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Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications across a wide range of therapeutic areas. However, recent publications often demonstrate the need for a researcher to attenuate or amplify the activity of their target compound without altering the steric bulk of the structure; thus, isosteres of the indole and purine rings have proven very valuable to synthetic and medicinal chemists. Aldrich Chemistry is pleased to offer a wide variety of these useful building blocks for your research. Browse through the lists below to find the target compounds you’re looking for. |
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