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Toxins and Venoms
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Scorpion
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Description
Biochem/physiol Actions
Product #
Charybdotoxin ≥90% (HPLC)
High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel blocker.
Potent and selective inhibitor of the Ca
2+
-activated K
+
channel present in GH
3
anterior pituitary cells and primary bovine aortic smooth muscle cells.
C7802
Charybdotoxin >98%, recombinant, expressed in
Escherichia coli
, lyophilized powder
High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel blocker.
C5856
Iberiotoxin
Selective and reversible inhibitor of high-conductance calcium-activated potassium channel.
I2141
Iberiotoxin >99% (HPLC), recombinant, expressed in
Escherichia coli
Selective and reversible inhibitor of high-conductance calcium-activated potassium channel.
I5904
Imperatoxin A >88%, lyophilized powder
Selective skeletal-type ryanodine sensitive intracellular Ca
2+
channel activator found in the scorpion
Pandinus
I148
Margatoxin >99%, recombinant, expressed in
Escherichia coli
Voltage-gated (Kv1.3) potassium channel blocker.
M8437
Margatoxin ≥90% (HPLC)
Specific K(V)1.3 channel voltage-dependent K
+
channel blocker
M8278
Pandinotoxin-Kα >99%, powder
High affinity, selective A-type (rapidly inactivating) voltage-gated K
+
channel blocker.
P222
Scorpion venom from
Leiurus quinquestriatus hebraeus
Source of chlorotoxin, an intracellular blocker of low-conductance Cl
-
channels; and charybdotoxin, a blocker of voltage-sensitive Ca
2+
-activated K
+
channels.
V1755
Scorpion venom from
Centruroides sculpturatus
V9752
Scorpion venom from
Tityus serrulatus
V1752
Scorpion venom from
Leiurus quinquestriatus
(north Africa)
V5251
Scorpion venom from
Scorpio maurus palmatus
V5376
Tityustoxin-Kα from
Tityus serrulatus
(Brazilian scorpion) venom lyophilized powder
Potent and selective voltage-gated non-inactivating (delayed-rectifier) K
+
channel blocker.
T154
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