Piperidones

The piperidone pharmacophore, a nitrogen containing heterocycle, is a privileged structure, widely found in natural products, and displaying a broad-spectrum of biological actions. Piperidone derivatives possess a greater affinity towards cellular thiols than towards amino and hydroxyl groups; thus compounds of this nature may be devoid of the genotoxic side effects associated with many alkylating agents. As α,β-unsaturated ketones, these compounds are capable of undergoing Michael addition, resulting in alkylation of cellular nucleophiles. Piperidones exhibit anticancer, anti-inflammatory, and antimicrobial activity, and also inhibit the NF-κB signaling pathway. 2-Piperidone and 4-piperidone are important intermediates in alkaloid synthesis and in the preparation of medicinal agents. Mannich–Michael, and aza-Diels–Alder reactions involving an imino dienophile and a conjugated diene and enones have been applied to the synthesis of piperidine derivatives.

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Hayashi Catalysts

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Molecular Formula

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759368 2,4-Piperidinedione 97% C5H7NO2
    • CDS003223 4-piperidone AldrichCPR C5H9NO
    • 151769 4-Piperidone monohydrate hydrochloride 98% C5H9NO · HCl · H2O
    • CDS009156 (R)-4-hydroxy-piperidin-2-one AldrichCPR C5H9NO2
    • CDS010026 (S)-5-hydroxy-piperidin-2-one AldrichCPR C5H9NO2
    • CDS008167 4-hydroxy-2-piperidinone AldrichCPR C5H9NO2
    • CDS006090 3-piperidone hydrochloride AldrichCPR C5H10ClNO
    • CDS020573 (R)-3-Aminopiperidine-2-one AldrichCPR C5H10N2O
    • CDS017407 (R)-5-aminopiperidin-2-one AldrichCPR C5H10N2O
    • CDS019710 (S)-3-Aminopiperidine-2-one AldrichCPR C5H10N2O
    • CDS020148 3-Aminopiperidin-2-one AldrichCPR C5H10N2O
    • 757993 (S)-3-Amino-2-piperidone hydrochloride 95% C5H11ClN2O
    • CDS013956 (S)-5-Amino-piperidin-2-one hydrochloride AldrichCPR C5H11ClN2O
    • CBR01526 3-Amino-2-piperidinone hydrochloride AldrichCPR C5H11ClN2O
    • 80800 4-Piperidone hydrate hydrochloride purum, ≥98.0% (AT) C5H11NO2 · HCl
    • 529001 4-Hydroxy-6-methyl-3-nitro-2-pyridone 98% C6H6N2O4
    • CBR01770 2-Oxo-3-piperidinecarboxylic acid AldrichCPR C6H9NO3
    • CDS003761 6-oxo-pipecolinic acid AldrichCPR C6H9NO3
    • CDS011830 6-oxopiperidine-3-carboxylic acid AldrichCPR C6H9NO3
    • CDS012636 4-Oxo-1-piperidinecarboxamide AldrichCPR C6H10N2O2
    • M73788 N-Methyl-2-piperidone 99% C6H11NO
    • 130036 N-Methyl-4-piperidone 97% C6H11NO
    • CDS006657 1-(Methylsulfonyl)-4-piperidinone AldrichCPR C6H11NO3S
    • CDS018880 2-oxo-3-piperidinecarbohydrazide AldrichCPR C6H11N3O2
