Chemical Synthesis

QuadraPure & QuadraSil

QuadraPure™ and QuadraSil™ metal scavengers offer a variety of complementary solutions for efficient removal and economic recovery of precious metal contamination from products and organic or aqueous process streams. The above picture shows a typical ‘before-and-after’ treatment of a metal catalyst solution (initial metal content 1000 ppm) at room temperature, by simple agitation with a metal scavenger.

Polymer and Silica-based Metal Scavengers

QuadraPure™

The QuadraPure™ collection consists of two ranges of functionalized polystyrene beads:

  • Macroporous, low-swell, robust beads for use in either in batch or flow processes.
  • Microporous, solvent swellable beads with high capacity intended largely for R&D application.

The above graphic illustrates the effect of treating a metal contaminated reaction mixture with different QuadraPure™ metal scavengers. The original reaction mixture (obtained from a hydrogenation reaction using Wilkinson’s catalyst) contained ~200 ppm Rh metal. Treatment with either of the three QuadraPures™ reduced Rh contamination by >99%.

Technical Information for Download (PDF format):

1) QuadraPure™ and QuadraSil™ Presentation (2.9 MB PDF)
2) QuadraPure™ Technical Flier (197 KB PDF)
3) QuadraPure™ User Guide (381 KB PDF)
4) ChemFiles 2007 Supplement 1: Encapsulated Catalysts and Metal Scavengers (624 KB PDF)

  Product #  Product Name Structure and Functional Group Examples of Metals Removed Add to Cart
Macroporous 655422 QuadraPure™ TU thiourea Pd, Pt, Ru, Rh, Au, Ag, Cu, Hg, Pb, Cd, Ni, Co, Fe, V, Zn
657026 QuadraPure™ IDA imino diacetate Cu, Al, Ga, In, V, Pb, Ni, Zn, Cd, Be, Mn, Sr, Ba, Co, Fe
657611 QuadraPure™ AMPA aminomethyl phosphonic Fe, Cu, Ni, Al, Co, V
668591 QuadraPure™ BZA benzyl amine Rh, Pd, Cu, Co, Ni
668605 QuadraPure™ BDZ imidazole Rh, Co, Pd, Ni
668583 QuadraPure™ EDA amine Pd in basic media and with phosphines, Co, Ni, Rh
668575 QuadraPure™ DET thiol Pd in acidic media and with phosphines, Co, Fe, Ni, Rh
Microporous 657654 QuadraPure™ IMDAZ imidazolylpropyl amino Pd, Ru, Os, Co, Ni, V, Rh, Cu, Fe, Sn
657662 QuadraPure™ MPA mercaptophenyl amino Pd, Pt, Rh, Ni, Ru, Cu, Sn, Ag, Au, Cd, Hg, Pb
657646 QuadraPure™ AEA aminoethyl amino Pd, Rh, V, Cu, Fe
551473 QuadraPure™ AK activated ketone (2,4-butanedione) None. Scavenger for primary amines and hydrazines

659428 QuadraPure™ Metal Scavengers Kit I (5 g samples of QuadraPure™ TU, IDA, AMPA, IMDAZ, MPA, and AEA)
681547 QuadraPure™ Metal Scavengers Kit II (5 g samples of all QuadraPure™ scavengers with the exception of QuadraPure™ AK, total of 10 samples)

References:
1) Ley, S. V. et al. Org. Lett. 2006, 8, 5231.
2) Jones, C. W. et al. Adv. Synth. Catal. 2006, 348, 1207.
3) Weck, M. et al. Adv. Synth. Catal. 2006, 348, 2101.
4) Pitts, M. R. et al. Org. Process Res. Dev. 2007, 11, 477.
5) Ley, S. V. et al. Org. Process Res. Dev. 2007, 11, 458.

QuadraSilTM

The QuadraSils™ scavengers offer extremely rapid removal of metal catalyst residues. The QuadraSils™ are based on high-quality spherical silica beads with well defined porosity which can be used in aqueous or organic solution and in batch or flow processes.

The image below illustrates the effect of treating a reaction mixture containing Grubbs’ catalyst in toluene (~ 595 ppm Ru). Addition of QuadraSils™ resulted in removal of >99% of the Ru metal, with QuadraSil™ AP reaching this low level in 1.5 hours.

Technical Information for Download (PDF format):

1) QuadraPure™ and QuadraSil™ Presentation (2.9 MB PDF)
2) QuadraSil™ Technical Flier (799 KB PDF)
3) QuadraSil™ User Guide (529 KB PDF)
4) ChemFiles 2007 Supplement 1: Encapsulated Catalysts and Metal Scavengers (624 KB PDF)

 
Product #  Product Name Structure and Functional Group Examples of Metals Removed Add to Cart
679534 QuadraSil™ AP amino propyl Pd, Ru, Rh, Cu, Fe, Co, Ni, Zn, Pb, Cd, Hg
679526 QuadraSil™ MP mercaptopropyl Pd (with or without phosphines), Rh, Cu, Ru, Pt, Pb, Ag, Hg
679518 QuadraSil™ MTU methylthiourea Pd, Rh, Cu, Ru, Pb, Fe, Co, Ag, Au, Hg, Pt
679496 QuadraSil™ TA triamine Pd, Rh, Co, Cu, Fe, Ru, Cd, Au, V, Zn, Pt, Pb
680427 QuadraSil™ Metal Scavengers Kit I (5 g samples of each QuadraSil™)



Carbon-based Scavengers for Trace Organics

QuadraPure™ C: Coming Soon!

QuadraPureTM C is a totally synthetic carbon adsorbent for removal of soluble organics from polar solvents, including water. It is composed of 0.3 to 0.8 mm mechanically-stable beads which are free-flowing and dust free. The adsorbent has a high surface area and capacity, is thermally stable, and is effective at removing a number of commonly-occurring organic contaminants including those responsible for color and odor. Potential applications include cGMP manufacture of APIs and intermediates and clean-up of macromolecules such as peptides.

Easier to handle No reactor contamination or filter caking/blocking, dust free
Cleaner products Adsorption of trace contaminants, no “carry over” of particulate carbon.
Cleaner waste streams Removal of trace organic material from waste streams
Improved reproducibility Totally synthetic carbon (>99.9%) gives excellent batch-to- batch performance
Fast, efficient process Good filtration characteristics, fast flow rates
Process intensification Can be used in batch processes, loose packed beds, or as a pre-packed cartridge
Safer No dust or flammable solids generated

Technical Information for Download (PDF format):

1) QuadraPure™ C Technical Flier (1.0 MB PDF)
2) QuadraPure™ C Application in Peptide Conjugate Purification (621 KB PDF)
 

Product #  Product Name Description Add to Cart
684295 QuadraPure™ C Scavenger for trace organic impurities