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Myeloma is a cancer of the antibody-producing cells. It occurs spontaneously in humans and mice, and can be induced by injecting some substances such as mineral oil, pristane, or viruses into the peritoneum. Myeloma cells continue to secrete immunoglobulins in a normal fashion but exhibit uncontrolled growth. Plasmacytomas have been cloned from myelomas, yielding cell lines that produce a completely homogeneous population of myeloma immunoglobulin bearing a single heavy chain isotype and a single light chain type.
Common myeloma abbreviations: MO: Mineral Oil (as in MOPC) HO: 7n Hexyloctadecane (as in HOPC) TE: Tetrametylpentadecane (pristane) (as in TEPC) Y: Yance AB: Abelson virus (as in ABPC) PC: Plasmacytoma |
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