Reproducibility: Validated Products

Reproducibility: Attaining the same results in a different set of hands.

Validating an experiment′s reproducibility and accuracy are the foundations of scientific research. Recently, the scientific community at large has voiced concerns about the recurring inability to replicate procedures with consistent results.

Typically, innovative research is published by the contributing lab(s) without other researchers validating the procedures. At times, unique conditions make it difficult to emulate certain data/results. This poses problems for naturally skeptical scientists, demanding a higher confidence of scientific testimonies.

The obligation of publishing replicable studies propels the disciplined understanding of science. Thus, in an effort to legitimize reagents, catalysts, etc., Sigma-Aldrich is now highlighting products found in our catalog whose use has been shown to be reproducible. Whether through 3rd-party publications, through citations in OrgSyn, or through Protocols written by our own Research & Development team, premier research will be identified and acclaimed. Sigma-Aldrich stands behind the ethical need for reproducibility, as it supports our philosophy of enabling science and improving the quality of life.

Click here to learn more about Sigma-Aldrich′s Focus on Reproducibility

Verified by OrgSyn

Organic Syntheses provides highly accredited articles to validate reagents and procedures.

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Molecular Formula

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682101 Bis(trimethylaluminum)-1,4-diazabicyclo[2.2.2]octane adduct C12H30Al2N2
742937 1,4-Diazabicyclo[2.2.2]octane bis(sulfur dioxide) adduct ≥95% (sulfur, elemental analysis) C6H12N2O4S2
677183 (S)-(–)-α,α-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether 95% C20H27NOSi
579726 Grubbs Catalyst 1st Generation 97% C43H72Cl2P2Ru
513210 (S)-(−)-2-Methyl-2-propanesulfinamide 97% C4H11NOS

Verified By 3rd-Party Application

3rd-Party Applications validate a reagent by confirming published findings in a different lab to achieve the same results (within a 10% tolerance).

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Molecular Formula

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745537 4-(Acetylamino)-2,2,6,6-tetramethyl-1-oxo-piperidinium tetrafluoroborate 97% C11H21BF4N2O2
771082 Grubbs Catalyst Z-Selective C32H41N3O4Ru
792454 Palau′Chlor® 95% C5H8ClN3O4
L511730 (2R)-2-Phenyl-3,4-dihydro-2H-pyrimido[2,1-b][1,3]benzothiazole AldrichCPR C16H14N2S
733857 DL-α-Tocopherol methoxypolyethylene glycol succinate solution 2 wt. % in H2O Green Alternative  

Verified By Sigma-Aldrich R&D Protocol

Sigma-Aldrich Protocols are designed to both highlight and give authenticity to innovative products in our catelog.

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747599 Boxed reaction: Buchwald-Hartwig in Lipshutz Surfactant Green Alternative  
747904 Boxed reaction: Heck Reaction in Lipshutz Surfactant Green Alternative  
747912 Boxed reaction: Sonogashira Reaction in Lipshutz Surfactant Green Alternative  
747602 Boxed reaction: Suzuki coupling in Lipshutz Surfactant Green Alternative  
337331 Dichloro(1,5-cyclooctadiene)ruthenium(II), polymer 95% Green Alternative C8H12Cl2Ru ]n
656577 1,3-Diisopropylimidazolium chloride 97% Green Alternative C9H17ClN2
742724 Dimethyl (1-diazo-2-oxopropyl)phosphonate solution ~10% in acetonitrile (H-NMR), ≥96% (HPLC) C5H9N2O4P
745405 Sodium 1,1-difluoroethanesulfinate C2H3F2NaO2S
673951 Tricyclopentylphosphine tetrafluoroborate 95% Green Alternative C15H28BF4P