Pyridyne and Indolyne Precursors

Pyridines and indoles are commonly found motifs in a number of biologically relevant targets. Pyridyne and indolyne intermediates are reactive species that can provide, upon trapping with a nucleophilic reagent, several novel N-heterocyclic based compounds. The Garg group has collaborated with Sigma-Aldrich to provide the following pyridine and indolyne precursors, where the corresponding reactive intermediate can be generated under the presence of fluoride and can be reacted with a variety of trapping reagents.

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L511641 5-Bromo-4-(trimethylsilyl)pyridin-3-yl trifluoromethanesulfonate AldrichCPR C9H11BrF3NO3SSi
795666 Garg 5-bromo-3,4-pyridyne precursor 95% C9H11BrF3NO3SSi
795674 3-(Trimethylsilyl)pyridin-2-yl trifluoromethanesulfonate 95% C9H12F3NO3SSi
795658 Garg 3,4-pyridine precursor 97% C9H12F3NO3SSi
798320 2-Bromo-6-(trimethylsilyl)phenyl triflate 95% C10H12BrF3O3SSi
797693 2-Chloro-6-(trimethylsilyl)phenyl triflate 95% C10H12ClF3O3SSi
L511625 4-(Trimethylsilyl)-1H-indol-5-yl trifluoromethanesulfonate AldrichCPR C12H14F3NO3SSi
795569 Garg 4,5-indolyne precusor 95% C12H14F3NO3SSi