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Technology Spotlights
New MIDA Boronates
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MIDA Boronates: Stable Boronic Acid Surrogates for Classically Challenging Cross-Couplings
MIDA boronates are stable boronic acid surrogates used for Suzuki-Miyaura cross-coupling reactions. These reagents enable the coupling of historically unstable organoboron species; including those containing 2-heterocyclic, vinyl, and cyclopropyl moieties.
Benefits of MIDA Boronates:
- Bench-top and chromatographically stable
- Good solubility properties and monomeric in nature
- Controlled in-situ slow-release allows for the cross-coupling of classically challenging substrates
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Cross-Coupling of MIDA Boronates
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Stable MIDA Boronates from Aldrich
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| Product # |
Structure |
Name |
| 719390 |
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2-Pyridinylboronic acid MIDA ester |
| 723053 |
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6-Methoxypyridine-2-boronic acid MIDA ester |
| 723959 |
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6-Methylpyridinyl-2-boronic acid MIDA ester |
| 724629 |
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1-(Dimethylamino)pyrrole-2-boronic acid MIDA ester, 97 % |
| 717193 |
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1-(p-Toluenesulfonyl)pyrrole-2-boronic acid MIDA ester |
| 697443 |
 |
1-(Phenylsulfonyl)-2-indolylboronic acid MIDA ester, 96 % |
| 701017 |
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2-Furanylboronic acid MIDA ester, 97 % |
| 704547 |
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5-Formyl-2-furanboronic acid MIDA ester, 97 % H-NMR |
| 701106 |
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2-Benzofuranylboronic acid MIDA ester, 97 % |
| 708828 |
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2-Thiopheneboronic acid MIDA ester |
| 701092 |
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5-Bromo-2-thiophenylboronic acid MIDA ester, 95 %
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| 704415 |
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Vinylboronic acid MIDA ester, 97 % |
| 701831 |
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trans-1-Propenylboronic acid MIDA ester |
| 698199 |
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cis-1-Propenylboronic acid MIDA ester |
| 703478 |
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trans-2-Bromovinylboronic acid MIDA ester |
| 697311 |
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Cyclopropylboronic acid MIDA ester, 97 % |
| 710040 |
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Cyclobutylboronic acid MIDA ester, 97 % |
View a complete listing of MIDA Boronates from Sigma-Aldrich.
References:
- Gillis, E. P.; Burke, M. D. Aldrichimica Acta 2009, 131, 17. (X) Knapp, D. M.; Gillis, E. P.; Burke, M. D. J. Am. Chem. Soc. 2009, 131, 6961.
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