Coumarins

Coumarins are a group of plant-derived polyphenolic compounds. They belong to the benzopyrones family and possess a wide range of pharmaceutical applications including cytoprotective and modulatory functions, which may be translated into therapeutic potential for multiple diseases. Several natural and synthetic coumarins and derivatives, such as coumarin glycosides, possess potent biological activities. Coumarin derivatives are found in antibiotic, antimitotic, immunomodulating, antiviral, anticancer, anti-inflammatory, anticoagulant, antifungal, antioxidant, and cytotoxic agents, as well as some biological assays.

Coumarins have additional industrial applications. The fluorescence of coumarins, such as 7-hydroxycoumarin, is widely used as a research tool in polymer science. Coumarins are used as laser dye-sensitized photoinitiators, for incorporation into polymer chains by co-polymerization, in the estimation of polymer solvent effects, for various structural characterizations, in the monitoring of the releasing properties of poly(methylmethacrylate) nanospheres and for polymeric fluorescent solar collectors. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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Takasago Ligands

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CDS020271 5-Fluoro-2,3-dihydrobenzofuran AldrichCPR C8H7FO
513083 4-Chloro-3-nitrocoumarin 96% C9H4ClNO4
732990 7-Bromo-4-hydroxycoumarin C9H5BrO3
579572 3-Chlorocoumarin 97% C9H5ClO2
417343 6-Chloro-4-hydroxycoumarin 97% C9H5ClO3
CDS000898 6-Aminocoumarin hydrochloride AldrichCPR C9H8ClNO2
550361 6-Bromo-4-chloro-3-formylcoumarin 97% C10H4BrClO3
550353 4,6-Dichloro-3-formylcoumarin 97% C10H4Cl2O3
550337 4-Chloro-3-formylcoumarin 97% C10H5ClO3
640611 3-Chloro-7-hydroxy-4-methylcoumarin 97% C10H7ClO3
CDS007255 6-Chloro-7-hydroxy-4-methyl-2H-chromen-2-one AldrichCPR C10H7ClO3
550310 6-Bromo-3-cyano-4-methylcoumarin 97% C11H6BrNO2
579920 3-(Bromoacetyl)coumarin 97% C11H7BrO3
538590 3-Acetyl-6-bromocoumarin 97% C11H7BrO3
550345 4-Chloro-3-formyl-6-methylcoumarin 97% C11H7ClO3
235202 4-Bromomethyl-7-methoxycoumarin 97% C11H9BrO3
301450 4-Bromomethyl-6,7-dimethoxycoumarin 96% C12H11BrO4
173584 7-Acetoxy-6-(2,3-dibromopropyl)-4,8-dimethylcoumarin 97% C16H16Br2O4