Building Blocks for SuFEx: The Next Click Reaction

Sulfonyl Fluorides allow for the rapid inclusion of building-block type moieties into Lead compounds. The “Click II” reaction is, like its Alkyne-Azide predecessor, fast and quantitative, with the sulfonyl fluoride group reacting predictably with nucleophiles, all the while remaining inert to oxidation, reduction, thermolysis and other reactive conditions.

Pendant functionalization of your Lead Compound can be achieved with ethenesulfonyl fluoride (ESF Cat. No. 746959), a Michael -acceptor to covalently link nitrogen, oxygen and carbon nucleophiles in your Lead to a pendant sulfonyl fluoride group, ripe for further functionalization and diversification.

Bi-Functional Sulfonyl Fluorides

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Molecular Formula

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ALD00170 1, 2-Benzenedisulfonyl fluoride 97% C6H4F2O4S2
ALD00172 1,3-Benzenedisulfonyl fluoride 95% C6H4F2O4S2
ALD00364 4-(2-Bromoacetyl)benzenesulfonyl fluoride 95% (GC) C8H6BrFO3S
ALD00028 4-(Bromomethyl)benzenesulfonyl fluoride 97% C7H6BrFO2S
900605 3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride ≥95% C12H14BrFO2SSi
ALD00204 2-Chloro-5-fluorosulfonyl-4-fluorobenzoic acid 95% C7H3ClF2O4S
ALD00190 2-Cyanobenzenesulfonyl fluoride C7H4FNO2S
ALD00214 3-Cyanobenzenesulfonyl fluoride 95% C7H4FNO2S
ALD00096 4-Cyanobenzenesulfonyl fluoride 98% (GC) C7H4FNO2S
531413 2,2-Difluoro-2-(fluorosulfonyl)acetic acid 97% C2HF3O4S
746959 Ethenesulfonyl fluoride 95% C2H3FO2S
ALD00038 3-(Fluorosulfonyl)benzoic acid 95% (HPLC) C7H5FO4S
224189 4-(Fluorosulfonyl)benzoic acid 95% C7H5FO4S
136387 4-(Fluorosulfonyl)benzoyl chloride technical grade, 90% C7H4ClFO3S
ALD00168 3-(Fluorosulfonyl)-2-thiophenecarboxylic acid methyl ester 95% C6H5FO4S2
900601 3-Formyl-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride ≥95% C12H13FO3SSi
ALD00124 4′-Methoxy-[1,1′-biphenyl]-4-sulfonyl fluoride C13H11FO3S
390755 Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate 97% C3H3F3O4S
ALD00024 2-(2-Propyn-1-yloxy)ethanesulfonyl fluoride 96% C5H7FO3S

