Pyrazoles

Pyrazole, a 5-membered heterocyclic diazole alkaloid composed of three carbon atoms and two nitrogen atoms in adjacent positions, is a prevalent scaffold in drug discovery programs. Derivatives of pyrazole are used for their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, tranquilizing, muscle relaxing, psychoanaleptic, anticonvulsant, monoamineoxidase inhibiting, antidiabetic and antibacterial activities. The pyrazole ring is present as the core in a variety of leading nonsteroidal anti-inflammatory drugs (NSAIDs) and antihypertensive drugs. They have also found use as bifunctional ligands for metal catalysis, and in various building blocks for pharmaceutical and agricultural research.

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