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C-H Activation

Sigma-Aldrich is the premier source for the catalysts, auxiliaries and oxidants required for the functionalization of select sp2- and sp3 C-H bonds. These processes are often chemoselective and proceed with high levels of atom-economy.

Baran Diversinates

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ALD00296 Sodium adamantylsulfinate C10H15NaO2S
ALD00462 Sodium 2-(2-Bromophenyl)-1,1-difluoroethanesulfinate 95% C8H6BrF2NaO2S
ALD00458 Sodium 2-(3-Bromophenyl)-1,1-difluoroethanesulfinate C8H6BrF2NaO2S
ALD00288 Sodium tert-butylsulfinate C4H9NaO2S
ALD00230 Sodium 4,4-difluorocyclohexanesulfinate C6H9F2NaO2S
745405 Sodium 1,1-difluoroethanesulfinate C2H3F2NaO2S
746118 Sodium difluoroheptylazidosulfinate 95% C7H12F2N3NaO2S
792446 Sodium 1,1-difluoro-4-(2-methyl-1,3-dioxolan-2-yl)butane-1-sulfinate C8H13F2NaO4S
ALD00290 Sodium 2,2-dimethylpropylsulfinate C5H11NaO2S
ALD00294 Sodium ethylsulfinate C2H5NaO2S
ALD00234 Sodium tetrahydrofuransulfinate ≥90% (H-NMR) C4H7NaO3S
ALD00232 Sodium tetrahydropyransulfinate C5H9NaO3S
790184 Sodium 1-(trifluoromethyl)cyclopropanesulfinate C4H4F3NaO2S
ALD00238 Sodium trifluoropropylsulfinate C3H4F3NaO2S
790796 Zinc benzylsulfinate C14H14O4S2Zn
792187 Zinc bis[(phenylsulfonyl)methanesulfinate] 95% (H-NMR) C14H14O8S4Zn
790788 Zinc chloroethanesulfinate 95% (NMR) C4H8Cl2O4S2Zn
791105 Zinc chloromethanesulfinate 95% (H-NMR) C2H4Cl2O4S2Zn
767840 Zinc difluoromethanesulfinate 95% C2H2F4O4S2Zn
745480 Zinc isopropylsulfinate 95% C6H14O4S2Zn
791040 Zinc n-propylsulfinate 95% (H-NMR) C6H14O4S2Zn
745499 Zinc trifluoroethanesulfinate C4H4F6O4S2Zn
771406 Zinc trifluoromethanesulfinate C2F6O4S2Zn

Catalysts

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222380 Allylpalladium(II) chloride dimer 98% Green Alternative C6H10Cl2Pd2
684821 1,2-Bis(phenylsulfinyl)ethane palladium(II) acetate Green Alternative C18H20O6PdS2
730459 (2S,2′S-(−)-[N,N′-Bis(2-pyridylmethyl)]-2,2′-bipyrrolidinebis(acetonitrile)iron(II) hexafluoroantimonate Green Alternative C24H32F12FeN6Sb2
662623 Bis[rhodium(α,α,α′,α′-tetramethyl-1,3-benzenedipropionic acid)] 96% C32H40O8Rh2
335002 Carbonyldihydridotris(triphenylphosphine)ruthenium(II) C55H47OP3Rh
685062 (1,5-Cyclooctadiene)(methoxy)iridium(I) dimer C18H30Ir2O2
343706 Dichloro(p-cymene)ruthenium(II) dimer Green Alternative C20H28Cl4Ru2
683213 Dichloro(p-cymene)ruthenium(II) dimer 97% C20H28Cl4Ru2
379573 Iron(III) phthalocyanine chloride Dye content ~95 % C32H16ClFeN8
900285 MCAT-53 C13H17Cl2NaO6Ru2
520764 Palladium(II) acetate ≥99.9% trace metals basis C4H6O4Pd
721611 Palladium pivalate 97% C10H18O4Pd
299685 Palladium(II) trifluoroacetate 97% C4F6O4Pd
756741 PCy3 Pd G2 95% C30H43ClNPPd
338370 Pentamethylcyclopentadienylrhodium(III) chloride dimer 97% C20H30Cl4Rh2
686891 Pentamethylcyclopentadienylrhodium(III) chloride dimer C20H30Cl4Rh2
482285 Rhodium(II) acetate dimer 99.99% trace metals basis C8H12O8Rh2
442100 Rhodium(II) octanoate, dimer C32H60O8Rh2
725455 Rhodium(II) triphenylacetate dimer as complex with dichloromethane C80H60O8Rh2 · CH2Cl2
10452 Ruthenium(III) chloride trihydrate technical Cl3Ru · 3H2O
L511749 Schafer′s Ti-Amidate Catalyst AldrichCPR C23H34N3OTi
S5506 Sodium nitrate ReagentPlus®, ≥99.0% NNaO3
237213 Sodium nitrite ACS reagent, ≥97.0% NNaO2
471143 Tetrakis[1-[[4-alkyl(C11-C13)phenyl]sulfonyl]-(2R)-pyrrolidinecarboxylate]dirhodium(II)  
470449 Tetrakis[1-[[4-alkyl(C11-C13)phenyl]sulfonyl]-(2S)-pyrrolidinecarboxylate]dirhodium(II)  
223662 Tris(triphenylphosphine)ruthenium(II) dichloride 97% C54H45Cl2P3Ru