    • CDS019117 6-Aminomethyl-piperidin-2-one AldrichCPR C6H12N2O
    • 379409 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone 98% C7H9NO2
    • CDS001859 2-(2,6-Dioxo-1-piperidinyl)ethanesulfonyl chloride AldrichCPR C7H10ClNO4S
    • 388254 1-Acetyl-4-piperidone 94% C7H11NO2
    • CDS002691 (2-Oxo-1-piperidinyl)acetic acid AldrichCPR C7H11NO3
    • CDS007792 (4-oxo-piperidin-1-yl)-acetic acid hydrochloride AldrichCPR C7H12ClNO3
    • CDS004037 1,3-dimethyl-4-piperidone AldrichCPR C7H13NO
    • CDS000363 1,5-Dimethyl-2-piperidinone AldrichCPR C7H13NO
    • 130486 1-Ethyl-3-piperidone hydrochloride 97% C7H13NO · HCl
    • 279501 1-Ethyl-4-piperidone 98% C7H13NO
    • 178365 1,4-Dioxa-8-azaspiro[4.5]decane 98% C7H13NO2
    • 94532 1,4-Dioxa-8-azaspiro[4.5]decane hydrochloride puriss., ≥99.5% (T) C7H13NO2 · HCl
    • CBR01632 1-(Dimethylamino)-4-piperidinone AldrichCPR C7H14N2O
    • CDS014282 1-allyltetrahydro-4(1h)-pyridinone AldrichCPR C8H13NO
    • CBR00128 1-Ethyl-6-oxopiperidine-3-carboxylic acid AldrichCPR C8H13NO3
    • C5505 Ethyl 2-oxo-3-piperidinecarboxylate 99% C8H13NO3
    • 153737 Ethyl 4-oxo-1-piperidinecarboxylate 98% C8H13NO3
    • 555800 1-Oxa-4-azaspiro[4.5]decane 97% C8H15NO
    • 279498 1-Propyl-4-piperidone 98% C8H15NO
    • CDS004026 1-(5-bromopyrimidin-2-yl)-4-piperidinone AldrichCPR C9H10BrN3O
    • CDS004204 1-pyrimidin-2-yl-piperidin-4-one AldrichCPR C9H11N3O
    • CDS003682 1-N-alloc-4-piperidone AldrichCPR C9H13NO3
    • CBR00581 4-(2-Oxopiperidin-1-yl)butanoic acid AldrichCPR C9H15NO3
    • CBR00270 1-(2-Methoxyethyl)-6-oxopiperidine-3-carboxylic acid AldrichCPR C9H15NO4
    • 553190 1-(2-Methylpropyl)-4-piperidone 97% C9H17NO
    • CDS004525 1-butyl-4-piperidone AldrichCPR C9H17NO
    • 713406 1-tert-Butyl-4-piperidone 97% C9H17NO
    • 459119 2,2,6,6-Tetramethyl-4-piperidone 95% C9H17NO
    • 115762 2,2,6,6-Tetramethyl-4-piperidone hydrochloride 98% C9H17NO · HCl
    • 655775 1-(2-Hydroxyethyl)-4-piperidone ethylene ketal 97% C9H17NO3
    • CDS007874 7-bromo-1,2,3,4-tetrahydro-benzo[b]azepin-5-one AldrichCPR C10H10BrNO
    • CDS018073 1-[4-(trifluoromethyl)-2-pyrimidinyl]tetrahydro-4(1h)-pyridinone AldrichCPR C10H10F3N3O
    • CDS014819 1-(6-fluoro-2-pyridinyl)tetrahydro-4(1h)-pyridinone AldrichCPR C10H11FN2O
    • CDS012836 1-(pyridin-2-yl)piperidin-4-one AldrichCPR C10H12N2O
    • CDS012798 1-pyridin-4-ylpiperidin-4-one AldrichCPR C10H12N2O
    • CBR00537 1-(2-Furylmethyl)piperidin-4-one AldrichCPR C10H13NO2
    • CDS010677 1H-3-benzazepin-7-ol,2,3,4,5-tetrahydro-, hydrobromide (1:1) AldrichCPR C10H14BrNO
    • CDS003703 N-(4-piperidone)glutaramic acid AldrichCPR C10H15NO4
    • CDS015507 1-[(3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl]piperidin-4-one AldrichCPR C10H15N3O3S