Mono-Functionalized Sulfonyl Fluorides

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Description

Molecular Formula

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ALD00176 4-(Acetylamino)benzenesulfonyl fluoride 95% C8H8FNO3S
282332 Benzenesulfonyl fluoride 99% C6H5FO2S
ALD00126 [1,1′-Biphenyl]-4-sulfonyl fluoride 95% C12H9FO2S
ALD00086 2-Bromobenzenesulfonyl fluoride 95% (GC) C6H4BrFO2S
ALD00212 3-Bromobenzenesulfonyl fluoride 95% (GC) C6H4BrFO2S
ALD00146 4-Bromo-benzenesulfonyl fluoride 95% C6H4BrFO2S
ALD00222 4-Bromo-2-chlorobenzenesulfonyl fluoride 95% C6H3BrClFO2S
ALD00188 4-Bromo-2,6-dichlorobenzenesulfonyl fluoride 95% (GC) C6H2BrCl2FO2S
ALD00200 2-Bromo-4,6-difluorobenzenesulfonyl fluoride 95% (GC) C6H2BrF3O2S
ALD00072 2-Bromo-4-fluorobenzenesulfonyl fluoride 95% (GC) C6H3BrF2O2S
ALD00224 4-Bromo-2-fluorobenzenesulfonyl fluoride 95% (NMR) C6H3BrF2O2S
ALD00058 5-Bromo-2-methoxybenzenesulfonyl fluoride 95% C7H6BrFO3S
ALD00194 4-Bromo-3-methylbenzenesulfonyl fluoride 95% C7H6BrFO2S
ALD00156 5-Bromo-2-thiophenesulfonyl fluoride 95% (GC) C4H2BrFO2S2
ALD00066 4-Bromo-2-(trifluoromethoxy)benzenesulfonyl fluoride 95% C7H3BrF4O3S
ALD00210 2-Bromo-5-(trifluoromethyl)benzenesulfonyl fluoride 95% (GC) C7H3BrF4O2S
ALD00134 1-Butanesulfonyl fluoride 95% C4H9FO2S
ALD00192 2-Chlorobenzenesulfonyl fluoride 95% C6H4ClFO2S
ALD00090 3-Chlorobenzenesulfonyl fluoride 95% C6H4ClFO2S
ALD00128 4-Chlorobenzenesulfonyl fluoride 95% C6H4ClFO2S
ALD00122 4′-Chloro-[1,1′-biphenyl]-4-sulfonyl fluoride 95% C12H8ClFO2S
ALD00082 3-Chloro-2-fluorobenzenesulfonyl fluoride 95% C6H3ClF2O2S
ALD00070 4-Chloro-2-fluorobenzenesulfonyl fluoride 95% C6H3ClF2O2S
ALD00198 3-Chloro-4-methylbenzenesulfonyl fluoride 95% (GC) C7H6ClFO2S
ALD00052 4-Chloro-3-nitrobenzenesulfonyl fluoride 95% (HPLC) C6H3ClFNO4S
ALD00158 5-Chloro-2-thiophenesulfonyl fluoride 95% C4H2ClFO2S2
ALD00162 Cyclopropanesulfonyl fluoride 95% C3H5FO2S
ALD00144 2,4-Dibromobenzenesulfonyl fluoride 95% C6H3Br2FO2S
ALD00054 2,5-Dibromobenzenesulfonyl fluoride 95% C6H3Br2FO2S
ALD00080 2,3-Dichlorobenzenesulfonyl fluoride 95% (GC) C6H3Cl2FO2S
ALD00068 2,4-Dichlorobenzenesulfonyl fluoride C6H3Cl2FO2S
ALD00060 2,5-Dichlorobenzenesulfonyl fluoride 95% (GC) C6H3Cl2FO2S
ALD00202 2,6-Dichlorobenzene-1-sulfonyl fluoride 95% C6H3Cl2FO2S
ALD00138 3,4-Dichlorobenzenesulfonyl fluoride 95% C6H3Cl2FO2S
ALD00154 4,5-Dichloro-2-thiophenesulfonyl fluoride 95% C4HCl2FO2S2
ALD00062 2,5-Difluorobenzenesulfonyl fluoride 95% C6H3F3O2S
ALD00148 2,3-Dihydro-1,4-benzodioxin-6-sulfonyl fluoride 95% C8H7FO4S
ALD00064 2,5-Dimethoxybenzenesulfonyl fluoride 95% C8H9FO4S
ALD00140 3,4-Dimethoxybenzenesulfonyl fluoride 95% C8H9FO4S
ALD00206 3,5-Dimethylbenzenesulfonyl fluoride 95% (H-NMR) C8H9FO2S
ALD00142 Ethanesulfonyl fluoride 95% C2H5FO2S
ALD00178 2-Fluorobenzenesulfonyl fluoride 95% C6H4F2O2S
ALD00074 4-Fluoro-2-methylbenzenesulfonyl fluoride 95% (GC) C7H6F2O2S
178950 Methanesulfonyl fluoride 98% CH3FO2S
ALD00094 3-Methoxybenzenesulfonyl fluoride C7H7FO3S
ALD00130 4-Methoxybenzenesulfonyl fluoride 95% C7H7FO3S
ALD00078 2-Methoxy-4-nitrobenzenesulfonyl fluoride 95% C7H6FNO5S
ALD00180 2-Methylbenzenesulfonyl fluoride 95% C7H7FO2S
ALD00088 3-Methylbenzenesulfonyl fluoride 95% C7H7FO2S
ALD00120 4′-Methyl-[1,1′-biphenyl]-4-sulfonyl fluoride 95% (GC) C13H11FO2S
ALD00116 4-(1-Methylethyl)benzenesulfonyl fluoride C9H11FO2S
ALD00152 1-Methyl-1H-imidazole-2-sulfonyl fluoride 95% C4H5FN2O2S
ALD00046   2-Methyl-5-nitrobenzenesulfonyl fluoride 95% C7H6FNO4S
ALD00218 4-Methyl-3-nitrobenzenesulfonyl fluoride 95% (GC) C7H6FNO4S
ALD00150 1-Naphthalenesulfonyl fluoride 95% C10H7FO2S
ALD00056 2-Naphthalenesulfonyl fluoride 95% C10H7FO2S
ALD00048 2-Nitrobenzenesulfonyl fluoride 95% C6H4FNO4S
ALD00092 3-Nitrobenzenesulfonyl fluoride C6H4FNO4S
ALD00036 4-Nitrobenzenesulfonyl fluoride 95% C6H4FNO4S
ALD00042 3-Nitrophenylsulfonyl fluoride 97% C6H4FNO4S
ALD00084 2-Nitro-α-toluenesulfonyl fluoride C7H6FNO4S
319732 Perfluoro-1-butanesulfonyl fluoride 96% C4F10O2S
319724 Perfluoro-1-octanesulfonyl fluoride 95% (sum of isomers) C8F18O2S
ALD00132 4-Phenoxybenzenesulfonyl fluoride 95% C12H9FO3S
ALD00044 2-Phenylethenesulfonyl fluoride 95% C8H7FO2S
ALD00118 4-Propylbenzenesulfonyl fluoride C9H11FO2S
473839 Tetrafluoro-2-(tetrafluoro-2-iodoethoxy)ethanesulfonyl fluoride 97% C4F9IO3S
ALD00160 2-Thiophenesulfonyl fluoride 95% C4H3FO2S2
117455 p-Toluenesulfonyl fluoride 98% C7H7FO2S
ALD00196 2,4,6-Trichlorobenzenesulfonyl fluoride 95% C6H2Cl3FO2S
ALD00220 2,3,4-Trifluorobenzenesulfonyl fluoride 95% C6H2F4O2S
ALD00136 2,4,6-Triisopropylbenzenesulfonyl fluoride C15H23FO2S
ALD00050 2,4,6-Trimethylbenzenesulfonyl fluoride 95% C9H11FO2S