Potassium Trifluoroborates

 
Vol. 3, No. 3
Reagents for Suzuki Coupling
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Introduction / Boronic acids / Boronic acid Esters / Diboron Esters
Potassium Trifluoroborates / OSVB, Volume 3: Suzuki Coupling

Potassium Trifluoroborates

Alkyl, aryl, and alkenyl trifluoroborate salts are compelling alternatives to boronic acids in Suzuki coupling and in rhodium catalyzed carbon-carbon bond forming reactions. These salts are air and water stable, and in many cases eliminate the need to add either additional ligands or base for cross coupling. Whereas the boronic acids readily form cyclic anhydrides, these new salts do not form unwanted side products. In many cases, the trifluoroborate salt is more efficient and tolerant to functional groups than the corresponding boronic acids.

 

Potassium 3-thiophenetrifluoroborate Potassium 4-bromophenyltrifluoro-borate
57,157-1 C4H3BF3KS 1g; 5g 57,154-7 C6H4BBrF3K 1g; 5g
Potassium 2-bromophenyltrifluoro-borate Potassium 3-nitrophenyltrifluoro-borate
57,610-7 C6H4BBrF3K 1g; 5g 57,159-8 C6H4BF3KNO2 1g; 5g
Potassium phenyltrifluoroborate Potassium 4-(trifluoromethyl)phenyltri-fluoroborate
56,395-1 C6H5BF3K 1g; 5g 57,613-1 C7H4BF6K 1g; 5g
Potassium 4-formylphenyltrifluoro-borate Potassium benzyltrifluoroborate
57,609-3 C7H5BF3KO 1g; 5g 56,305-6 C7H7BF3K 1g; 5g
Potassium o-tolyltrifluoroborate Potassium p-tolyltrifluoroborate
57,612-3 C7H7BF3K 1g; 5g 57,155-5 C7H7BF3K 1g; 5g
Potassium 3-methoxyphenyltri-fluoroborate Potassium 3,5-bis(trifluoromethyl)-phenyltrifluoroborate
57,611-5 C7H7BF3KO 1g; 5g 57,156-3 C8H3BF9K 1g; 5g
Potassium trans-styryltrifluoroborate Potassium phenethyltrifluoroborate
57,615-8 C8H7BF3K 1g; 5g 56,309-9 C8H7BF3K 1g; 5g