Pyridazines

Pyridazine, sometimes called 1,2-diazine, is a six-membered ring containing two adjacent nitrogen atoms. Pyridazine is a privileged structure in medicinal chemistry and can be used as an isosteric replacement of phenyl or heteroaromatic rings. Pyridazines can improve the physiochemical properties of drug molecules by increasing their water solubility, participating as hydrogen bond acceptors, and have a high capacity to complex with targets due to their dipole moment. Pyridazine confers bioavailability, especially to the CNS, and can reduce toxicity. Pyridazine is a part of several drug molecules, and the pyradzine pharmacophore has led to a variety of pharmacologically active compounds.

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738255 3,6-Dibromopyridazine 97% C4H2Br2N2
    • D73200 3,6-Dichloropyridazine 97% C4H2Cl2N2
    • 303097 4,5-Dichloro-3-hydroxypyridazine 98% C4H2Cl2N2O
    • 708364 3,6-Diiodopyridazine 97% C4H2I2N2
    • CDS020016 3-Amino-4-bromo-6-chloropyridazine AldrichCPR C4H3BrClN3
    • CDS006451 3-Chloropyridazine AldrichCPR C4H3ClN2
    • CDS012033 6-chloropyridazine-3-thiol AldrichCPR C4H3ClN2S
    • CDS015374 6-bromo-3-pyridazinamine AldrichCPR C4H4BrN3
    • P57204 Pyridazine 98% C4H4N2
    • 82685 3(2H)-Pyridazinone ≥97.0% (GC) C4H4N2O
    • 687642 Pyridazine N-oxide 97% C4H4N2O
    • D119806 Maleic hydrazide ReagentPlus®, 99% C4H4N2O2
    • 725048 3-Aminopyridazine 97% C4H5N3
    • CDS006078 4-aminopyridazine AldrichCPR C4H5N3
    • CDS005216 3-aminopyridazine hydrochloride AldrichCPR C4H6ClN3
    • 741272 3,6-Dichloro-4-(trifluoromethyl)pyridazine 95% C5HCl2F3N2
    • 297755 3,6-Dichloropyridazine-4-carboxylic acid 98% C5H2Cl2N2O2
    • 741280 3-(Trifluoromethyl)pyridazine 97% C5H3F3N2
    • 753718 Pyridazine-3-carbonitrile 97% C5H3N3
    • 297747 3,6-Dichloro-4-methylpyridazine 97% C5H4Cl2N2
    • 597716 4,5-Dichloro-2-methyl-3(2H)-pyridazinone 97% C5H4Cl2N2O
    • CDS007935 pyridazine-3-carbaldehyde AldrichCPR C5H4N2O
    • 297763 4-Pyridazinecarboxylic acid 97% C5H4N2O2
    • 755257 Pyridazine-3-carboxylic acid 97% C5H4N2O2
    • CDS006407 3-Chloro-5-methylpyridazine AldrichCPR C5H5ClN2
    • 637637 3-Chloro-6-methylpyridazine 97% C5H5ClN2
    • 108596 3-Chloro-6-methoxypyridazine 95% C5H5ClN2O
    • CDS006584 3-Amino-4-pyridazinecarboxylic acid AldrichCPR C5H5N3O2
    • 107239 3-Methylpyridazine 99% C5H6N2
    • 297771 4-Methylpyridazine 97% C5H6N2
    • CDS015970 3-hydroxymethylpyridazine AldrichCPR C5H6N2O
    • 668141 3,6-Dihydroxy-4-methylpyridazine 97% C5H6N2O2
    • CDS015149 6-oxo-1,6-dihydropyridazine-3-carboxylic acid monohydrate AldrichCPR C5H6N2O4
    • CDS005355 3-amino-6-methylpyridazine AldrichCPR C5H7N3
    • CDS019129 3-Aminomethylpyridazine AldrichCPR C5H7N3
