Furans

Furans, consisting of a five-membered aromatic ring with one oxygen atom, are an important class of heterocyclic compounds that possess important biological properties. Considerable attention has been focused on the synthesis of furan derivatives and screening them for pharmacological activity. The furan ring system is the basic skeleton of numerous compounds possessing cardiovascular activities. An iodinated lipophilic furan derivative is widely used in the treatment of ventricular and arterial fibrillation. These moieties are widely found in antibacterial, antiviral, anti-inflammatory, antifungal, antitumor, antihyperglycemic analgesic, anticonvulsant, and other agents. Slight changes in substitution patterns in the furan nucleus cause distinguishable differences in their biological activities. Furan derivatives have been found to be inhibitors of biofilm formation for several bacterial species, as well as possess quorum-sensing inhibitory activities. In addition to being synthetic building blocks, 2-methylfuran and 2,5-dimethylfuran are promising lignocellulosic biofuels. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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Synthesis of Furans
BOX
Ring-Closing Metathesis

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Molecular Formula

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CDS000239 2,5-Dibromofuran AldrichCPR C4H2Br2O
719226 3,4-Dibromo-2(5H)-furanone 97% C4H2Br2O2
719242 3,4-Dichloro-2(5H)-furanone 97% C4H2Cl2O2
176524 3-Bromofuran 97% C4H3BrO
24700 3-Chloro-2,4(3H,5H)-furandione ≥98.0% (HPLC) C4H3ClO3
CDS017657 furan-2-sulfonyl chloride AldrichCPR C4H3ClO3S
CBR01676 cis-4-Aminotetrahydro-3-furanol hydrochloride AldrichCPR C4H10ClNO2
CDS017005 trans-4-Amino-tetrahydro-furan-3-ol hydrochloride AldrichCPR C4H10ClNO2
656291 4,5-Dibromo-2-furoic acid 97% C5H2Br2O3
CDS004540 3-bromo-2-formylfuran AldrichCPR C5H3BrO2
666599 4-Bromo-2-furaldehyde 97% C5H3BrO2
433985 5-Bromo-2-furaldehyde 97% C5H3BrO2
CDS015589 2-bromo-3-furoic acid AldrichCPR C5H3BrO3
777730 2-Bromofuran-3-carboxylic acid 96% C5H3BrO3
CDS006479 2-bromofuran-4-carboxylic acid AldrichCPR C5H3BrO3
B67406 5-Bromo-2-furoic acid 99% C5H3BrO3
531456 5-Chloro-2-furaldehyde 98% C5H3ClO2
CDS012743 5-chloro-2-furoic acid AldrichCPR C5H3ClO3
579289 5-Iodo-2-furaldehyde 97% C5H3IO2
677329 2-(Bromomethyl)-5-nitrofuran 97% C5H4BrNO3
CBR00909 2-Furancarboximidamide hydrochloride AldrichCPR C5H7ClN2O
736767 3-(Bromomethyl)tetrahydrofuran C5H9BrO
CDS001200 Tetrahydrofurfuryl bromide AldrichCPR C5H9BrO
722715 3-(Aminomethyl)tetrahydrofuran hydrochloride 95% C5H12ClNO
CBR00924 trans-4-(Methylamino)tetrahydro-3-furanol hydrochloride AldrichCPR C5H12ClNO2
CDS012268 1-(oxolan-3-ylmethyl)hydrazine dihydrochloride AldrichCPR C5H13ClN2O
CDS001439 5-Chlorobenzofuroxan AldrichCPR C6H3ClN2O2
