TC RNA Phosphoramidite

Synthesize RNA oligonucleotides with more then 100 bases

Sigma-Aldrich extends its robust Proligo Reagents portfolio with the new TC RNA Phosphoramidite product line. Developed by Agilent Technologies and distributed through Sigma-Aldrich, these highly regarded, innovative monomers allow for faster, more efficient RNA based oligo manufacturing and the potential to build longer RNA oligos (>100 bases). TC RNA Phosphoramidites streamline the deprotection process resulting in consistently highl quality products, offering time and cost savings.

Key Features of 2′O-TC RNA Phosphoramidites
  • Reduced coupling time 3 minutes with ETT Activator 0.25M compared to 15 minutes of TBDMS RNA
  • High coupling efficiency
  • One-step downstream process with neat Ethylenediamine
  • Cleavage and deprotection within 2hours at ambient temperature
  • No need of any fluoride component
  • No need for desalting of oligos required
  • Enables manufacturing of long RNA oligomers
  • High yields of final oligo, best results have been archived using a buffer system

DMT-2′O-TC-rA(bz) Phosphoramidite

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A211630 DMT-2′O-TC-rA(bz) Phosphoramidite C52H59N8O10PS2 configured for ABI
 
A211680 DMT-2′O-TC-rA(bz) Phosphoramidite C52H59N8O10PS2 configured for PerkinElmer
configured for PolyGen
 
A211640 DMT-2′O-TC-rA(bz) Phosphoramidite C52H59N8O10PS2 configured for MerMade
 

DMT-2′O-TC-rC(ac) Phosphoramidite

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C213630 DMT-2′O-TC-rC(ac) Phosphoramidite C46H57N6O11PS2 configured for ABI
 
C213680 DMT-2′O-TC-rC(ac) Phosphoramidite C46H57N6O11PS2 configured for PerkinElmer
configured for PolyGen
 
C213640 DMT-2′O-TC-rC(ac) Phosphoramidite C46H57N6O11PS2 configured for MerMade
 

DMT-2′O-TC-rG(ib) Phosphoramidite

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G211630 DMT-2′O-TC-rG(ib) Phosphoramidite C49H61N8O11PS2 configured for ABI
 
G211680 DMT-2′O-TC-rG(ib) Phosphoramidite C49H61N8O11PS2 configured for PerkinElmer
configured for PolyGen
 
G211640 DMT-2′O-TC-rG(ib) Phosphoramidite C49H61N8O11PS2 configured for MerMade
 

DMT-2′O-TC-rU Phosphoramidite

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U211630 DMT-2′O-TC-rU Phosphoramidite C44H54N5O11PS2 configured for ABI
 
U211680 DMT-2′O-TC-rU Phosphoramidite C44H54N5O11PS2 configured for PerkinElmer
configured for PolyGen
 
U211640 DMT-2′O-TC-rU Phosphoramidite C44H54N5O11PS2 configured for MerMade