Sulfonamides/Sulfinamides

Sulfonamides are any amide of a sulfonic acid, i.e., RS(=O)2NR′2. Sulfinamides are amides of sulfinic acid and contain a sulfur-oxygen double bond and a sulfur-nitrogen single bond. Sulfonamides exhibit biological activity, such as a moiety in receptor ligands and binding dynamics. Sulfonamide derivatives can also demonstrate synthetic applicability, such as the ability to directly introduce a protected nitrogen functionality into a molecule. Sulfinamides are commonly reacted with aldehydes to provide chiral amines (one of many uses of chiral sulfinimines) upon addition of organometallic reagents and deprotection. Developed by Ellman, these chiral sulfinamides have found widespread use in diastereoselective alkylations, the synthesis of protected chiral amines, the Strecker synthesis of α-alkyl α-amino acids, and the preparation of novel ligands for asymmetric Lewis acid catalysis.

Learn More about Sulfonamides and Sulfinamides
Sulfonyl Chlorides and Sulfonamides
Asymmetric Aldol Reaction Using Chiral Sulfonamide Ligands
Asymmetric Oxidation
Chiral Phosphoric Acids
BINOL and Derivatives
Asymmetric Allylic Alkylation
Ellman′s Sulfinamides
S-Chirogenic Auxiliaries

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638455 Trifluoromethanesulfonamide 95% CH2F3NO2S
CDS007250 Methylsulfamoyl chloride AldrichCPR CH4ClNO2S
64275 Methanesulfonamide ≥97.0% (CHN) CH5NO2S
663727 2,2,2-Trichloroethoxysulfonamide 97% C2H4Cl3NO3S
CDS007313 ethylsulfamoyl chloride AldrichCPR C2H6ClNO2S
674060 Cyclopropanesulfonamide 97% C3H7NO2S
CDS010101 ethyl(methyl)sulfamoyl chloride AldrichCPR C3H8ClNO2S
CDS007305 Isopropylsulfamoyl chloride AldrichCPR C3H8ClNO2S
753122 Calcium(II) bis(trifluoromethanesulfonimide) 95% C4CaF12N2O8S4
753424 Magnesium bis(trifluoromethanesulfonimide) C4F12MgN2O8S4
86055 4-Sulfamoylbutyric acid technical, ≥90% (T) C4H9NO4S
560871   2-Methyl-2-propanesulfinamide 97%, racemic C4H11NOS
681326 2-(Trimethylsilyl)ethanesulfonamide 90% C5H15NO2SSi
753416 Scandium(III) trifluoromethanesulfonimide C6F18N3O12S6Sc
559547 2,4,6-Trichlorobenzenesulfonamide 97% C6H4Cl3NO2S
559660 4-Bromo-2-chlorobenzenesulfonamide 97% C6H5BrClNO2S
559679 2-Bromo-4-fluorobenzenesulfonamide 97% C6H5BrFNO2S
563625   4-Bromo-2-fluorobenzenesulfonamide C6H5BrFNO2S
559687 4-Bromo-3-fluorobenzenesulfonamide C6H5BrFNO2S
714518 2,5-Dibromobenzenesulfonamide 97% C6H5Br2NO2S
559601 5-Chloro-2-fluorobenzenesulfonamide C6H5ClFNO2S
563617 3,5-Dichlorobenzenesulfonamide 97% C6H5Cl2NO2S
553883 2,4-Difluorobenzenesulfonamide 96% C6H5F2NO2S
553875 2,5-Difluorobenzenesulfonamide 97% C6H5F2NO2S
542709 2,6-Difluorobenzenesulfonamide 97% C6H5F2NO2S
559571 3,4-Difluorobenzenesulfonamide 97% C6H5F2NO2S
559563 3,5-Difluorobenzenesulfonamide 97% C6H5F2NO2S
644609 2-Bromobenzenesulfonamide 97% C6H6BrNO2S
