Os EnCat 40

Advantages of Os EnCat™ 40 Catalyst:

· Safer, easier to handle, and non-volatile
· Greater storage stability versus OsO₄
· Facile recovery of catalyst
· Low levels of Os metal in final product
· Catalyst can be recycled

Reactivity of Os EnCat

Application Data

Os EnCat^TM 40 has shown good catalytic activity in the dihydroxylations of acyclic and cyclic olefins of varying substitution patterns (Table I below). Catalyst efficiency is heightened by use of a single phase solvent in conjunction with the co-oxidant 4-methylmorpholine-N-oxide (NMO, 224286). Amounts of Os metal in the crude product mixture are normally in the 10-40 ppm range, which is acceptable for most pharmaceutical purity assays. To achieve optimum reaction rates, processes with Os EnCat^TM are normally performed at elevated temperatures. Os EnCat^TM 40 can be utilized in combination with chiral ligands such as [(DHQD)₂PHAL] (Aldrich product 392766) to induce stereoselective transformations. Os EnCat^TM 40 has also shown to be an effective catalyst for the oxidative cleavage of olefins to generate their respective carbonyl compounds under mild reaction conditions.

Dihydroxylation of Acyclic and Cyclic Olefins Using Os EnCat^TM 40*:

Table I. *Conditions: Olefin (1 mmol), N-methylmorpholine-N-oxide (1.5 mmol), solvent (10 mL).

Os EnCat™ 40 Experimental Guide (2.3 MB PDF)

Reference:

Microencapsulation of Osmium Tetroxide in Polyurea. Ley, S. V. et al. Org. Lett., 2003, 5, 185-187.