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    Search term:"ligands"

    570 matches found for ligands

    Mild Palladium-Catalyzed Cyanation of (Hetero)aryl Halides and Triflates in Aqueous Media-

    The development of a novel Pd-catalyzed synthesis of (hetero)aromatic nitriles from the corresponding aryl chlorides and potassium hexacyanoferrate(II) is described. This novel protocol avoids the use of highly toxic alkali cyanides and proceeds in the presence of small amounts of palladium catalyst...

    BrettPhos Ligand Supported Palladium-Catalyzed C-O Bond Formation through an Electronic Pathway of Reductive Elimination: Fluoroalkoxylation of Activated Aryl Halides

    A Pd/N-heterocyclic carbene-based catalyst achieves the Sonogashira coupling of an array of functionalized, ?-hydrogen-containing alkyl bromides and iodides under mild conditions. By furnishing the first example of a nonphosphine-based palladium catalyst for cross-coupling unactivated alkyl electrop...

    A New Biarylphosphine Ligand for the Pd-Catalyzed Synthesis of Diaryl Ethers under Mild Conditions

    An efficient, general palladium catalyst for C-O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand�1. Heteroaryl halides, and for the first time, electron-rich aryl halides can be coupled with secondary alcohols. A diverse set o...

    KitAlysis™ C-N (Buchwald-Hartwig) High-Throughput Screening Kit

    Contents in each of the 4 individually sealed Mylar (foil bags): • 24 (12 x2) pre-weighed catalysts in glass vials loaded with stir bars, topped with cap mat. The screening sets come pre-loaded with 1 µmol of catalyst in each vial according to the following design. • Cesium Carbonate: ground and sie...

    Celltransmissions, Sept 2003, Volume 19, No. 3

    In this issue: Main Article: The Ubiquitin-Proteasome System: Death of Proteins is Required for Life of Cells Aaron Ciechanover New Products Click here to request Celltransmissions Click to download Celltransmissions Click for back issues of Celltransmissions Vol. 19, No. 3 Product Highlights: • Sta...

    C-O Cross-Coupling of Activated Aryl and Heteroaryl Halides with Aliphatic Alcohols-

    We report an unprecedented BrettPhos ligand supported Pd-catalyzed C-O bond-forming reaction of activated aryl halides with primary fluoroalkyl alcohols. We demonstrate that the Phosphine ligand (BrettPhos) possesses the property of altering the mechanistic pathway of reductive elimination from nucl...

    QuinoxP* Ligands

    Various optically active phosphine ligands incorporating a chiral center at the phosphorus display exceptional enantiosectivities in metal-catalyzed asymmetric synthesis.1 For instance, known classes of P-chiral phosphine ligands offer good to excellent enantiocontrol in Ru- and Rh-catalyzed hydroge...

    Landis Ligands in Chemical Synthesis

    Diazaphospholane Ligands for Catalytic Asymmetric Transformations Introduction The interest in asymmetric reactions has been growing for the past 40 years. To address the challenges of synthesizing chiral building blocks with high yields and high selectivities, researchers developed a broad range of...

    Custom Synthesis Services

    Sigma-Aldrich is the market leader in organic & inorganic chemicals, providing an innovative and comprehensive range of building blocks, reagents and advanced materials for chemical synthesis, medicinal chemistry and materials science. Area Of Expertise • Starting chemical building blocks • Pharmace...

    KIT ligand
    Synonyms FPH2, KL-1, Kitl, MGF, SCF, SF, SHEP7
    Species Human (4254) , Species Rat (60427) , Species Goat (100860807) , Species sheep (443371) , Species domestic guinea pig (100721734) , Species chicken (396028) , Species domestic cat (493937) , Species dog (403507) , Species Horse (100034127) , Species cow (281885)
    Summary: This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

    Product Citations and Publications

    • AQUA™ Peptides • PEPscreen®: Custom Peptide Libraries • SPOTs: Custom Peptide Arrays 1. Guenther, J.F., et al., Phosphorylation of soybean nodulin 26 on serine 262 enhances water permeability and is regulated developmentally and by osmotic signals. Plant Cell, 15(4), 981-991 (2003). Abstract 2. Br...

    Glutamate Receptors (G Protein Family)

    The existence of G protein-coupled glutamate receptors (also called "€œmetabotropic" glutamate or mGlu's), belonging to the seven transmembrane spanning superfamily of receptors, was shown definitively with the cloning of the first member in 1991. Since then, eight receptors of this class have been ...

    CBHA Ligands

    Aldrich ChemFiles 2010, 10.1, 5. Yamamoto and his group developed a new type of ligands based on the C2-symmetric chiral bishydroxamic acid (CBHA). These bidentate ligands have pendant "arms" that can be substituted with a variety of substituents allowing for a finetuning of the ligand potency. A va...

    Catalysis Guide

    • Highly Selective Palladium-Catalyzed Cross-Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides • Palladium-Catalyzed Amination of Unprotected Five-Membered Heterocyclic Bromides • Stereospecific Pd-Catalyzed Cross-Coupling Reactions of Secondary Alkylboron Nucleophiles and Aryl Chlori...

    Immunohistochemistry: Current Applications in Breast Cancer

    By: Mike Lacey, M.D. Recorded Webinar Immunohistochemistry (IHC) is used to characterize intracellular proteins or various cell surfaces in all tissues. Individual markers, or more often panels of various marker proteins, can be used to characterize various tumor subtypes, confirm tissue of origin, ...