CDS014856 5-(trifluoromethyl)-2-furaldehyde AldrichCPR C6H3F3O2
CDS007647 5-(trifluoromethyl)-3-furoic acid AldrichCPR C6H3F3O3
CDS014015 2-(bromomethyl)-5-(trifluoromethyl)furan AldrichCPR C6H4BrF3O
CFSS0001 2-(2,2-dibromovinyl)furan AldrichCPR C6H4Br2O
CDS016960 5-methyl-2-(trifluoromethyl)-3-furansulfonyl chloride AldrichCPR C6H4ClF3O3S
CDS017060 [5-(trifluoromethyl)-2-furyl]methylamine AldrichCPR C6H6F3NO
CDS015994 2,5-dimethyl-3-furansulfonyl chloride AldrichCPR C6H7ClO3S
CDS013888 5-methyl-2-(trifluoromethyl)furan-3-carbonyl chloride AldrichCPR C7H4ClF3O2
CBR00092 5-(5-Isoxazolyl)-2-furansulfonyl chloride AldrichCPR C7H4ClNO4S
CDS013890 5-methyl-2-(trifluoromethyl)-3-furoic acid AldrichCPR C7H5F3O3
CDS016465 [(5-bromo-furan-2-carbonyl)-amino]-acetic acid AldrichCPR C7H6BrNO4
541567 Methyl 5-(chloromethyl)-2-furoate 97% C7H7ClO3
CDS015219 methyl 5-(chlorosulfonyl)-2-methyl-3-furoate AldrichCPR C7H7ClO5S
CDS006205 2-Bromo-N-(2-furylmethyl)acetamide AldrichCPR C7H8BrNO2
CDS004387 5-Bromo-N,N-dimethyl-2-furamide AldrichCPR C7H8BrNO2
CDS008946 3-(5-Bromo-2-furyl)-β-alanine AldrichCPR C7H8BrNO3
CDS020079 5-(Chloromethyl)-N-methyl-2-furamide AldrichCPR C7H8ClNO2
CDS008339 6-Bromo-3H-isobenzofuran-1-one AldrichCPR C8H5BrO2
CDS015455 2-chloro-4-(2-furyl)pyrimidine AldrichCPR C8H5ClN2O
CDS008524 6-Chloro-3 H-isobenzofuran-1-one AldrichCPR C8H5ClO2
CDS018477 5-(2-furyl)-3-(trifluoromethyl)pyrazole AldrichCPR C8H5F3N2O
CDS009787 7-Amino-6-chloro-3H-isobenzofuran-1-one AldrichCPR C8H6ClNO2
CBR00135 5-(5-Isoxazolyl)-2-methyl-3-furansulfonyl chloride AldrichCPR C8H6ClNO4S
CDS020271 5-Fluoro-2,3-dihydrobenzofuran AldrichCPR C8H7FO
CDS016947 3-[(5-bromo-furan-2-carbonyl)-amino]-propionic acid AldrichCPR C8H8BrNO4
CBR00907 1-[5-(2-Furyl)-3-isoxazolyl]methanamine hydrochloride AldrichCPR C8H9ClN2O2
433993 Ethyl 5-(chloromethyl)-2-furancarboxylate 95% C8H9ClO3
CDS017717 methyl 4-(chlorosulfonyl)-2,5-dimethyl-3-furoate AldrichCPR C8H9ClO5S
CDS014896 5-fluoro-1-(R)-tetrahydro-furan-2-yl-1H-pyrimidine-2,4-dione AldrichCPR C8H9FN2O3
CDS005812 5-Bromo-N-isopropyl-2-furamide AldrichCPR C8H10BrNO2
CBR01366 2-Methyl-5-[5-(trifluoroMethyl)-3-isoxazolyl]-3-furansulfonyl chloride AldrichCPR C9H5ClF3NO4S
CDS007144 5-(4-chloro-pyrazol-1-ylmethyl)-furan-2-carboxylic acid AldrichCPR C9H7ClN2O3
CDS019165 4-(Chloromethyl)-2-furan-2-yl-5-methyloxazole AldrichCPR C9H8ClNO2
CBR01488 5-(3,4-Dimethyl-5-isoxazolyl)-2-furansulfonyl chloride AldrichCPR C9H8ClNO4S
CDS017466 3-(chloromethyl)-5-(2-furyl)-1-methyl-1H-pyrazole AldrichCPR C9H9ClN2O
CDS005767 1-(5-Bromo-2-furoyl)pyrrolidine AldrichCPR C9H10BrNO2
CDS014941 4-(5-bromo-2-furoyl)morpholine AldrichCPR C9H10BrNO3
CDS016521 ethyl 4-chlorosulphonyl-2,5-dimethyl-3-furoate AldrichCPR C9H11ClO5S
CDS013392 4-amino-1,1,1-trifluoro-2-(5-methyl-2-furyl)butan-2-ol AldrichCPR C9H12F3NO2
CBR01722 trans-4-(1-Piperidinyl)tetrahydro-3-furanamine dihydrochloride AldrichCPR C9H20Cl2N2O
