ChemFilesTitle Vol. 2, No. 2
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Introduction / Aldehydes / Brominated Compounds / Related Products / Reference Books

Aldehydes

Heterocycles / Boronic Acids / Salicylaldehyde-like / Acids & Esters / Arylaldehydes
Supported Reagents / CHO Functionalized Resins / Aldehyde Scavengers

 

Heterocycles

32,844-8

C4H4N2O

1g

45,612-8

C4H4N2O

1g; 5g

15,262-5

C5H3BrOS

5g; 25g; 100g

28,345-2

C5H3BrOS

5g; 25g

43,398-5

C5H3BrO2

1g; 10g

P7,340-4

C5H5NO

5g; 25g; 100g

39,215-4

C5H6N2O

5g

52,569-3

C6H4BrNO

1g; 10g

H4,080-7

C6H6O3

250mg; 1g; 5g

 53,306-8

C7H7NO2

5g

 55,988-1

C8H11ClN2O

25g

 51,874-3

C9H6BrNO

5g

53,307-6

C9H6ClNO

5g

49,344-9

C9H6O2

1g; 5g

12,944-5

C9H7NO

5g; 25g

51,383-0

C9H7NO

5g

39,011-9

C10H6ClNO

1g; 10g

40,202-8

C10H7NO3

1g

44,440-5

C10H8N2O

5g

13,413-9

C10H9NO

1g; 5g

26,243-9

C10H9NO

25g; 100g

51,112-9

C10H9NO

5g

M1,494-3

C10H9NO2

100mg; 1g

56,593-8

C11H8OS

1g; 5g

37,577-2

C11H9NO2

1g; 5g

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Boronic Acids
49,990-0

C5H5BO3S

1g; 5g

49,991-9

C5H5BO3S

1g; 5g

51,405-5

C5H5BO3S

1; 5gg

54,241-5

C5H5BO3S

1g; 5g

43,195-8

C7H7BO3

1g; 5g

43,196-6

C7H7BO3

1g; 5g

44,165-1

C7H7BO3

1g; 5g

51,225-7

C8H9BO4

5g

51,286-9

C8H9BO4

5g; 25g

 

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Salicylaldehyde-like
26,181-5

C7H4Cl2O2

5g; 25g

13,728-6

C7H5BrO2

25g; 100g

51,677-5

C7H5BrO2

5g

34,606-3

C7H5ClO2

500mg

44,770-6

C7H5ClO2

5g; 25g

31,980-5

C7H5FO2

250mg; 1g

52,627-4

C7H5FO2

1g

14,432-0

C7H5NO4

5g; 25g

15,616-7

C7H5NO4

1g; 10g

27,535-2

C7H5NO4

5g; 25g

52,742-4

C7H5NO4

1g; 5g

H4,810-7

C7H5NO4

5g; 25g

14,408-8

C7H6O2

50g; 250g

H1,980-8

C7H6O2

15g; 100g; 500g

S35-6

C7H6O2

100g; 500g; 1kg

52,681-9

C8H7FO3

1g

43,408-6

C8H7NO5

1g; 5g

N2,800-0

C8H7NO5

5g; 25g

31,691-1

C8H8O2

1g

44,455-3

C8H8O2

1g; 5g

45,466-4

C8H8O2

1g; 5g

12,080-4

C8H8O3

10g; 100g; 500g

14,368-5

C8H8O3

25g; 100g

14,686-2

C8H8O3

1g; 5g; 10g

16,069-5

C8H8O3

1g; 5g; 25g

V110-4

C8H8O3

2g; 100g; 500g

14,039-2

C9H10O2

1g; 5g

12,809-0

C9H10O3

5g; 100g

16,098-9

C9H10O3

50g

13,879-7

C9H10O4

250mg; 1g

25,871-7

C9H10O4

250mg; 1g

39,293-6

C9H10O4

250mg; 1g

S760-2

C9H10O4

5g; 25g; 100g

55083

C10H7NO2

1g; 5g

H4,535-3

C11H8O2

25g; 100g; 500g

22,568-1

C11H15NO2

5g; 25g

 

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Acids & Esters
G1,060-1

C2H2O3

10g; 25g; 100g

47723

C3H5NO3

5g

28,718-0

C4H6O3

1ml; 5ml

42,158-8

C5H5NO4

5g; 25g

15,727-9

C7H10O3

5g; 10g

68259

C7H10O3

50ml; 250ml

12,491-5

C8H6O3

10g; 25g; 100g

23,279-3

C8H6O3

1g; 5g

11,601-7

C8H6O3

25g; 100g

24,474-0

C9H8O3

1g, 5g

47749

C9H8O3

1g; 5g

15,215-3

C9H8O4

25g; 100g

47743

C9H8O4

5g; 25g

17,876-4

C10H8O3

1g; 5g; 25g

48,376-1

C10H17NO3

1g

48,378-8

C10H17NO3

1g

 

