Chemical Synthesis

Symphos Ligands


A new class of phenyl-backbone derived P,O-ligands (Symphos) were developed by Symyx Technologies in collaboration with professor Fu and co-workers.1 These new ligands proved to be suitable for general palladium/ligand catalyzed Suzuki transformations of aryl halides. This new system demonstrated its efficiency by catalyzing the cross-coupling of aryl boronic acids and aryl chlorides containing electron poor and electron rich substituents with good overall yields. The catalysis was carried out with Pd(dba)2 and Symphos with CsF in toluene at 105 °C with yields up to 97%.



Entry
R-B(OH)2
Ar-Cl
Yield (%)
1
96
2
97
3
91
4
94

Reference:

  1. Bei, X. et al. J. Org. Chem. 1999, 64, 6797.

 



Product No.
Product Name
Structure
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SYMPHOS
2-(2-Dicyclohexylphosphinophenyl)-1,3-dioxolane