    • CDS013001 1-(3-methyl-2-butenyl)-4-piperidinone AldrichCPR C10H17NO
    • 650811 1-Boc-3-piperidone 97% C10H17NO3
    • 15519 1-Boc-4-piperidone puriss., ≥99.0% (HPLC) C10H17NO3
    • 461350 1-Boc-4-piperidone 98% C10H17NO3
    • 688207 1-N-Boc-2-piperidone 97% C10H17NO3
    • 536903 1,2,2,6,6-Pentamethyl-4-piperidone 97% C10H19NO
    • CDS014197 1-isopentyltetrahydro-4(1h)-pyridinone AldrichCPR C10H19NO
    • CDS016406 1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]tetrahydro-4(1h)-pyridinone AldrichCPR C11H10ClF3N2O
    • CDS005474 1-(5-trifluoromethyl-2-pyridyl)-piperidin-4-one AldrichCPR C11H11F3N2O
    • CDS015349 1-(4-hydroxyphenyl)-2,6-piperidinedione AldrichCPR C11H11NO3
    • CDS008254 1-(3-bromophenyl)piperidin-4-one AldrichCPR C11H12BrNO
    • CDS007363 1-(4-bromophenylsulfonyl)piperidin-4-one AldrichCPR C11H12BrNO3S
    • CBR00535 1-(2-Chlorophenyl)piperidin-4-one AldrichCPR C11H12ClNO
    • CDS004393 1-(3-chloro-phenyl)-piperidin-4-one AldrichCPR C11H12ClNO
    • CDS018091 1-[(4-chlorophenyl)sulfonyl]tetrahydro-4(1h)-pyridinone AldrichCPR C11H12ClNO3S
    • CDS005741 1-(2-fluoro-phenyl)-piperidin-4-one AldrichCPR C11H12FNO
    • CDS014324 1-(2-aminophenyl)piperidine-2,6-dione AldrichCPR C11H12N2O2
    • CDS003657 6-(3-Pyridinylcarbonyl)valerolactam AldrichCPR C11H12N2O2
    • CDS011778 1-(3-aminophenyl)piperidin-2-one AldrichCPR C11H14N2O
    • CDS004218 1-pyridin-2-ylmethylpiperidin-4-one AldrichCPR C11H14N2O
    • CDS004246 1-pyridin-4-yl-methylpiperidin-4-one AldrichCPR C11H14N2O
    • CDS009041 1-Boc-2-trifluoromethyl-piperidin-4-one AldrichCPR C11H16F3NO3
    • CDS005883 1-cyclopentyl-6-oxopiperidine-3-carboxylic acid AldrichCPR C11H17NO3
    • CDS015186 4-Oxo-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester AldrichCPR C11H17NO5
    • CDS013824 1-cyclohexyl-4-piperidinone AldrichCPR C11H19NO
    • 00833 N-Boc-hexahydro-1H-azepin-4-one ≥95.0% (HPLC) C11H19NO3
    • CDS007289 1-(4-fluoro-benzoyl)-piperidin-4-one AldrichCPR C12H12FNO2
    • CDS008146 1-(3-trifluoromethylphenyl)-piperidin-4-one AldrichCPR C12H12F3NO
    • CDS005475 1-(4-trifluoromethylphenyl)-piperidin-4-one AldrichCPR C12H12F3NO
    • CDS011556 1-(2,6-dichloro-benzyl)-piperidin-4-one AldrichCPR C12H13Cl2NO
    • 107328 1-Benzoyl-4-piperidone 97% C12H13NO2
    • CDS006234 1-(1,3-benzodioxol-5-yl)piperidin-4-one AldrichCPR C12H13NO3
    • CDS012501 4-(2-oxopiperidin-1-yl)benzoic acid AldrichCPR C12H13NO3
    • CDS016784 4-(4-oxo-piperidin-1-yl)-benzoic acid AldrichCPR C12H13NO3
    • CDS015431 1-(1H-indazol-5-yl)piperidin-4-one AldrichCPR C12H13N3O
    • CDS012550 4-chlorobenzylpiperidone AldrichCPR C12H14ClNO
    • CDS010281 4-(4-oxo-piperidine-1-carbonyl)aniline AldrichCPR C12H14N2O2
