QuadraPure & QuadraSil

QuadraPure™ and QuadraSil™ metal scavengers offer a variety of complementary solutions for efficient removal and economic recovery of precious metal contamination from products and organic or aqueous process streams. The above picture shows a typical ‘before-and-after’ treatment of a metal catalyst solution (initial metal content 1000 ppm) at room temperature, by simple agitation with a metal scavenger.

Polymer and Silica-based Metal Scavengers

QuadraPure™

The QuadraPure™ collection consists of two ranges of functionalized polystyrene beads:

• Macroporous, low-swell, robust beads for use in either in batch or flow processes.
  
• Microporous, solvent swellable beads with high capacity intended largely for R&D application.

The above graphic illustrates the effect of treating a metal contaminated reaction mixture with different QuadraPure™ metal scavengers. The original reaction mixture (obtained from a hydrogenation reaction using Wilkinson’s catalyst) contained ~200 ppm Rh metal. Treatment with either of the three QuadraPures™ reduced Rh contamination by >99%.

Technical Information for Download (PDF format):

1) QuadraPure™ and QuadraSil™ Presentation (2.9 MB PDF)
2) QuadraPure™ Technical Flier (197 KB PDF)
3) QuadraPure™ User Guide (381 KB PDF)
4) ChemFiles 2007 Supplement 1: Encapsulated Catalysts and Metal Scavengers (624 KB PDF)

	Product #	Product Name	Structure and Functional Group		Examples of Metals Removed	Add to Cart
	655422	QuadraPure™ TU		thiourea	Pd, Pt, Ru, Rh, Au, Ag, Cu, Hg, Pb, Cd, Ni, Co, Fe, V, Zn
	657026	QuadraPure™ IDA		imino diacetate	Cu, Al, Ga, In, V, Pb, Ni, Zn, Cd, Be, Mn, Sr, Ba, Co, Fe
	657611	QuadraPure™ AMPA		aminomethyl phosphonic	Fe, Cu, Ni, Al, Co, V
	668591	QuadraPure™ BZA		benzyl amine	Rh, Pd, Cu, Co, Ni
	668605	QuadraPure™ BDZ		imidazole	Rh, Co, Pd, Ni
	668583	QuadraPure™ EDA		amine	Pd in basic media and with phosphines, Co, Ni, Rh
	668575	QuadraPure™ DET		thiol	Pd in acidic media and with phosphines, Co, Fe, Ni, Rh
	657654	QuadraPure™ IMDAZ		imidazolylpropyl amino	Pd, Ru, Os, Co, Ni, V, Rh, Cu, Fe, Sn
	657662	QuadraPure™ MPA		mercaptophenyl amino	Pd, Pt, Rh, Ni, Ru, Cu, Sn, Ag, Au, Cd, Hg, Pb
	657646	QuadraPure™ AEA		aminoethyl amino	Pd, Rh, V, Cu, Fe
	551473	QuadraPure™ AK		activated ketone (2,4-butanedione)	None. Scavenger for primary amines and hydrazines

References:
1) Ley, S. V. et al. Org. Lett. 2006, 8, 5231.
2) Jones, C. W. et al. Adv. Synth. Catal. 2006, 348, 1207.
3) Weck, M. et al. Adv. Synth. Catal. 2006, 348, 2101.
4) Pitts, M. R. et al. Org. Process Res. Dev. 2007, 11, 477.
5) Ley, S. V. et al. Org. Process Res. Dev. 2007, 11, 458.

QuadraSil^TM

The QuadraSils™ scavengers offer extremely rapid removal of metal catalyst residues. The QuadraSils™ are based on high-quality spherical silica beads with well defined porosity which can be used in aqueous or organic solution and in batch or flow processes.

The image below illustrates the effect of treating a reaction mixture containing Grubbs’ catalyst in toluene (~ 595 ppm Ru). Addition of QuadraSils™ resulted in removal of >99% of the Ru metal, with QuadraSil™ AP reaching this low level in 1.5 hours.

Technical Information for Download (PDF format):

1) QuadraPure™ and QuadraSil™ Presentation (2.9 MB PDF)
2) QuadraSil™ Technical Flier (799 KB PDF)
3) QuadraSil™ User Guide (529 KB PDF)
4) ChemFiles 2007 Supplement 1: Encapsulated Catalysts and Metal Scavengers (624 KB PDF)

Product #	Product Name	Structure and Functional Group		Examples of Metals Removed	Add to Cart
679534	QuadraSil™ AP		amino propyl	Pd, Ru, Rh, Cu, Fe, Co, Ni, Zn, Pb, Cd, Hg
679526	QuadraSil™ MP		mercaptopropyl	Pd (with or without phosphines), Rh, Cu, Ru, Pt, Pb, Ag, Hg
679518	QuadraSil™ MTU		methylthiourea	Pd, Rh, Cu, Ru, Pb, Fe, Co, Ag, Au, Hg, Pt
679496	QuadraSil™ TA		triamine	Pd, Rh, Co, Cu, Fe, Ru, Cd, Au, V, Zn, Pt, Pb
680427	QuadraSil™ Metal Scavengers Kit I (5 g samples of each QuadraSil™)

Carbon-based Scavengers for Trace Organics

QuadraPure™ C: Coming Soon!

QuadraPure^TM C is a totally synthetic carbon adsorbent for removal of soluble organics from polar solvents, including water. It is composed of 0.3 to 0.8 mm mechanically-stable beads which are free-flowing and dust free. The adsorbent has a high surface area and capacity, is thermally stable, and is effective at removing a number of commonly-occurring organic contaminants including those responsible for color and odor. Potential applications include cGMP manufacture of APIs and intermediates and clean-up of macromolecules such as peptides.

Technical Information for Download (PDF format):

1) QuadraPure™ C Technical Flier (1.0 MB PDF)
2) QuadraPure™ C Application in Peptide Conjugate Purification (621 KB PDF)