tiam1, which activate subsequent G proteins. The peptide comprises residues 45-60 of the β3 region of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. W56 targets the Trp56 site of Rac1. It has implications in research of actin cytoskeleton reorganization, transcriptional activation of genes, stimulation of DNA synthesis, endocytic and exocytic membrane trafficking, regulation of translation, and pathologies such as cancer.	W4392

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