    • CDS019328 4-Pyridazinemethanamine AldrichCPR C5H7N3
    • CDS007894 3-amino-6-methoxypyridazine AldrichCPR C5H7N3O
    • CDS013306 6-chloro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine AldrichCPR C6H2ClF3N4
    • CDS017428 4,7-Dichlorofuro[2,3-d]pyridazine AldrichCPR C6H2Cl2N2O
    • ANV00010 3-Bromo-6-chloroimidazo[1,2-b]pyridazine AldrichCPR C6H3BrClN3
    • L510904 6-Chloroimidazo[1,2-b]pyridazine AldrichCPR C6H4ClN3
    • CDS006141 3-chloro-6-methylpyridazine-4-carboxylic acid AldrichCPR C6H5ClN2O2
    • 730203 Methyl pyridazine-4-carboxylate 97% C6H6N2O2
    • CBR01301 (3,6-Dioxo-1,2,3,6-tetrahydropyridazin-4-yl)acetic acid AldrichCPR C6H6N2O4
    • CBR01607 6-Hydrazinoimidazo[1,2-b]pyridazine AldrichCPR C6H7N5
    • CDS005955 2-[(6-chloropyridazin-3-yl)amino]ethanol AldrichCPR C6H8ClN3O
    • CDS003940 3-Chloro-6-(4-iodo-1H-pyrazol-1-yl)pyridazine AldrichCPR C7H4ClIN4
    • CDS006021 3-Chloro-6-(1H-imidazol-1-yl)pyridazine AldrichCPR C7H5ClN4
    • CDS005778 3-Chloro-6-(1H-pyrazol-1-yl)pyridazine AldrichCPR C7H5ClN4
    • CDS002504 3,6-Dimethoxy-4-pyridazinecarboxylic acid AldrichCPR C7H8N2O4
    • CBR01162 3-(6-Oxo-1,4,5,6-tetrahydropyridazin-3-yl)propanoic acid AldrichCPR C7H10N2O3
    • 126020 1,4-Dichlorophthalazine 95% C8H4Cl2N2
    • P38706 Phthalazine 98% C8H6N2
    • P39001 Phthalazone 99% C8H6N2O
    • CDS008277 3-chloro-5-(1-pyrrolidinyl)pyridazine AldrichCPR C8H10ClN3
    • CDS004477 4-(6-chloro-pyridazin-3-yl)-morpholine AldrichCPR C8H10ClN3O
    • CDS020339 1-(6-Pyridazinyl)piperazine AldrichCPR C8H12N4
    • CDS014221 3-chloro-6-[(5-chloro-3-pyridyl)oxy]pyridazine AldrichCPR C9H5Cl2N3O
    • C82159 Cinnoline-4-carboxylic acid 97% C9H6N2O2
    • CDS001982 4-Oxo-3,4-dihydro-1-phthalazinecarboxylic acid AldrichCPR C9H6N2O3
    • CDS014944 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine AldrichCPR C9H9ClN4
    • CDS017723 (6-imidazol-1-yl-pyridazin-3-ylamino)-acetic acid AldrichCPR C9H9N5O2
    • CDS004245 1-(6-chloropyridazin-3-yl)piperidin-4-ol AldrichCPR C9H12ClN3O
    • 176842 1-Phenyl-4,5-dichloro-6-pyridazone ≥99% C10H6Cl2N2O
    • 342319 3-Chloro-6-phenylpyridazine 98% C10H7ClN2
    • CDS013502 6-chloro-4-hydroxy-3-phenyl-pyridazin AldrichCPR C10H7ClN2O
    • 510602 6-Phenyl-3(2H)-pyridazinone 98% C10H8N2O
    • 653578 6-(2-Hydroxyphenyl)-pyridazin-3(2H)-one 97% C10H8N2O2
    • 546305 6-(4-Bromophenyl)-4,5-dihydro-2H-pyridazin-3-one 97% C10H9BrN2O
    • CBR01164 3-(4-Chlorophenyl)-6-hydrazinopyridazine AldrichCPR C10H9ClN4
    • CDS004190 3-amino-6-phenylpyridazine AldrichCPR C10H9N3
    • CBR00023 3-Hydrazino-6-phenylpyridazine AldrichCPR C10H10N4
    • CDS014822 1-(6-chloro-3-pyridazinyl)-4-piperidinecarboxylic acid AldrichCPR C10H12ClN3O2
    • CDS011857 1-(6-chloropyridazin-3-yl)piperidine-3-carboxylic acid AldrichCPR C10H12ClN3O2