Ligands and Auxiliaries

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A16300 N-Acetylglycine ReagentPlus®, 99% C4H7NO3
L511269 2,2′-Azanediyldibenzonitrile AldrichCPR C14H9N3
ALD00382 1,5-Bis[4-(trifluoromethyl)phenyl]-1,4-pentadien-3-one C19H12F6O
15380 Boc-Ala-OH ≥99.0% (TLC) C8H15NO4
359653 Boc-Ile-OH 98% C11H21NO4
15480 Boc-Phe-OH ≥99.0% (T) C14H19NO4
15451 Boc-Tle-OH ≥99.0% (T) C11H21NO4
15528 Boc-Val-OH ≥99.0% (T) C10H19NO4
ALD00510 2-Carbomethoxynorbornene C9H12O2
15450 N,N′-Dimethylurea (sym.), ≥99% (from N) C3H8N2O
ALD00002 Li-Quinoline Ligand C14H15NO
ALD00004 Li-Yu t-Butyl Quinoline 95% C18H23NO
P42800 2-Picolinic acid ReagentPlus®, 99% C6H5NO2
T71803 Pivalic acid 99% C5H10O2
802166 2-(Pyridin-2-yl)isopropyl amine 95% (GC) C8H12N2
ALD00376 Shi-Yu MPAA Ligand C17H31NO4
791369 Tang-Yu Auxiliary 97% C9H6FNO3
162884 3,4,7,8-Tetramethyl-1,10-phenanthroline ≥98% C16H16N2
ALD00378 Wasa-Yu MPAA Ligand C18H22Cl3F2NO4
ALD00506 Yu Borylation Ligand ≥95% C11H11NO2
ALD00508 Yu Fluorination Ligand C16H19NO
791806 Yu-Wasa Auxiliary 97% C7H2F7N

Building Blocks

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ALD00093 3-Acetoxy-2,6-diiodobenzoic acid C9H6I2O4
L511986 1,4-Benzenedicarboxylic acid, 2,6-diiodo-, 4-methyl ester AldrichCPR C9H6I2O4
ALD00348 Boc-3-[3,4-bis(trifluoromethyl)phenyl]-L-alanine ≥95% (HPLC) C16H17F6NO4
ALD00352 Boc-2-methoxy-L-phenylalanine 97% C15H21NO5
L511889 2-Bromo-6-iodobenzoic acid AldrichCPR C7H4BrIO2
L511943 4-Chloro-2,6-diiodobenzoic acid AldrichCPR C7H3ClI2O2
L511870 2-Chloro-6-iodobenzoic acid AldrichCPR C7H4ClIO2
ALD00400 2-Chloro-6-iodobenzoic acid 95% C7H4ClIO2
L511897 4-Chloro-2-iodo-6-methylbenzoic acid AldrichCPR C8H6ClIO2
L511935 2,6-Diiodobenzoic acid AldrichCPR C7H4I2O2
L511919 2,6-Diiodo-3-methylbenzoic acid AldrichCPR C8H6I2O2
L511978 2,6-Diiodo-4-methylbenzoic acid AldrichCPR C8H6I2O2
L511951 4-Fluoro-2,6-diiodobenzoic acid AldrichCPR C7H3FI2O2
L511900 4-Fluoro-2-iodo-6-methylbenzoic acid AldrichCPR C8H6FIO2
ALD00027 2-Iodo-4,6-difluoro-benzeneacetic acid AldrichCPR C8H5F2IO2
ALD00025 2-Iodo-6-methoxy-benzeneacetic acid AldrichCPR C9H9IO3
ALD00021 2-Iodo-1-Naphthaleneacetic acid AldrichCPR C12H9IO2
ALD00023 2-Iodo-6-(trifluoromethyl)-benzeneacetic acid AldrichCPR C9H6F3IO2
ALD00029 2-(6-Methoxy-3-iodo-2-napthyl)acetic acid AldrichCPR C13H11IO3

Oxidants

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662283 Bis(tert-butylcarbonyloxy)iodobenzene 97% C16H23IO4
178721 (Diacetoxyiodo)benzene 98% C10H11IO4
439312 1-Fluoro-2,4,6-trimethylpyridinium tetrafluoroborate ≥95% C8H11BF5N
738115 1-Fluoro-2,4,6-trimethylpyridinium triflate 95% C9H11F4NO3S
339296 Manganese(III) fluoride 99.9% trace metals basis F3Mn
216224 Potassium persulfate ACS reagent, ≥99.0% K2O8S2
439479 Selectfluor® fluorinating reagent >95% in F+ active Green Alternative C7H14B2ClF9N2

Surfactants

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763896 DL-α-Tocopherol methoxypolyethylene glycol succinate Green Alternative  
733857 DL-α-Tocopherol methoxypolyethylene glycol succinate solution 2 wt. % in H2O Green Alternative  
763918 DL-α-Tocopherol methoxypolyethylene glycol succinate solution 5 wt. % in H2O Green Alternative