The ability to fine-tune the reaction conditions (temperature, solvents, ligands, bases and other additives) of palladium catalysts makes palladium catalysis an extremely versatile tool in organic chemical synthesis. Furthermore, palladium catalysts have a very high tolerance of various functional groups and often are able to provide excellent stereo- and regiospecificity, which helps to avoid the need for the introduction of protecting groups. This highly versatile group of catalysts is known for carbon bond forming reactions (primarily C-C, C-O, C-N and C-F), such as: Heck coupling, Suzuki coupling, Stille coupling, Hiyama coupling, Sonogashira coupling, Negishi coupling, Buchwald-Hartwig amination just to name a few.

In heterogeneous catalysis, palladium catalysts such as the Lindlar catalyst (or Lindlar′s Palladium) have also seen a lot of successful applications. For example, the Lindlar catalyst is highly efficient at facilitating selective hydrogenations, which include the conversion of triple bonds to cis-double bonds, monohydrogenation of polyolefins, and hydrogenation of azides to amines.

Sigma-Aldrich welcomes you to review our extensive offering of highly versatile homogeneous and heterogeneous palladium catalysts. For even greater convenience in purification and post-reaction cleanup, we have also included a selection of supported Pd catalysts as well as a full line of recyclable and immobilized Pd Encat® catalysts that are suitable for various bond-formation and hydrogenation/reduction reactions.
Sigma-Aldrich provides the following Application Guide for Palladium Catalyzed Cross-Coupling Reactions, detailing catalyst applications to coupling reactions.
Application Guide for Palladium Catalyzed Cross-Coupling Reactions
Buchwald-Hartwig Amination Reaction
Heck Reaction
Negishi Coupling Reaction
Sonogashira Coupling Reaction
Stille Coupling Reaction
Suzuki Coupling Reaction