Carreira Spirocyclic Building Blocks

Spirocyclic modules containing four-membered rings are currently of growing interest to discovery chemists. Aldrich Chemistry is pleased to offer a suite of spirocyclic building blocks in collaboration with Professor Dr. Erick Carreira and SpiroChem that includes assorted spiro[3.3]heptanes and spiro[3.4]octanes. Using these building blocks affords the synthesis of spirocyclic compounds that creatively exploit three dimensions, providing access to not only innovative sets of scaffolds in medicinal chemistry but also underexplored regions in chemical space.

Spirocyclic Building Blocks

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797464 7-Amino-5-oxa-2-azaspiro[3.4]octane-2-carboxylic acid 1,1-dimethylethyl ester C11H20N2O3
797588 7-Amino-5-thia-2-azaspiro[3.4]octane-2-carboxylic acid-5,5-dioxide 1,1-dimethylethyl ester 95% C11H20N2O4S
797405 6-Benzhydryl-3,3-difluoro-1,6-diazaspiro[3.3]heptane hydrochloride salt 95% C18H19ClF2N2
797480 1-Benzyl-6-tosyl-1,6-diazaspiro[3.3]heptan-3-amine C19H23N3O2S
797499 1-Benzyl-6-tosyl-1,6-diazaspiro[3.3]heptan-3-ol 95% C19H22N2O3S
797502 1-Benzyl-6-tosyl-1,6-diazaspiro[3.3]heptan-3-one 95% C19H20N2O3S
797421 2-Boc-8-amino-5-oxa-2-azaspiro[3.4]octane 95% C11H20N2O3
797626 2-Boc-8-amino-5-thia-2-azaspiro[3.4]octane 5,5-dioxide 95% C11H20N2O4S
797472 2-Boc-6-hydroxy-8-oxa-2-azaspiro[3.4]octane ≥95% C11H19NO4
797510 6-Boc-1-oxa-6-azaspiro[3.3]heptan-3-amine 95% C10H18N2O3
797545 6-Boc-1-oxa-6-azaspiro[3.3]heptan-3-one C10H15NO4
795895 2-(2-Boc-5-oxa-2-azaspiro[3.4]octan-7-yl)acetic acid C13H21NO5
797596 2-Boc-7-oxo-5-oxa-2-azaspiro[3.4]octane 95% C11H17NO4
797456 2-Boc-8-oxo-5-oxa-2-azaspiro[3.4]octane 95% C11H17NO4
797413 2-(tert-Butoxycarbonyl)-5-oxa-2-azaspiro[3.4]octane-7-carboxylic acid C12H19NO5
797618 2-(tert-Butoxycarbonyl)-5-thia-2-azaspiro[3.4]octane-8-carboxylic acid 5,5-dioxide 95% C12H19NO6S
797529 tert-Butyl 3-hydroxy-1-oxa-6-azaspiro[3.3]heptane-6-carboxylate C10H17NO4
797448 tert-Butyl-8-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate 95% C11H19NO4
797162 tert-Butyl 8-hydroxy-6-thia-2-azaspiro[3.4]octane-2-carboxylate 6,6-dioxide 95% C11H19NO5S
797154 tert-Butyl 8-oxo-5-thia-2-azaspiro[3.4]octane-2-carboxylate 5,5-dioxide C11H17NO5S
797561 7-Hydroxy-5-thia-2-azaspiro[3.4]octane-2-carboxylic acid-5,5-dioxide 1,1-dimethylethyl ester C11H19NO5S

Starting Materials for Spirocyclic Building Blocks

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792586 tert-Butyl 3-(2-ethoxy-2-oxoethylidene)azetidine-1-carboxylate 95% C12H19NO4
792578 Methyl 1-Boc-azetidine-3-carboxylate 95% C10H17NO4
793868 1-[(4-Methylphenyl)sulfonyl]-3-azetidinone 95% C10H11NO3S