Boronic Acids

Boronic acids, such as phenylboronic acid, are important in organic synthesis and medicinal chemistry because of their versatility as synthetic intermediates in the preparation of complex molecules. Sigma-Aldrich is pleased to present its comprehensive list of boronic acids for use in such reactions as the powerful carbon-carbon bond-forming Suzuki-Miyaura palladium catalyzed cross-coupling reaction, the Stille coupling, Sonogashira coupling, Chan-Lam coupling, Lieberskind-Strogl coupling, conjugate additions, homologations, and electrophilic allyl shifts.

Boronic acids have biological applications as well, such as inhibition of serine proteases. The Raines group described pendant boronic acids enhancing the cytosolic delivery of a protein toxin by forming boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells.

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