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Arylaldehydes
543314

C7H4FIO

1g

B5,700-1

C7H5BrO

10g; 25g

B5,720-6

C7H5BrO

25g; 100g

B5,740-0

C7H5BrO

10g; 25g; 100g

56,301-3

C8H5BrO3

50g

55,358-1

C8H7BrO3

5g; 25g

56,504-0

C8H7ClO2

1; 5g

53,673-3

C8H7FO2

1g; 5g

55,335-2

C9H9BrO3

1; 5g

 

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Supported Reagents

35,982-3 Chromic acid, polymer-supported,
20-50 mesh, ca. 2.5 mmol/g
5g; 25g; 100g

Polymer-supported reagent for the clean oxidation of primary and secondary alcohols to carbonyl compounds in high yields.1,2 Reagent for the synthesis of aldehydes and ketones from allylic and benzylic halides.3

References:

  1. Cainelli, G. et al. J. Am. Chem. Soc. 1976, 98, 6737.
  2. Wade, L.G.; Stell, L.M. J. Chem. Educ. 1980, 57, 438.
  3. Cardillo, G. et al. Tetrahedron Lett. 1976, 3985.

 

32,864-2 Borohydride, polymer-supported
(Amberlite IRA-400), 20-50 mesh, ca. 2.5 mmol/g
25g; 100g; 250g

Reduce aldehydes and ketones to alcohols.1

References:

  1. Yoon, N.M. et al. Tetrahedron Lett. 1983, 24, 5367.

 

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CHO Functionalized Resins

The following resins are useful for the solid-phase preparation of secondary sulfonamides, amides, ureas, carbamates, and feature dilute acid labile linkers.1-7
51,644-9 AMEBA resin,
1% DVB, 100-200 mesh, 1.0-1.5 mmol/g
1g; 5g; 25g
53,821-3 4-Benzyloxy-2,6-dimethoxybenzaldehyde, polymer-bound,
1% DVB, 100-200 mesh, 1.0-1.5 mmol/g
1g; 5g; 25g
51,627-9 3-Formyl-1-indoleacetic acid, polymer-bound,
1% DVB, 200-400 mesh, ca. 1.0 mmol/g
1g; 5g; 25g
53,242-8 Formylpolystyrene, 2% DVB, 100-200 mesh,
2.0-3.0 mmol/g
1g; 5g; 25g

 

References:
  1. Wilson, T.W. et al. Tetrahedron Lett. 1997, 38, 7151.
  2. Sarantakis, D. et al. Tetrahedron Lett. 1997, 38, 7325.
  3. Flygare, J.A. et al. J. Org. Chem. 1998, 63, 196.
  4. Bilodeau, M.T. et al. J. Org. Chem. 1998, 63, 2800.
  5. Estep, K.G. et al. J. Org. Chem. 1998, 63, 5300.
  6. Yan, B. et al. J. Comb. Chem. 2000, 2, 66.
  7. Cossey, J. et al. J Org. Chem 2001, 66, 7195.

 

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Aldehyde Scavengers

Selectively remove excess reagent and/or impurities using these scavenger resins.1-3
47,209-3 Ethylenediamine, polymer-bound,
1% DVB, 200-400 mesh, 2.5-3.0 mmol/g
5g; 25g
53,791-8 3-(Ethylenediamino)propyl-functionalized silica gel,
200-400 mesh, ca. 2.5 mmol/g
5g; 25g; 100g
47,367-7 Poly(styrene-co-divinylbenzene), aminomethylated,
2% DVB, 200-400 mesh, ca. 4 mmol/g
5g; 25g
36,425-8 3-Aminopropyl-functionalized silica gel,
200-400 mesh, ca. 1.0 mmol/g
10g; 50g; 250g
51,620-1 Sulfonyl amide, polymer-supported,
1% DVB, 100-200 mesh, 1.5-2.0 mmol/g
5g; 25g
53,793-4 2-Ethyl-benzenesulfonamide-functionalized silica gel,
200-400 mesh, 0.6-0.9 mmol/g
5g; 25g; 100g
53,232-0 p-Toluenesulfonyl hydrazide, polymer-bound,
1% DVB,100-200 mesh, ca. 2.5 mmol/g
1g; 5g; 25g
55,259-3 2-(4-Toluenesulfonyl hydrazino)ethyl functionalized silica gel,
200-400 mesh, ca. 2.0 mmol/g
5g; 25g; 100g

 

References:
  1. Flynn, D.L. et al. J. Am. Chem. Soc., 1997, 119, 4874.
  2. Chen, J., et al. Tetrahedron Lett. 1999, 40, 9195.
  3. Kaldor, S.W. et al. Tetrahedron Lett. 1996, 37, 7193.

 

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