Thioureas

Thioureas are organosulfur compounds structurally similar to ureas, except the oxygen atom is replaced by a sulfur atom to constitute the S=C(NH2)2 moiety. Jacobsen‘s research group has developed a range of chiral thioureas that are versatile and effective organocatalysts. A range of latent nucleophiles can be added to mostly imine-type electrophiles in excellent enantiomeric excesses and, in general, with a broad substrate scope. Thiourea derivatives represent a promising class of anticancer agents because of their inhibitory activity against protein tyrosine kinases (PTKs), human sirtuin type proteins (SIRT1 and SIRT2), topoisomerase II8 and DNA repair synthesis. These enzymatic inhibitory activities coupled with the antiviral, antimalarial, antibacterial and antiinflammatory activities of thioureas have therefore attracted considerable pharmaceutical interest in thiourea derivatives as an important pharmocophore in synthetic medicinal chemistry.

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Jacobsen Thioureas

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T8656 Thiourea ACS reagent, ≥99.0% CH4N2S
    • 69350 N-Methylthiourea purum, ≥98.0% (CHN) C2H6N2S
    • M84607 N-Methylthiourea 97% C2H6N2S
    • 67730 S-Methylisothiourea hemisulfate salt purum, ≥98.0% (T) C2H6N2S · 0.5 H2SO4
    • M84445 S-Methylisothiourea hemisulfate salt 98% C2H6N2S · 0.5 H2SO4
    • 334677 2-Imino-4-thiobiuret 99% C2H6N4S
    • A22858 Acetylthiourea 99% C3H6N2OS
    • 03940 2-Imidazolidinethione purum, ≥98.0% (HPLC) C3H6N2S
    • 391964 1,2-Dimethyl-2-thiopseudourea hydriodide 98% C3H8N2S · HI
    • D188700 N,N′-Dimethylthiourea 99% C3H8N2S
    • 04890 N-Ethylthiourea purum, ≥98.0% (N) C3H8N2S
    • 252530 N-Ethylthiourea 99% C3H8N2S
    • A54601 2-(2-Aminoethyl)isothiourea dihydrobromide 99% C3H9N3S · 2HBr
    • CDS014146 n-prop-2-ynylurea AldrichCPR C4H6N2O
    • 06064 N-Allylthiourea purum, ≥98.0% (HPLC) C4H8N2S
    • 108804 N-Allylthiourea 98% C4H8N2S
    • CDS003516 1-(2-methoxyethyl)-2-thiourea AldrichCPR C4H10N2OS
    • CDS001177 N-Isopropylthiourea AldrichCPR C4H10N2S
    • CDS017065 (4-thioxo-[1,3,5]triazinan-1-yl)-acetic acid AldrichCPR C5H9N3O2S
    • D100900 N,N′-Diethylthiourea 98% C5H12N2S
    • 115169 Tetramethylthiourea 98% C5H12N2S
    • 466476 1,3-Bis(methoxycarbonyl)-2-methyl-2-thiopseudourea 97% C6H10N2O4S
    • 592765 N-Boc-thiourea 97% C6H12N2O2S
    • 598143 N-(2,4,6-Trichlorophenyl)thiourea 97% C7H5Cl3N2S
    • CDS003475 1-(2,3-dichlorophenyl)-2-thiourea AldrichCPR C7H6Cl2N2S
