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Fluorous Chemistry
Fluorous Application Guide | ||
In addition to the extensive line of products, Sigma-Aldrich® and Fluorous Technologies, Inc. have prepared an array of tools to help you successfully implement fluorous techniques in your research. These tools include detailed application notes, a fluorous Cheminar™, ChemFiles, presentations, and literature references.
Application Notes (PDF)
Tags / Protecting Groups
- Tagging with F-Boc-ON: fluorous analogue of the Boc-ON acid-labile N-protecting group/tag (37 Kb PDF)
- FluoMar: solution-phase Marshall resin equivalent™ (167 Kb PDF)
- F-PMB-OH: fluorous propyl methoxy benzyl alcohol for tagging (80 Kb PDF)
- F-Cbz-OSu: fluorous benzyloxycarbonyloxy succinimide analogue; acid-labile N-protecting group/tag (35 Kb PDF)
- Using fluorous thiol as a tag (35 Kb PDF)
- Tagging with fluorous diisopropylsilane (TIPS analog) (37 Kb PDF)
Tags / Protecting Groups Products
| Description | FTI Product No. | S-A Product No. |
| F-Boc-ON | F017003 | 55118 |
| FluorMar | F017027 | 40829 |
| F-PMB-OH | F017006 | 97071 |
| F-Cbz-Osu | F017008 | 14944 |
| F-Thiol | F017023 | 08686 |
| F-TIPS analog | F017004 | 04537 |
Solution-phase Scavengers
- Nucleophile scavenging with fluorous isatoic anhydride (171 Kb PDF)
- Nucleophile scavenging with fluorous isocyanate (175 Kb PDF)
- Electrophile scavenging with fluorous thiol (42 Kb PDF)
Solution-phase Scavengers Products
| Description | FTI Product No. | S-A Product No. |
| F-Isatoic Anhydride | F017028 | 07172 |
| F-Isocyanate | F017032 | 18486 |
| F-Thiol | F017023 | 08686 |
Reagents and Catalysts
- Fluorous Mitsunobu strategy for facile separation of byproducts (63 Kb PDF)
- F-PPh3: Using fluorous triphenylphosphine (170 Kb PDF)
- Using the fluorous CDMT coupling reagent (146 Kb PDF)
- Using fluorous thiol to deprotect 2-nitrobenzenesulfonamides (188 Kb PDF)
- F-Sn=O: Selective sulfonylation of 1,2-diols using tin oxide as a catalyst (160 Kb PDF)
Reagents and Catalysts Products
| Description | FTI Product No. | S-A Product No. |
| Mitsunobu reaction | F002610 | 68333 |
| F-PPh3 | F017039 | 07026 |
| F-CDMT | F026171 | 672378 |
| F-Thiol | F017023 | 08686 |
| F-Sn=O | F026051 | 43482 |
F-SPE Cartridges
F-SPE Cartridges Products
| Description | FTI Product No. | S-A Product No. |
| 2 grams, 8 cc tube, 40 µm particle size | 801-0027S | 14196 |
| 5 grams, 10 cc tube, 40 µm particle size | 801-0058S | 00866 |
| 10 grams, 60 cc tube, 40 µm particle size | 801-0109S | 08967 |
| 20 grams, 60 cc tube, 40 µm particle size | 801-0209S | 08966, 06961 |
Presentations
- Fluorous 2007 Overview (1.34 Mb PDF)
- Fluorous Peptide Chemistry (725 b PDF)
- Fluorous Small Molecule Chemistry (641 Kb PDF)
- Fluorous Immobilization for Microarray Formation (1.29 Mb PDF)
For additional Fluorous Technologies, Inc. presentations, click here.
References
Download the Endnote database containing Fluorous References (more than 2,500 references). Please note that you’ll need a version of Endnote (.enl) to use this database.
Cheminar and ChemFiles
- Fluorous Cheminar™ — "Fluorous Chemistry for Synthesis, Separation and Enrichment"
- Fluorous Synthesis and Separation ChemFile (1.07 Mb PDF)
- Fluorous Peptide Synthesis ChemFile (1.25 Mb PDF)
- Fluorous Protection ChemFile (1.02 Mb PDF)