    • CBR00485 1-(2-Methylphenyl)piperidin-4-one AldrichCPR C12H15NO
    • CDS005667 1-(3-methylphenyl)piperidin-4-one AldrichCPR C12H15NO
    • 496898 1-Benzyl-2-piperidone ≥98% C12H15NO
    • 13833 1-Benzyl-3-piperidone hydrochloride hydrate purum, ≥98.0% (AT) C12H15NO · HCl · xH2O
    • 153117 1-Benzyl-3-piperidone hydrochloride hydrate 95% C12H15NO · HCl · xH2O
    • B29806 1-Benzyl-4-piperidone 99% C12H15NO
    • CDS004881 1-p-Tolyl-piperidin-4-one AldrichCPR C12H15NO
    • CDS005668 1-(3-methoxy-phenyl)-piperidin-4-one AldrichCPR C12H15NO2
    • CDS006400 1-(4-methoxy-phenyl)-piperidin-4-one AldrichCPR C12H15NO2
    • CDS018554 1-(2-picolyl)-3-methyl-4-piperidinone AldrichCPR C12H16N2O
    • 757985 (S)-3-(Tosylamino)-2-piperidone 97% C12H16N2O3S
    • 370002 7,7,9,9-Tetramethyl-1,4-dioxa-8-azaspiro[4.5]decane-2-methanol ≥95% C12H23NO3
    • CDS002171 (2,6-Dioxo-4-phenyl-1-piperidinyl)acetic acid AldrichCPR C13H13NO4
    • CDS003459 N-(4′-carboxylic)benzoyl-4-piperidone AldrichCPR C13H13NO4
    • CDS004419 1-N-cbz-3-piperidone AldrichCPR C13H15NO3
    • 737534 1-Z-2-Piperidone 95% C13H15NO3
    • 464643 1-Z-4-Piperidone 99% C13H15NO3
    • CDS010875 1-[2-(4-fluorophenyl)ethyl]-4-piperidone AldrichCPR C13H16FNO
    • CDS008240 ethyl 6-(4-oxopiperidin-1-yl)nicotinate AldrichCPR C13H16N2O3
    • CDS004982 1-(2,3-dimethylphenyl)piperidin-4-one AldrichCPR C13H17NO
    • CDS004392 1-(3,5-dimethyl-phenyl)-piperidin-4-one AldrichCPR C13H17NO
    • 131385 1-Phenethyl-4-piperidone 98% C13H17NO
    • CDS004983 1-(2,3-Dihydro-1H-inden-5-yl)-4-piperidinone AldrichCPR C14H17NO
    • 227005 Methyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride 95% C14H17NO3 · HCl
    • CDS016633 1-[2-(benzyloxy)ethyl]tetrahydro-4(1h)-pyridinone AldrichCPR C14H19NO2
    • CDS002858 1-(2,6-Dimethoxybenzyl)-4-piperidinone AldrichCPR C14H19NO3
    • CDS009974 1-Boc-2-tert-Butyl-piperidin-4-one AldrichCPR C14H25NO3
    • CDS005393 1-alloc-2-phenylpiperidin-4-one AldrichCPR C15H17NO3
    • 143200 Ethyl 1-benzyl-3-oxo-4-piperidinecarboxylate hydrochloride technical grade C15H19NO3 · HCl
    • 495972 Ethyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride technical grade C15H19NO3 · HCl
    • CDS008252 1-(3-thiophen-3-yl-benzoyl)-piperidin-4-one AldrichCPR C16H15NO2S
    • CDS005405 1-alloc-2-benzylpiperidin-4-one AldrichCPR C16H19NO3
    • CDS008550 1-Boc-2-benzyl-piperidin-4-one AldrichCPR C17H23NO3
    • 47555 1-Fmoc-4-piperidone ≥98.0% (HPLC) C20H19NO3
    • 706639 N-Fmoc-3-piperidinone 97% C20H19NO3
    • 735582 (R)-1-Fmoc-4-oxopiperidine-2-carboxylic acid C21H19NO5
    • CDS008896 (3-([(9H-Fluoren-9-yl-methoxy)carbonyl]amino)-2-oxopiperidin-1-yl)acetic acid AldrichCPR C22H22N2O5