CBR01564 trans-4-(4-Methyl-1-piperazinyl)tetrahydro-3-furanamine trihydrochloride AldrichCPR C9H22Cl3N3O
CDS014881 5-bromo-N-3-pyridinyl-2-furamide AldrichCPR C10H7BrN2O2
CDS015621 (2-[(5-bromo-2-furoyl)amino]-1,3-thiazol-4-yl)acetic acid AldrichCPR C10H7BrN2O4S
CDS020422 3-(2-Chlorophenyl)dihydro-2,5-furandione AldrichCPR C10H7ClO3
CDS020429 3-(3-Chloro-phenyl)-dihydro-furan-2,5-dione AldrichCPR C10H7ClO3
CDS020428 3-(4-Chloro-phenyl)-dihydro-furan-2,5-dione AldrichCPR C10H7ClO3
CDS020464 3-[(4-Chlorophenyl)sulfanyl]dihydro-2,5-furandione AldrichCPR C10H7ClO3S
CDS019379 3-(2-Fluoro-phenyl)-dihydro-furan-2,5-dione AldrichCPR C10H7FO3
CDS019376 3-(3-Fluoro-phenyl)-dihydro-furan-2,5-dione AldrichCPR C10H7FO3
CDS020399 3-(4-Fluorophenyl)dihydrofuran-2,5-dione AldrichCPR C10H7FO3
CDS015864 5-Amino-2-(4-fluorophenyl)-4-hydroxy-3(2H)-furanone AldrichCPR C10H8FNO3
CDS016814 4-(2-amino-4-chlorophenyl)-3-iminodihydro-2(3H)-furanone AldrichCPR C10H9ClN2O2
CBR00753 3-(2-Furyl)aniline hydrochloride AldrichCPR C10H10ClNO
CBR00754 4-(2-Furyl)aniline hydrochloride AldrichCPR C10H10ClNO
631221 5-(3,4-Dichlorophenyl)-2-furonitrile 97% C11H5Cl2NO
CDS006938 5-(4-Bromo-2-fluorophenyl)-2-furaldehyde AldrichCPR C11H6BrFO2
CDS016918 4-(4-bromophenyl)-2-oxo-2,5-dihydro-3-furancarbonitrile AldrichCPR C11H6BrNO2
CDS011332 5-(3-chloro-4-fluoro-phenyl)-furan-2-carbaldehyde AldrichCPR C11H6ClFO2
588903 5-(4-Chlorophenyl)-2-furonitrile 97% C11H6ClNO
CDS016692 4-(4-chlorophenyl)-2-oxo-2,5-dihydro-3-furancarbonitrile AldrichCPR C11H6ClNO2
567973 5-(4-Chloro-2-nitrophenyl)furfural 97% C11H6ClNO4
567981 5-(2,4-Dichlorophenyl)furfural 97% C11H6Cl2O2
568309 5-(2,5-Dichlorophenyl)furfural 96% C11H6Cl2O2
574112 5-(3,4-Dichlorophenyl)furfural 97% C11H6Cl2O2
574139 5-(2,4-Dichlorophenyl)-2-furoic acid 96% C11H6Cl2O3
588911 5-(2,5-Dichlorophenyl)-2-furoic acid 97% C11H6Cl2O3
592773 5-(3,4-Dichlorophenyl)-2-furoic acid 97% C11H6Cl2O3
CDS015084 5-(3,5-dichlorophenoxy)-2-furoic acid AldrichCPR C11H6Cl2O4
CDS011479 4-(4-fluorophenyl)-2-oxo-2,5-dihydro-3-furancarbonitrile AldrichCPR C11H6FNO2
CDS001694 5-(2,4-Difluoro-phenyl)-furan-2-carbaldehyde AldrichCPR C11H6F2O2
436925 5-(4-Bromophenyl)furfural 97% C11H7BrO2
568295 5-(4-Bromophenyl)-2-furoic acid 98% C11H7BrO3
428477 5-(2-Chlorophenyl)furfural 95% C11H7ClO2
428485 5-(3-Chlorophenyl)furfural 95% C11H7ClO2
428493 5-(4-Chlorophenyl)furfural 95% C11H7ClO2
428531 5-(4-Chlorophenyl)-2-furoic acid 97% C11H7ClO3
CDS006517 5-(2-fluoro-phenyl)-furan-2-carbaldehyde AldrichCPR C11H7FO2
CDS020112 5-(4-Fluoro-phenyl)-furan-2-carboxylic acid AldrichCPR C11H7FO3
CDS019108 N-(2,5-Dioxotetrahydro-3-furanyl)-4-fluorobenzamide AldrichCPR C11H8FNO4
CDS011673 furan-2-carboxylic acid (4-amino-2-chloro-phenyl)-amide AldrichCPR C11H9ClN2O2
CDS020438 3-(4-Chlorobenzyl)dihydrofuran-2,5-dione AldrichCPR C11H9ClO3
