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Tetrazine/Strained-alkene Click Chemistry Reagents

The reaction of 1,2,4,5 tetrazines with strained alkenes has been applied as a rapid bioorthogonal click chemistry reaction for biological labeling and cell detection applications among others. This reaction procedes rapidly via an inverse electron demand [4 + 2] Diels-Alder cycloaddition to yield a stable covalent linkage without the need for a catalyst and the only byproduct is dinitrogen. When using trans-cyclooctene, this reaction is orders of magnitude faster than azide-cyclooctyne based click chemistry and has therefore found use in applications where low concentrations of reactants are desired or faster kinetics are needed.

Product #

Structure

Description

Material Type

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761591 (4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine hydrochloride 95%  
764396 (E)-Cyclooct-4-enol  
764523 (E)-Cyclooct-4-enyl 2,5-dioxo-1-pyrrolidinyl carbonate  
764701 2,5-Dioxo-1-pyrrolidinyl 5-[4-(1,2,4,5-tetrazin-3-yl)benzylamino]-5-oxopentanoate ≥90%  
764493 5-[4-(1,2,4,5-Tetrazin-3-yl)benzylamino]-5-oxopentanoic acid 97%  
776173 5-Norbornene-2-acetic acid succinimidyl ester 97%  
772828 5-Norbornene-2-endo-acetic acid  
790435 TCO PEG4 succinimidyl ester  
790451 TCO-amine HCl salt  
790443 TCO-PEG3-maleimide