    Non-Proprietary Phosphine Ligands

    Aldrich ChemFiles 2007, 7.5, 8. In the pharmaceutical industry, Pd-catalyzed processes have frequently been relied on for carrying out key bond formations. While there are many ligands available that efficiently mediate C–C and C–N bond formations, there is still a need for ligands that address the ...

    Affinity Chromatography

    Affinity chromatography is the preferred method of bioselective adsorption and subsequent recovery of a compound from an immobilized ligand. Each is designed for highly specific and efficient purification of proteins and related compounds. Sigma offers appropriately selective ligands on beaded and p...

    QuinoxP* Ligands

    Aldrich ChemFiles 2006, 6.10, 3. Various optically active phosphine ligands incorporating a chiral center at phosphorus display exceptional enantiosectivities in metal-catalyzed asymmetric synthesis.1 For instance, known classes of P-chiral phosphine ligands offer good to excellent enantiocontrol in...

    Astec Chiral Chromatography Bibliography by Subject

    Amino Acids, Peptides, Biomolecules Chemical, Environmental, Petrochemical Chiral LC-MS Food, Beverage, Natural Products Mechanistic Studies Pharmaceutical, Clinical Preparative, SFC, SMB Daniel W. Armstrong Publications Copyright restrictions do not permit us to provide copies of the articles liste...

    Detection, quantification and visualisation of protein interactions for hit profiling by high content screening

    Alongside established drug target classes, innovative approaches are addressing previously undruggable target classes such as protein–protein interactions. Protein interactions and their relocation within the cell have traditionally been studied using an over-expressed cell model or cell lysate meas...

    Sigma-Aldrich Chemistry Webinars

    Sigma-Aldrich Chemistry Webinars are Web-based seminars describing the latest, innovative chemical synthesis technologies and products from Sigma-Aldrich Chemistry. These seminars are convenient to navigate, interactive, and accessed directly via your desktop browser. 2016 From Milligrams to Kilogra...

    PHOX

    • • Download PDF • Of the thousands of chiral ligands used in asymmetric synthesis a relatively large number exhibit C2-symmetry. More recently, non-symmetrical modular P,N-ligands have been introduced independently by Pfaltz, Helmchen, and Williams and applied successfully in various metal-catalyze...

    Prestige Antibodies® in Breast Cancer Research

    • The Human Protein Atlas • Prestige Antibodies® Powered by Atlas Antibodies • Monoclonal Antibody Development • Clinical Markers (ESR1, HER2, Ki67, PGR) • Antibodies used in Breast Cancer Research • Antibodies Against Gene Products in MammaPrint, Oncotype, EndoPredict and uPA Tests • Antibodies Ide...

    Bioactive Small Molecules Catalog

    Complete the form below to request your copy of the NEW 2009–2010 Sigma® Bioactive Small Molecules catalog. Our comprehensive offering of small molecule modulators and approved drugs impacts most cellular processes and all major drug target classes. • Antiproliferatives • Enzyme inhibitors • Antibio...

    Mucin

    Mucins are a diverse family of densely glycosylated proteins. Mucin domains within the protein core are rich in threonine, serine and hydroxyproline enabling post-translational O-glycosylation. The highly glycosylated properties of mucins make them resistant to proteolysis and able to hold water, gi...

    Glutamate Receptors (Ion Channel Family)

    The ion channel family of glutamate receptors ("€œionotropic"€ glutamate receptors or iGluR) comprises three major subtypes based on pharmacology and protein structure. The N-methyl-D-aspartate (NMDA) subtype is a hetero-oligomer consisting of an NR1 subunit combined with one or more NR2 (A-D) subu...

    Non-Proprietary Phosphine Ligands

    • • Download PDF • In the pharmaceutical industry, Pd-catalyzed processes have frequently been relied on for carrying out key bond formations. While there are many ligands that efficiently mediate C–C and C–N bond formations, there is still a need for ligands that address the gaps in the current met...

    Palladium-Catalyzed Reaction of Aryl Iodides with ortho- Bromoanilines and Norbornene/Norbornadiene: Unexpected Formation of Dibenzoazepine Derivatives-

    The cross-coupling reaction of aryl bromides and iodides with aliphatic and aromatic thiols catalyzed by palladium complexes of the bisphosphine ligand CyPF-tBu (1) is reported. Reactions occur in excellent yields, broad scope, high tolerance of functional groups, and with turnover numbers that exce...

    Quinoline Ligands for Pd catalyzed C-H activation

    Pd catalyzed C-H activation is a powerful method for installing functional groups onto biologically relevant molecules. However, C(sp3)-H activation has proven quite challenging. Ligand selection is critical for these types of transformations because the ligands tune the metal catalyst’s reactivity ...

    Affinity Chromatography Literature

    Listed below are many references linked to PubMed, where you can find complete, relevant information. Share your discoveries with us and we will add the abstract to our list! We are interested in knowing how our affinity matrices have advanced your research. Sigma®'s enabling tools allow you to choo...

    BioFiles Volume 4, Number 5 | Growth Factors and Cytokines

    Growth Factors and Cytokines Table of Contents Download full issue (pdf 4MB) • Introduction • Growth Factors and Cytokines: Classification and Nomenclature • Epidermal Growth Factors (EFG) and NRG Family • Fibroblast Growth Factor Family (FGF) • Hematopoietic Cytokines • Growth Factors in Stem Cell ...