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Pyrimidines are heterocyclic aromatic organic compounds similar to pyridine, but contain two nitrogen atoms at positions 1 and 3 of the six-membered ring. The ring is isomeric with two other forms of diazine: pyridazine, with the nitrogen atoms in positions 1 and 2; and pyrazine, with the nitrogen atoms in positions 1 and 4. As nucleotides in DNA and RNA, pyrimidine nucleotide derivatives have vast biological applications. For example, pyrimidine derivatives are of use in research on DNA repair with implications in cancer and epigenetics.