Vol. 2, No. 8
New Nitrogen-Containing Heterocycles


Introduction / 5-Membered Heterocyclic Rings / 6-Membered Heterocyclic Rings
Mitsunaobu Reagents / Polymer-Supported Reagents / JandaJels™ / Functionalized Silica Gels

Polymer-Supported Reagents

The large, and tightly controlled particle size of Stratospheres™ makes them easy to handle, dispense, and filter. The high loading level ensures that polar solvents such as DMF and methanol can be used to good effect even though these products are manufactured from microporous polystyrene.


54,755-7

STRATOSPHERES™ PL-PIP (PIPERIDINE) RESIN, 50-100 MESH, 1% CROSS-LINKED

Supported tertiary amine.

5g; 25g


55,481-2

STRATOSPHERES™ PL-TBD(1,3,5-TRIAZABICYCLO[4.4.0]DEC-5-ENE) RESIN, 50-100 MESH, 1% CROSS-LINKED

Scavenger for phenols and peroxides.

5g; 25g


54,754-9

STRATOSPHERES™ PL-PPZ(PIPERIZINE) RESIN, 50-100 MESH, 1% CROSS-LINKED

Serves as a Knoevenagel catalyst; eliminates piperidine-derived byproducts and reduces transesterification when using alcohol as a solvent.

5g; 25g


56,487-7

SUCCINIMIDYL CARBONATE, POLYMER-BOUND,100-200 MESH, 1% DVB

5g; 25g


56,412-5

PIPERIDINE, POLYMER-BOUND, 100-200 MESH, MACROPOROUS [(PIPERDINOMETHYL)POLYSTYRENE]

Acid scavenger.

5g; 25g


55,519-3

SCAVENGEPORE&#reg; PHENETHYL PIPERIDINE, 40-70 MESH

Acid scavenger

5g; 25g


56,188-6

PIPERIDINE-4-CARBOXYLIC ACID ON TRIS (2-AMINOETHYL)AMINE RESIN, 1% DVB, 100-200 MESH [TRIS(ISONIPECOTYLAMINOETHYL)AMINE]

Acid scavenger

5g; 25g


54,936-3

IMIDAZOLE CARBONATE, POLYMER-BOUND TO WANG RESIN, 100-200 MESH, 1% CROSS-LINKED

This resin reacts rapidly with amines and Grignard reagents to provide the corresponding urethanes and esters. Efficient cleavage can be performed using TFA or hydrogenolysis.

1g; 5g


56,609-8

TEMPO, POLYMER-BOUND, 100-200 MESH [PS-TEMPO, (2,2,6,6-TETRAMETHYL-1-PIPERINYLOXY, FREE RADICAL), POLYMER-BOUND]

Starting material for Rasta Resin as well as a resin for solution-phase synthesis. A supported oxidizing reagent for the conversion of primary alcohols to aldehydes and secondary alcohols to ketones. The free radical is formed at 136:C.

1g; 5g