Amine protection is often an essential part of synthetic organic chemistry as well as peptide synthesis. The abundance of amines in organic molecules makes the use of amine protecting groups commonplace in many synthetic schemes. Amines are nucleophilic and basic in nature and therefore can require protection to mask these properties during a chemical reaction. Effective protecting groups are able to be added to and easily removed from the compound being synthesized. In the case of amine protection, after the amine sensitive reaction is complete and the protecting group removed, the amine is regenerated as it was prior to adding the protecting group.
Sigma-Aldrich is pleased to offer you a variety of options for your amine protection needs. Our collection includes products to help add common amine protecting groups such as Fmoc, Boc, and p-nitrophenyl moieties to your compound of interest. These groups are of particular use in peptide synthesis where amino acid protection is needed to shield the various functional groups and N-terminus of the peptide. Orthogonal protection of amines is needed in many cases as well in order to selectively protect and deprotect different groups on the same compound. This can be achieved through the use of Boc (base stable, acid labile) along with Fmoc (acid stable, base labile) amine protecting groups, a method frequently used in peptide synthesis.