    • 197270 1-(3,4-Dichlorophenyl)-2-thiourea technical grade C7H6Cl2N2S
    • CDS001151 N-(3,5-Dichlorophenyl)thiourea AldrichCPR C7H6Cl2N2S
    • 654833 (2,3-Difluorophenyl)thiourea 97% C7H6F2N2S
    • 654841 (2,4-Difluorophenyl)thiourea 97% C7H6F2N2S
    • 654868 (2,5-Difluorophenyl)thiourea 97% C7H6F2N2S
    • 654876 (2,6-Difluorophenyl)thiourea 97% C7H6F2N2S
    • 586986 1-(2-Bromophenyl)-2-thiourea C7H7BrN2S
    • CDS004710 1-(3-bromophenyl)-2-thiourea AldrichCPR C7H7BrN2S
    • CDS003282 1-(4-chlorophenyl)-2-thiourea AldrichCPR C7H7ClN2S
    • CDS003641 (2-Fluorophenyl)thiourea AldrichCPR C7H7FN2S
    • 654825 (3-Fluorophenyl)thiourea 97% C7H7FN2S
    • 632945 (4-Fluorophenyl)thiourea 97% C7H7FN2S
    • CDS004474 1-(3-nitrophenyl)-2-thiourea AldrichCPR C7H7N3O2S
    • 199370 1-(4-Nitrophenyl)-2-thiourea 98% C7H7N3O2S
    • CDS001099 N-(2-Hydroxyphenyl)thiourea AldrichCPR C7H8N2OS
    • P7629 N-Phenylthiourea ≥98% C7H8N2S
    • P5272 N-Phenylthiourea Grade II, ≥90% (HPLC) C7H8N2S
    • 222909 N-Phenylthiourea 97% C7H8N2S
    • 79180 N-Phenylthiourea ≥95.0% (HPLC), purum C7H8N2S
    • D126802 1,3-Diisopropyl-2-thiourea 99% C7H16N2S
    • 654736 [4-Bromo-2-(trifluoromethyl)phenyl]thiourea 97% C8H6BrF3N2S
    • CDS000907 N-[4-Chloro-3-(trifluoromethyl)phenyl]thiourea AldrichCPR C8H6ClF3N2S
    • 632937 [3-(Trifluoromethyl)phenyl]thiourea 97% C8H7F3N2S
    • 654760 [4-(Trifluoromethyl)phenyl]thiourea 97% C8H7F3N2S
    • CDS001114 N-[2-(Trifluoromethyl)phenyl]thiourea AldrichCPR C8H7F3N2S
    • 654744 (4-Cyanophenyl)thiourea 97% C8H7N3S
    • CDS003990 1-(3-cyanophenyl)-2-thiourea AldrichCPR C8H7N3S
    • CDS014570 N-(2-cyanophenyl)thiourea AldrichCPR C8H7N3S
    • CDS004778 1-(3,4-Methylenedioxyphenyl)-2-thiourea AldrichCPR C8H8N2O2S
    • 560154 1-(3-Carboxyphenyl)-2-thiourea 96% C8H8N2O2S
    • CDS015865 N-(1H-indazol-5-yl)thiourea AldrichCPR C8H8N4S
    • CDS016621 N-(1H-indazol-6-yl)thiourea AldrichCPR C8H8N4S
    • CDS016630 N-(1H-indazol-7-yl)thiourea AldrichCPR C8H8N4S
    • CDS004649 2-bromo-4-methylphenylthiourea AldrichCPR C8H9BrN2S
    • CDS004653 4-bromo-2-methylphenylthiourea AldrichCPR C8H9BrN2S
    • CDS003408 5-chloro-2-methoxyphenylthiourea AldrichCPR C8H9ClN2OS
    • CDS003366 1-(3-chloro-2-methylphenyl)-2-thiourea AldrichCPR C8H9ClN2S
    • CDS003266 1-(3-chloro-4-methylphenyl)-2-thiourea AldrichCPR C8H9ClN2S
    • CDS003185 1-(5-chloro-2-methylphenyl)-2-thiourea AldrichCPR C8H9ClN2S
    • 361321 1-(2-Methoxyphenyl)-2-thiourea 99% C8H10N2OS
    • 251038 2-Benzyl-2-thiopseudourea hydrochloride 98% C8H10N2S · HCl