    • CDS001302 1-(6-Chloro-3-pyridazinyl)-4-piperidinecarboxamide AldrichCPR C10H13ClN4O
    • CDS017144 6-piperidin-1-ylpyridazine-3-carboxylic acid AldrichCPR C10H13N3O2
    • CDS013034 6-oxo-1-(2,3,5,6-tetrafluorophenyl)-1,4,5,6-tetrahydropyridazine-3-carboxylic acid AldrichCPR C11H6F4N2O3
    • CDS005644 3-(6-chloropyridazin-3-yl)benzoic acid AldrichCPR C11H7ClN2O2
    • CDS005432 4-(6-chloropyridazin-3-yl)benzoic acid AldrichCPR C11H7ClN2O2
    • CDS014116 1-(4-chlorophenyl)-4-oxo-1,4-dihydro-3-pyridazinecarboxylic acid AldrichCPR C11H7ClN2O3
    • CDS016856 1-(3-chlorophenyl)-4-hydroxy-6-oxo-1,6-dihydro-3-pyridazinecarboxylic acid AldrichCPR C11H7ClN2O4
    • CDS018245 3-amino-5-phenyl-4-pyridazinecarbonitrile AldrichCPR C11H8N4
    • CDS017245 3-benzyl-6-chloropyridazine AldrichCPR C11H9ClN2
    • CDS016313 allyl-(4-chloro-phthalazin-1-yl)-amine AldrichCPR C11H10ClN3
    • CDS017387 6-chloro-3-[4-(trifluoromethyl)phenyl]-1,2,4-triazolo[4,3-b]pyridazine AldrichCPR C12H6ClF3N4
    • CDS016860 2-(6-chloropyridazin-3-yl)-2-phenylacetonitrile AldrichCPR C12H8ClN3
    • CDS014975 3-(6-chloro-3-pyridazinyl)-1H-indole AldrichCPR C12H8ClN3
    • CDS012842 1-(2-chlorophenyl)-6-methyl-4-oxo-1,4-dihydropyridazine-3-carboxylic acid AldrichCPR C12H9ClN2O3
    • CDS018737 3-chloro-6-(3-methylbenzyl)pyridazine AldrichCPR C12H11ClN2
    • CDS013035 1-(3-chloro-4-methylphenyl)-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid AldrichCPR C12H11ClN2O3
    • CDS016559 4-Chloro-2-(3-chlorophenyl)-5-[(2-hydroxyethyl)amino]-3(2H)-pyridazinone AldrichCPR C12H11Cl2N3O2
    • CDS001322 3-Piperazin-1-yl-6-pyrrolidin-1-ylpyridazine AldrichCPR C12H19N5
    • CDS000789 6-Chloro-α-(3-methylphenyl)-3-pyridazineacetonitrile AldrichCPR C13H10ClN3
    • CDS018596 ethyl 3-chloro-6-phenyl-4-pyridazinecarboxylate AldrichCPR C13H11ClN2O2
    • CDS018668 2-(6-hydroxy-3-pyridazinyl)-2-(4-methoxyphenyl)acetic acid AldrichCPR C13H12N2O4
    • 534234 4-(4-Bromophenyl)-1(2H)-phthalazinone 97% C14H9BrN2O
    • 548820 4-(4-Chlorophenyl)-1-(2H)-phthalazinone 97% C14H9ClN2O
    • 525553 4-Phenyl-1-(2H)-phthalazinone 97% C14H10N2O
    • CDS016086 6-Phenyl-5-piperazino-3(2H)-pyridazinone AldrichCPR C14H16N4O
    • 713287 1,2-Di-Boc-piperidazine ≥98.0% (GC) C14H26N2O4
    • CDS009885 1-benzyl-4-chlorophthalazine AldrichCPR C15H11ClN2
    • 528080 (4-Methylphenyl)-1-(2H)-phthalazinone 95% C15H12N2O
    • 548839 4-(4-Methoxyphenyl)-1-(2H)-phthalazinone 98% C15H12N2O2
    • CDS007762 4-(tributylstannyl)pyridazine AldrichCPR C16H30N2Sn
    • CDS010157 (R)-(+)-4-[2-(diphenylphosphino)-1-naphthalenyl]-N-[(R)-1-phenylethyl]-1-phthalazinamine AldrichCPR C38H30N3P
    • JRD0220 2-(6-Chloropyridazin-3-yl)-2-(4-fluorophenyl)acetonitrile AldrichCPR New