563609 3-Bromobenzenesulfonamide 97% C6H6BrNO2S
16374 4-Bromobenzenesulfonamide ≥99.0% (T) C6H6BrNO2S
538450 2-Chlorobenzenesulfonamide 98% C6H6ClNO2S
C24191 4-Chlorobenzenesulfonamide 98% C6H6ClNO2S
542717 2-Fluorobenzenesulfonamide 97% C6H6FNO2S
542725 3-Fluorobenzenesulfonamide 97% C6H6FNO2S
542733 4-Fluorobenzenesulfonamide 98% C6H6FNO2S
228907 2-Nitrobenzenesulfonamide 98% C6H6N2O4S
296422 3-Nitrobenzenesulfonamide 99% C6H6N2O4S
120502 4-Nitrobenzenesulfonamide 97% C6H6N2O4S
682470 2-Amino-5-bromobenzenesulfonamide 97% C6H7BrN2O2S
CDS007881 2-chloro-4-sulfamoylaniline AldrichCPR C6H7ClN2O2S
108146 Benzenesulfonamide ≥98% C6H7NO2S
308560 4-Amino-6-chloro-1,3-benzenedisulfonamide 98% C6H8ClN3O4S2
245887 2-Aminobenzenesulfonamide 98% C6H8N2O2S
724696 3-Aminobenzenesulfonamide 98% C6H8N2O2S
CDS003887 4-sulfonamidophenylhydrazine hydrochloride AldrichCPR C6H10ClN3O2S
CDS013404 dipropylsulfamoyl chloride AldrichCPR C6H14ClNO2S
559717 2-Bromo-4-(trifluoromethyl)benzenesulfonamide 97% C7H5BrF3NO2S
559695 2-Bromo-5-(trifluoromethyl)benzenesulfonamide C7H5BrF3NO2S
559725 4-Bromo-3-(trifluoromethyl)benzenesulfonamide 97% C7H5BrF3NO2S
479845 2-Chloro-4-fluoro-5-sulfamoylbenzoic acid 96% C7H5ClFNO4S
25619 4-Chloro-3-nitro-5-sulfamoylbenzoic acid technical, ≥90% (S) C7H5ClN2O6S
CDS012176 4-fluoro-2-(trifluoromethyl)benzenesulfonamide AldrichCPR C7H5F4NO2S
CDS012212 4-fluoro-3-(trifluoromethyl)benzenesulfonamide AldrichCPR C7H5F4NO2S
CDS011339 4-bromo-3-sulfamoyl-benzoic acid AldrichCPR C7H6BrNO4S
CDS007171 2-chloro-5-sulfamoylbenzoic acid AldrichCPR C7H6ClNO4S
293598 4-Chloro-3-sulfamoylbenzoic acid 98% C7H6ClNO4S
545805 4-Chloro-2-hydroxy-5-sulfamoylbenzoic acid 96% C7H6ClNO5S
563552 2-(Trifluoromethyl)benzenesulfonamide 97% C7H6F3NO2S
563560 3-(Trifluoromethyl)benzenesulfonamide 97% C7H6F3NO2S
563579 4-(Trifluoromethyl)benzenesulfonamide 97% C7H6F3NO2S
CDS003758 2-(Trifluoromethoxy)benzenesulfonamide AldrichCPR C7H6F3NO3S
563587 4-(Trifluoromethoxy)benzenesulfonamide 97% C7H6F3NO3S
563633   2-Cyanobenzenesulfonamide C7H6N2O2S
708240 3-Cyanobenzenesulfonamide 97% C7H6N2O2S
C11804 4-Sulfamoylbenzoic acid 97% C7H7NO4S
CDS004016 3-bromo-N-Methylbenzenesulphonamide AldrichCPR C7H8BrNO2S
CDS003742 4-bromo-N-Methylbenzenesulphonamide AldrichCPR C7H8BrNO2S
680508 N-(4-Bromophenyl)methanesulfonamide 97% C7H8BrNO2S
CDS005716 5-Bromo-2-methoxybenzenesulfonamide AldrichCPR C7H8BrNO3S
559644 3-Fluoro-4-methylbenzenesulfonamide 97% C7H8FNO2S
559652 4-Fluoro-2-methylbenzenesulfonamide 97% C7H8FNO2S
513938 N-(2-Fluorophenyl)methanesulfonamide 98% C7H8FNO2S
09575 4-Amino-6-(trifluoromethyl)benzene-1,3-disulfonamide technical, ≥96% (HPLC) C7H8F3N3O4S2
694495 4-Methyl-3-nitrobenzenesulfonamide 97% C7H8N2O4S
257990 o-Toluenesulfonamide 99% C7H9NO2S
236330 p-Toluenesulfonamide ReagentPlus®, ≥99% C7H9NO2S
105902 p-Toluenesulfonamide reagent grade, 98% C7H9NO2S