CDS009808 [5-(2-amino-4-chloro-phenyl)-furan-2-yl]-methanol AldrichCPR C11H10ClNO2
CDS002640 3-Fluoro-4-(2-furylmethoxy)aniline AldrichCPR C11H10FNO2
CDS006435 5-(4-chloro-3,5-dimethyl-pyrazol-1-ylmethyl)-furan-2-carboxylic acid AldrichCPR C11H11ClN2O3
CBR00765 1-(2-Furyl)-1-phenylmethanamine hydrochloride AldrichCPR C11H12ClNO
CDS001738 3-(5-Methyl-2-furyl)aniline hydrochloride AldrichCPR C11H12ClNO
CBR01109 1-(2-Furylmethyl)piperidine-3-carboxylic acid hydrochloride AldrichCPR C11H16ClNO3
CDS011632 5-(4-bromophenyl)-2-(trifluoromethyl)-3-furoic acid AldrichCPR C12H6BrF3O3
CDS016363 5-[2-chloro-4-(trifluoromethyl)phenyl]-2-furaldehyde AldrichCPR C12H6ClF3O2
447765 5-[2-Chloro-5-(trifluoromethyl)phenyl]furfural 97% C12H6ClF3O2
447846 5-[2-Chloro-5-(trifluoromethyl)phenyl]-2-furoic acid 96% C12H6ClF3O3
CDS001868 5-(4-Chlorophenyl)-2-(trifluoromethyl)furan-3-carboxylic acid AldrichCPR C12H6ClF3O3
CDS018437 5-[4-fluoro-3-(trifluoromethyl)phenyl]-2-furaldehyde AldrichCPR C12H6F4O2
CDS010430 2-chloro-5-(5-formyl-2-furyl)benzoic acid AldrichCPR C12H7ClO4
CDS010190 4-chloro-3-(5-formyl-furan-2-yl)-benzoic acid AldrichCPR C12H7ClO4
CDS019077 5-(4-Trifluoromethyl-phenyl)-furan-2-carboxylic acid AldrichCPR C12H7F3O3
CDS012746 2-(5-carboxyfurfurylthio)-5-(trifluoromethyl)pyridine AldrichCPR C12H8F3NO3S
CBR01461 5-(2-Bromo-4-methylphenyl)-2-furaldehyde AldrichCPR C12H9BrO2
CDS011737 5-(3-chloro-2-methylphenyl)-2-furaldehyde AldrichCPR C12H9ClO2
574120 5-(3-Chloro-4-methoxyphenyl)furfural 97% C12H9ClO3
CDS013635 5-(4-chlorophenyl)-2-methyl-3-furoic acid AldrichCPR C12H9ClO3
CDS005698 5-(2-chloro-phenoxymethyl)-furan-2-carboxylic acid AldrichCPR C12H9ClO4
CDS015539 5-(4-fluorophenyl)-2-methyl-3-furoic acid AldrichCPR C12H9FO3
CDS016041 5-(4-fluoro-phenoxymethyl)-furan-2-carboxylic acid AldrichCPR C12H9FO4
CDS014708 4-chloro-3-[(furan-2-ylmethyl)-sulfamoyl]-benzoic acid AldrichCPR C12H10ClNO5S
CDS011935 1-(5-(2-fluorophenyl)-2-furyl)-N-Methylmethanamine AldrichCPR C12H12FNO
CDS017517 1(5-bromo-2-hydroxyphenyl)-3(2-furyl)-prop-2-en-1-one AldrichCPR C13H9BrO3
CDS015619 2-[(5-bromo-2-furoyl)(methyl)amino]benzoic acid AldrichCPR C13H10BrNO4
CDS014891 1-[5-(4-chlorophenyl)-2-methyl-3-furyl]ethan-1-one AldrichCPR C13H11ClO2
CBR01190 3-(4-Fluorophenyl)-3-(2-furyl)propan-1-amine AldrichCPR C13H14FNO
CDS017897 (e)-1-(3-furyl)-3-[3-(trifluoromethyl)phenyl]-2-propen-1-one AldrichCPR C14H9F3O2
631213 3-[5-(4-Chlorophenyl)furan-2-yl]acrylic acid 97% C13H9CIO3
CDS011936 2-(((5-(3-chloro-4-methoxyphenyl)-2-furyl)methyl)amino)ethanol AldrichCPR C14H16ClNO3
CDS020595 3-Chloro-4-[4-(2-furoyl)piperazin-1-yl]aniline AldrichCPR C15H16ClN3O2
CDS002315 5-tert-Butyl-4-[(diethylamino)methyl]-2-methyl-3-furoic acid hydrochloride AldrichCPR C15H26ClNO3
CDS020508 5-[4-(2-Furoyl)-1-piperazinyl]-2-(trifluoromethyl)[1,6]naphthyridine AldrichCPR C18H15F3N4O2