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Neurotransmitter Receptors

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Description	Biochem/physiol Actions	Product #
Acetylcholine Receptor α1, Fragment 129-145 Amino acids 129-145 of human, bovine, rat, and mouse sequence, ≥93% (HPLC)		A2352
Adenosine Transporter Receptor human membrane suspension	Membranes suspended in 50 mM Tris-HCl containing10% sucrose, pH 7.4. Actual concentration and specific binding capacity are provided with each lot.	A8352
α_2A-Adrenergic Receptor human recombinant, expressed in Sf9 cells, membrane suspension		A213
β₁-Adrenergic Receptor preparation human	Membranes suspended in 50 mM Tris-HCl containing 12 mM MgCl₂ and 2 mM EDTA, pH 7.4. Actual concentration and specific binding capacity are provided with each lot.	A6728
β₂-Adrenergic Receptor preparation human frozen liquid		A0229
AZ11645373 ≥98% (HPLC), solid	AZ11645373 is a selective and potent human P2X₇ purinoceptor antagonist. K_B values range from 5-20 nM for human P2X₇receptor inhibition. It is 500-fold less effective ats an inhibitor of rat P2X7 receptor responses.	A7231
CHPG ≥98% (HPLC), solid	CHPG is a selective, potent mGluR5 agonist. CHO cells expressing mGluR5 (but not those expressing mGluR1) are activated by CHPG. In vivo, CHPG stimulates thalamic neurons and is antagonized by MPEP (selective mGluR5 antagonist); CHPG potentiates NMDA and AMPA responses in spinal cord and produces oscillations in intracellular calcium in dorsal root ganglion cells.	C7743
D₃ Dopamine Receptor from rat recombinant, expressed in Escherichia coli, membrane suspension		D181
D₃ Dopamine Receptor human recombinant, expressed in CCLI-3 cells, membrane suspension		D152
5-HT_1A Serotonin Receptor human recombinant, expressed in Sf9 cells, membrane suspension		S160
5-HT₇ Serotonin Receptor human recombinant, expressed in CHO cells, membrane suspension		S177
Mosapride citrate dihydrate	5-HT₄ receptor agonist and 5-HT₃receptor antagonist	M2946
NK₂ Tachykinin Receptor human recombinant, expressed in CHO cells, membrane suspension		T180
Ro 27-3225 trifluoroacetate salt ≥98% (reversed phase HPLC), solid	Ro 27-3225 is a selective melanocortin MC4 receptor agonist. EC50 = 1 nM. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. Ro 27-3225 may have a protective role against multiple organ failure following circulatory shock. Ro 27-3225 also reduces food intake in ob/ob mice.	R3905
Serotonin Transporter Receptor membrane suspension		S1943
Talsaclidine ≥98% (HPLC), oil	Talsaclidine is a M₁ selective muscarinic receptor agonist. Concentration-dependently, talsaclidine increases the release of APPs and dose-dependently. Talsaclidine decreases Aβ formation and decreases cerebrospinal fluid Aβ in AD patients.	T2452
Telmisartan ≥98% (HPLC), solid	Telmisartan is a non-peptide AT₁ angiotensin receptor antagonist.	T8949

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