544655 4-Methoxybenzenesulfonamide 97% C7H9NO3S
548278 N-(3-Aminophenyl)methanesulfonamide C7H10N2O2S
CDS013353 cyclohexyl(methyl)sulfamoyl chloride AldrichCPR C7H14ClNO2S
CDS010729 perfluorooctanesulfonamide AldrichCPR C8H2F17NO2S
CDS000954 3-(Trifluoromethyl)thiobenzamide AldrichCPR C8H6F3NS
CDS001126 4-(Trifluoromethyl)thiobenzamide AldrichCPR C8H6F3NS
CDS017010 2-fluoro-5-methylsulfamoyl-benzoic acid AldrichCPR C8H8FNO4S
245232 Methyl 2-(aminosulfonyl)benzoate 98% C8H9NO4S
86020 Sulfacetamide sodium salt monohydrate ≥98.0% (dried material, T) C8H9N2NaO3S · H2O
CDS003774 2-bromo-N,N dimethylbenzenesulfonamide AldrichCPR C8H10BrNO2S
CDS003622 3-bromo-N,N-dimethylbenzenesulphonamide AldrichCPR C8H10BrNO2S
CDS013455 benzyl(methyl)sulfamoyl chloride AldrichCPR C8H10ClNO2S
86018 Sulfacetamide ≥98.0% (NT) C8H10N2O3S
275247 4-(2-Aminoethyl)benzenesulfonamide 99% C8H12N2O2S
647179 4-Amino-N-methyl-α-toluenesulfonamide 97% C8H12N2O2S
CDS012079 1-[4-(aminomethyl)phenyl]methanesulfonamide hydrochloride AldrichCPR C8H13ClN2O2S
CDS014188 4-(2-aminoethyl)benzenesulfonamide monohydrochloride AldrichCPR C8H13ClN2O2S
CDS013449 dibutylsulfamoyl chloride AldrichCPR C8H18ClNO2S
CDS012083 N-[1-(aminomethyl)cyclohexyl]methanesulfonamide hydrochloride AldrichCPR C8H19ClN2O2S
86718 N,N,N′,N′-Tetraethylsulfamide ≥99.0% C8H20N2O2S
694967 N-(2-Aminoethyl)-4-(trifluoromethyl)benzenesulfonamide 97% C9H11F3N2O2S
522279 Methyl 2-methoxy-5-sulfamoylbenzoate 98% C9H11NO5S
CDS007158 4-bromomethyl-N,N-dimethyl-benzenesulfonamide AldrichCPR C9H12BrNO2S
CDS005720 5-bromo-N,N-dimethyl-2-methoxybenzenesulfonamide AldrichCPR C9H12BrNO3S
634077 Naphthalene-2-sulfonamide 97% C10H9NO2S
A9584 N-Acetoxy-N-acetyl-4-chlorobenzenesulfonamide ≥98% C10H10ClNO5S
546666 N-Succinyl sulfanilamide sodium salt hydrate C10H11N2NaO5S · xH2O
B90653 N-Butylbenzenesulfonamide 99% C10H15NO2S
39225 5-(Dimethylamino)-1-naphthalenesulfonamide for fluorescence, ≥98.5% (TLC) C12H14N2O2S
218898 5-(Dimethylamino)-1-naphthalenesulfonamide 99% C12H14N2O2S
CDS010839 4-fluoro-N-(4-hydroxyphenyl)-N-Methylbenzene-1-sulfonamide AldrichCPR C13H12FNO3S
371777 N-(4-Aminophenyl)-4-methylbenzenesulfonamide 99% C13H14N2O2S
522325 2-Amino-N-cyclohexyl-N-methylbenzenesulfonamide 97% C13H20N2O2S
730386 N-(4-Bromobenzylidene)-p-toluenesulfonamide 97% C14H12BrNO2S
712418 N-(4-Chlorobenzylidene)-4-methylbenzenesulfonamide 97% C14H12ClNO2S
479853 N-Benzyl-4-chloro-5-sulfamoylanthranilic acid 98% C14H13ClN2O4S
730394 N-Benzylidene-p-toluenesulfonamide 97% C14H13NO2S
712426 N-(4-Methylbenzylidene)-4-methylbenzenesulfonamide 97% C15H15NO2S
712434 N-(4-Methoxybenzylidene)-4-methylbenzenesulfonamide 97% C15H15NO3S
463442 5-Chloro-2-methoxy-N-[2-(4-sulfamoylphenyl)ethyl]benzamide 95% C16H17ClN2O4S
699306 Pentacene-N-sulfinyl-tert-butylcarbamate 99% (HPLC) C27H23NO3S