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    Search term:"transcription"

    268 matches found for transcription

    Nuclear Receptors (Non-Steroids)

    The receptors for several classes of non-steroidal compounds, including retinoids, thyroid hormones and vitamin D, also act as ligand-dependent transcription factors. In addition, a large number of receptors without known ligands have been discovered based on sequence homology, particularly in the D...

    Nuclear Receptors (PPARs)

    Peroxisome proliferator activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. PPARs play an important role in many cellular functions including lipid metabolis...

    Nuclear Receptors (Steroids)

    Intracellular receptors (IRs) are a class of ligand-dependent transcription factors that include receptors for both steroid and non-steroid hormones. Upon binding their cognate hormone, these receptors homo- or hetero-dimerize and regulate gene expression through multiple mechanisms. Ligand-bound IR...

    Cyclosporin A from Tolypocladium inflatum

    CAS RN 59865-13-3 Synonyms: Cyclosporine; Antibiotic S 7481F1; Ciclosporin; CsA Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes.2 It has been shown to inhibit the functioning of ...

    Neural Lineage Markers

    • • Download PDF • The ever evolving field of stem cell research has been a highly fascinating yet contested area of study. Stem cell research holds promise for many areas such as developmental biology, therapeutic and regenerative medicine, and drug discovery. Potton et al. described stem cells as ...

    Webinar: Cell Line Engineering and the Cell Design Studio

    Webinar Title: MilliporeSigma’s Cell Design Studio – Overcoming Challenges in Cell Line Engineering Date: Wednesday, September 13, 2017 Time: 9:00 AM CST Duration: 60 minutes Exclusive Seminar for GSK Gene editing has become a firmly established technology within the discovery sciences arena. With t...

    MISSION® esiRNA - Endoribonuclease-prepared siRNAs

    On this page: MISSION esiRNA Benefits esiRNA Targeting Long Non-coding RNA esiRNA Screening Video Tutorial esiRNA FAQ (Frequently Asked Questions) MISSION esiRNA Offering Ordering Information esiRNA Controls References esiRNA Technical Overview (921 Kb PDF) MISSION® esiRNA MISSION esiRNA provides RN...

    Guide to E. coli Markers in Molecular Biology

    In the descriptions below, the markers are described as the genes or gene products. dam Methylates A of GATC sites. The dam methyl pattern is used to distinguish old (methylated) from new (unmethylated) strands for damage-repair purposes (repair the unmethylated strand). Dam methylation is also used...

    Ribonuclease Inhibitor, human

    Ribonuclease Inhibitor from human placenta is a protein with a molecular mass of ~50 kDA by SDS-PAGE.1 Inhibition of ribonuclease activity occurs by the formation of a tight, non-covalent 1:1 complex having a dissociation constant (Ki) of 4 x 10–14 M.1-3 Uses include in vitro inhibition of ribonucle...

    transcription factor EC
    Synonyms TCFEC, TFE-C, TFEC-L, TFECL, bHLHe34, hTFEC-L
    Species Human (22797) , Species Mouse (21426) , Species Rat (26296) , Species domestic guinea pig (100717764) , Species naked mole-rat (101697964) , Species cow (539016) , Species sheep (101109437) , Species Zebrafish (556894) , Species chicken (417773) , Species dog (475292) , Species domestic cat (101085109)
    Summary: This gene encodes a member of the micropthalmia (MiT) family of basic helix-loop-helix leucine zipper transcription factors. MiT transcription factors regulate the expression of target genes by binding to E-box recognition sequences as homo- or heterodimers, and play roles in multiple cellular processes including survival, growth and differentiation. The encoded protein is a transcriptional activator of the nonmuscle myosin II heavy chain-A gene, and may also co-regulate target genes in osteoclasts as a heterodimer with micropthalmia-associated transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

    Research Essentials - Technical Library

    Buffer pKa/pH Tables and Formulas: Useful pH Ranges of Selected Biological Buffers (25 °C, 0.1M) Trizma Buffer Table - pH vs. Temperature Phosphate Buffer Table - 0.2M solution Commonly Used Electrophoresis Buffers Helpful Formulas DNA / Protein Electrophoresis and Troubleshooting Tables: Effective ...

    Competent Cell Selection Guide

    Sigma-Aldrich offers a range of Escherichia coli bacterial cells made competent with the highest efficiencies by optimized procedure specific to each strain. Choose from 24 new competent cells for a wide variety of applications, including protein expression, routine or difficult cloning, and library...

    Antibodies for Epigenetics Research

    Back to BioFiles v7 n3 Main Page Download BioFiles v7 n3 (3.97 Mb PDF) With a current portfolio of over 50,000 antibodies, Sigma is a leader in providing high-quality antibodies for DNA methylation, chromatin biology, transcriptional regulation, and cellular biology. All backed by our industry leadi...

    Balancing Histone/Protein Acetylation: Gene Regulation and Cancer Therapy

    • • Download PDF • Michigan State University, East Lansing, Michigan, USA A highly sophisticated mechanism organizes the 2-meter long human genome within a 6-μm wide nucleus. Up to 10,000-fold of compaction of the chromatin is achieved during mitosis, allowing faithful segregation of mitotic chromos...

    Dietary Antioxidants

    Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxidative metabolism of glucose in the mitochondria, superoxide anions (O2 –) are produced as a by-produ...