    • 13520 S-Benzylisothiourea hydrochloride purum, ≥98.0% (AT) C8H10N2S · HCl
    • CDS004475 (4-acetylphenyl)thiourea AldrichCPR C9H10N2OS
    • CDS003285 1-(3-acetylphenyl)-2-thiourea AldrichCPR C9H10N2OS
    • CDS008463 N-(4-thioureido-phenyl)-acetamide AldrichCPR C9H11N3OS
    • CDS004928 1-(3-methoxybenzyl)-2-thiourea AldrichCPR C9H12N2OS
    • CDS004522 1-(4-methoxybenzyl)-2-thiourea AldrichCPR C9H12N2OS
    • CDS001097 N-(2,4-Dimethoxyphenyl)thiourea AldrichCPR C9H12N2O2S
    • CDS001088 N-(2,5-Dimethoxyphenyl)thiourea AldrichCPR C9H12N2O2S
    • 654817 (3,5-Dimethylphenyl)thiourea 97% C9H12N2S
    • CDS003814 1-(2-ethylphenyl)-2-thiourea AldrichCPR C9H12N2S
    • CDS004517 1-(4-methylbenzyl)-2-thiourea AldrichCPR C9H12N2S
    • CBR01175 N-Benzyl-N-methylthiourea AldrichCPR C9H12N2S
    • CDS004712 1-[4-(dimethylamino)phenyl]-2-thiourea AldrichCPR C9H13N3S
    • D49598 N,N′-Dibutylthiourea 97% C9H20N2S
    • CDS004484 1-(3-ethoxycarbonylphenyl)-2-thiourea AldrichCPR C10H12N2O2S
    • CDS004518 1-(4-ethoxycarbonylphenyl)-2-thiourea AldrichCPR C10H12N2O2S
    • CDS011683 2,3-Dihydro-1H-inden-5-ylthiourea AldrichCPR C10H12N2S
    • 417009 S-(4,5-Dimethoxy-2-nitrobenzyl)isothiouronium bromide 97% C10H14BrN3O4S
    • CDS004798 1-(3-Phenylpropyl)-2-thiourea AldrichCPR C10H14N2S
    • CDS019017 5-Thioxo-1,4,5,6-tetrahydro-3H-furo[3,4-d][1,3]benzodiazepin-3-one AldrichCPR C11H8N2O2S
    • CDS018968 5-Phenyl-6-thioxo-1,5,6,7-tetrahydro-4H-pyrazolo[3,4-d]pyrimidin-4-one AldrichCPR C11H8N4OS
    • 531820 N,N′-Di-Boc-thiourea 97% C11H20N2O4S
    • CDS018966 8-Methoxy-5-thioxo-1,4,5,6-tetrahydro-3H-furo[3,4-d][1,3]benzodiazepin-3-one AldrichCPR C12H10N2O3S
    • CDS014930 1-(2-methylbut-3-yn-2-yl)-3-phenylurea AldrichCPR C12H14N2O
    • CDS011743 2-Mercapto-3-(3-methoxy-propyl)-3H-quinazolin-4-one AldrichCPR C12H14N2O2S
    • CDS001141 N-(4-Phenoxyphenyl)thiourea AldrichCPR C13H12N2OS
    • CDS019020 9-Ethoxy-5-thioxo-1,4,5,6-tetrahydro-3H-furo[3,4-d][1,3]benzodiazepin-3-one AldrichCPR C13H12N2O3S
    • T28355 N,N′-Diphenylthiourea 98% C13H12N2S
    • CDS011708 2-Mercapto-3-(2-methoxy-phenyl)-3H-quinazolin-4-one AldrichCPR C15H12N2O2S
    • 147109 1,3-Di-o-tolyl-2-thiourea 97% C15H16N2S
    • 131091 1,3-Di-p-tolyl-2-thiourea 97% C15H16N2S
    • CDS005262 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1R,2R)-(-)-2-(dimethylamino)cyclohexyl]thiourea AldrichCPR C17H21F6N3S
    • 458783 1,3-Bis(benzyloxycarbonyl)-2-methyl-2-thiopseudourea 95% C18H18N2O4S
    • 488631 2-Benzyl-1,3-bis(tert-butoxycarbonyl)-2-thiopseudourea 98% C18H26N2O4S