Selective oxidative transformations of various functional groups with environmentally friendly and easily accessible oxidants can be readily achieved with the use of a proper ruthenium catalyst. Ruthenium catalysis can be a very powerful tool in synthetic chemistry for selective catalysis of such oxidative transformations as: asymmetric epoxidation of alkenes, generation of dioxygen species, dihydroxylation of olefins, and oxidative dehydrogenation of alcohols.
Ruthenium catalysts are also widely employed in metathesis reactions, with Grubbs′ catalysts being the most well-known in the field of olefin metathesis. The wide popularity of Grubb′s catalysts can be explained by their high tolerance of various functional groups, and their high stability in the air and a plethora of solvents.
Sigma-Aldrich is proud to be the exclusive research scale supplier of Materia′s ruthenium metathesis catalysts, including first- and second-generation Grubbs and Hoveyda-Grubbs catalysts. Our wide offering of Materia′s ruthenium catalysts contains products with unique reactivities and tailored initiation rates. These ruthenium catalysts allow for metathesis reactions to be performed at low temperatures, as well as for the formation of tetrasubstituted olefins via cross metathesis.