    The New Human Protein Atlas Web Portal | Biowire Winter 2011

    Subscribe to Biowire and eBiowire Biowire Winter 2011 — Knockout Rats — More Effective Pre-Clinical Models Table of Contents • Study Spotlights ○ The Unique Features of Prestige Antibodies® ○ The New Human Protein Atlas • Methods ○ microRNA Target Validation MISSION® 3’UTR Lenti GoClone™ and Human m...

    Tips for Cell Engineering using Cas9-GFP CRISPR plasmids

    Related Article Introduction to CRISPR A CRISPR/Cas-GFP Vector for Rapid Expression Verification View CRISPR Webinar CRISPR endonucleases have shown wide variation in their activity, even among multiple CRISPRs designed within close genomic proximity.1 For this reason, we highly recommend that you t...

    Troubleshooting - PCR Technologies Guide

    • Introduction and Historical Timelines • Polymerase Chain Reaction • Quantitative PCR • Digital PCR • Quantitative PCR and Digital PCR Detection Methods • PCR/qPCR/dPCR Assay Design • Sample Purification and Quality Assessment • Reverse Transcription • Assay Optimization and Validation • Data Analy...

    JAKs

    The Janus kinases were initially identified as a novel subfamily of 120-140 kDa cytoplasmic tyrosine kinases that uniquely contained two, tandem domains with homology to tyrosine kinase catalytic domains. Initial insights into their roles in signal transduction came from genetic studies of interfero...

    Antilipemic Agents

    Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage • 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors • Peroxisome Proliferator-Activated Receptor (PPAR) Agonists • Acyl–Coenzyme A:Cholesterol Acyltransferase (ACAT) Inhibitors Browse t...

    GenElute™ RNA/DNA/Protein Plus Purification Kit

    Product Description Sigma’s GenElute RNA/DNA/Protein Plus Purification Kit provides a rapid method for the isolation and purification of total RNA, genomic DNA and proteins sequentially from a single sample of cultured animal cells, small tissue samples, blood, bacteria, yeast, fungi or plants. The ...

    July 2000 RT-PCR

    A TECHNICAL APPLICATION NEWSLETTER VOL 1 July 2000 Molecular Biology Application Notes Sigma's New Enhanced Avian RT-PCR Kit by Erik Eastlund and Keming Song Sigma-Aldrich Corporation, St. Louis, MO, USA Introduction Reverse transcriptase-PCR (RT-PCR) is a powerful tool for gene expression analysis ...

    Total RNA Bacteria Purification Kit

    Sigma’s GenElute Bacterial Total RNA Purification Kit combines silica-membrane technology with a convenient spin column format for a rapid bind, wash and elute method to prepare high quality total RNA from both Gram-negative and Gram-positive bacteria. Cells are lysed and homogenized in a guanidine ...

    Ribonuclease Inhibitor - Recombinant, expressed in E. coli

    Ribonuclease Inhibitor, recombinant is derived from E. coli cells expressing a recombinant clone containing portions of the human placental ribonuclease inhibitor. The protein has a molecular mass of ~50 kDa by SDSPAGE.1 Inhibition of ribonuclease activity occurs by the formation of a tight, non-cov...

    PDGFR

    Platelet-derived growth factor (PDGF) is a family of disulfide-bonded dimeric molecules of A-, B-, C- and D-polypeptide chains (PDGF-AA, -AB, -BB, -CC and -DD). PDGF isoforms stimulate proliferation, survival and motility of connective tissue cells, and certain other cell types. PDGFs have important...

    Jan 01 Cell Biology

    A TECHNICAL APPLICATION NEWSLETTER Jan 01 Cell Biology Cell Biology Leptomycin B: A Powerful Antibiotic Tool for Studying Nuclear Transport By Ned Watson Sigma-Aldrich Corporation, St. Louis, MO, USA Introduction Leptomycin B (LMB) is an antibiotic with anti-fungal and anti-tumor activity that was f...

    TargeTron® Resources

    • Detailed Explanation of the TargeTron System • Diagram Overview of Method • TargeTron Algorithm • References The TargeTron Gene Knockout System provides optimized reagents and protocols for the rapid and specific disruption of bacterial genes by insertion of group II introns. Unlike conventional D...

    Alkaline Phosphatase Detection Kit, Fluorescence

    Catalog Number: APF Storage Temperature –20 °C Product Description Components Equipment and reagents required but not provided Precautions and Disclaimer Storage/Stability Procedure Troubleshooting Materials The gene for alkaline phosphatase (AP) commonly serves as a reporter gene and is used to det...

    qPCR Gene Expression/Copy Number/SNP Analysis Using Probe Detection Protocol

    The most common application for qPCR is the measurement of a gene transcript or copy number quantity relative to one or more reference genes using probe detection. The reactions may be designed such that each target is detected as a single reaction (simplex) or such that all probes can be added to a...

    MISSION™ shRNA Library: Next Generation RNA Interference

    • • Download PDF • The technology of RNA interference emerged in its earliest form following a 1998 study in Caenorhabditis elegans1 and has since rapidly evolved to its current form as a revolutionary tool for studying gene function, biological pathways, and the physiology of disease. Earlier studi...

    Stabilizing RNA at room temperature in RNAstable®

    Introduction RNAstable® is a novel preservation product developed to protect RNA from degradation during storage or shipment at ambient temperatures. The synthetic storage medium is based on the natural principles of anhydrobiosis (meaning “life without water”), a biological mechanism employed by so...