Indoles

The indole subunit is a near-ubiquitous component of biologically active natural products, and its study has been a major focus of research for generations. Substituted indoles have frequently been referred to as privileged structures since they are capable of binding to multiple receptors with high affinity, and thus have applications across a wide range of therapeutic areas. Due to this activity, it is not surprising that the indole ring system has become an important building block or intermediate in the synthesis of many pharmaceutical agents. Notably, indole-3-carbinol, found in cruciferous vegetables, inhibits carcinogenesis at the initiation stage and has been shown to inhibit carcinogenesis in several animal species; but, it enhances tumor incidence if administered at a post-initiation stage. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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Indoles and Indole Isosteres

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702315 5-Bromo-3-chloro-7-azaindole 96% C7H4BrClN2
702307 5-Bromo-3-iodo-7-azaindole 97% C7H4BrIN2
694711 3-Bromo-7-azaindole 97% C7H5BrN2
703451 4-Bromo-7-azaindole 96% C7H5BrN2
692549 5-Bromo-7-azaindole 97% C7H5BrN2
732168 7-Bromo-6-azaindole 95% C7H5BrN2
692557 3-Chloro-7-azaindole 97% C7H5ClN2
696218 4-Chloro-7-azaindole 97% C7H5ClN2
692298 3-Iodo-7-azaindole 95% C7H5IN2
750379 5,7-Dibromoisatin 97% C8H3Br2NO2
597813 4,7-Dichloroisatin 97% C8H3Cl2NO2
633623 5,7-Dichloroisatin 97% C8H3Cl2NO2
476994 5-Bromoisatin technical grade, 90% C8H4BrNO2
CDS000133 6-Bromo-1H-indole-2,3-dione AldrichCPR C8H4BrNO2
679127 7-Bromoisatin 97% C8H4BrNO2
140562 5-Chloroisatin 97% C8H4ClNO2
CDS000344 6-Chloro-1H-indole-2,3-dione AldrichCPR C8H4ClNO2
675040 7-Chloroisatin 97% C8H4ClNO2
679119 7-Fluoroisatin 96% C8H4FNO2
140589 5-Iodoisatin technical grade C8H4INO2
691526 6-Bromo-5-fluoroindole 97% C8H5BrFN
701009 5-Bromo-7-iodoindole 97% C8H5BrIN
CDS001673 7-Bromo-5-nitro-1H-indole AldrichCPR C8H5BrN2O2
708798 5,7-Dibromoindole 97% C8H5Br2N
707120 5-Chloro-7-iodoindole 96% C8H5ClIN
CDS012113 6-chloro-2-oxoindoline-5-sulfonyl chloride AldrichCPR C8H5Cl2NO3S
707058 7-Fluoro-5-iodoindole 97% C8H5FIN
524336 4-Bromoindole 96% C8H6BrN
B68607 5-Bromoindole 99% C8H6BrN
524344 6-Bromoindole 96% C8H6BrN
473723 7-Bromoindole 96% C8H6BrN
CDS007620 4-bromooxindole AldrichCPR C8H6BrNO
CDS015822 5-bromo-1,2-dihydro-indol-3-one AldrichCPR C8H6BrNO
586552 5-Bromo-2-oxindole 97% C8H6BrNO
CDS009180 5-bromoisoindolin-1-one AldrichCPR C8H6BrNO
586595 6-Bromo-2-oxindole 97% C8H6BrNO
246220 4-Chloroindole 98% C8H6ClN
C47604 5-Chloroindole 98% C8H6ClN
246239 6-Chloroindole 99% C8H6ClN
473731 7-Chloroindole 97% C8H6ClN
127485 5-Chloro-2-oxindole 98% C8H6ClNO
636215 6-Chloro-2-oxindole 97% C8H6ClNO
691712 7-Chloro-2-oxindole 97% C8H6ClNO
CDS009777 2-oxoindoline-5-sulfonyl chloride AldrichCPR C8H6ClNO3S
740764 7-Fluoro-1H-indole 97% C8H6FN
CDS004944 6-fluorooxindole AldrichCPR C8H6FNO
CDS005460 7-fluorooxindole AldrichCPR C8H6FNO
563838 5-Iodoindole 97% C8H6IN
687766 7-Iodoindole 97% C8H6IN
CDS015232 7-amino-5-bromoindole AldrichCPR C8H7BrN2
760803 2-Chloro-3-methyl-7-azaindole 97% C8H7ClN2
CBR01431 3-Amino-7-chloro-1,3-dihydro-2H-indol-2-one hydrochloride AldrichCPR C8H8Cl2N2O
CDS009972 5-Fluoro-2,3-dihydro-1H-isoindole AldrichCPR C8H8FN
CBR00797 3-Amino-1,3-dihydro-2H-indol-2-one hydrochloride AldrichCPR C8H9ClN2O
737054 5-Aminooxindole hydrochloride C8H9ClN2O
CDS013933 4,5,6,7-tetrafluoroindole-3-carboxaldehyde AldrichCPR C9H3F4NO
754684 5,7-Dibromoindole-3-carboxaldehyde 97% C9H5Br2NO
766348 5-Chloro-7-iodoindole-3-carboxaldehyde 97% C9H5ClINO
CDS018831 4,6-dichloroindole-2-carboxylic acid AldrichCPR C9H5Cl2NO2
CDS010259 4,7-Dichloro-1H-indole-2-carboxylic acid AldrichCPR C9H5Cl2NO2
CDS007903 5,7-Dichloro-1H-indole-2-carboxylic acid AldrichCPR C9H5Cl2NO2
755400 7-Fluoro-5-iodoindole-3-carboxaldehyde 97% C9H5FINO
CDS003634 4-bromo-3-formylindole AldrichCPR C9H6BrNO
CDS018627 5-bromo-1H-indole-2-carbaldehyde AldrichCPR C9H6BrNO
518743 5-Bromoindole-3-carboxaldehyde 98% C9H6BrNO
CDS007625 6-Bromo-1H-indole-2-carbaldehyde AldrichCPR C9H6BrNO
666416 6-Bromoindole-3-carboxaldehyde 97% C9H6BrNO
754625 7-Bromoindole-3-carboxaldehyde 96% C9H6BrNO
CDS007486 3-bromoindole-2-carboxylic acid AldrichCPR C9H6BrNO2
CDS014882 4-bromo-5-methylisatin AldrichCPR C9H6BrNO2
B2761 5-Bromoindole-2-carboxylic acid C9H6BrNO2
CDS006283 6-bromoindole-2-carboxylic acid AldrichCPR C9H6BrNO2
CDS006684 3-Chloro-1H-indole-2-carbaldehyde AldrichCPR C9H6ClNO
CDS005229 4-chloroindole-3-carboxaldehyde AldrichCPR C9H6ClNO
CDS001754 5-Chloro-1H-indole-2-carbaldehyde AldrichCPR C9H6ClNO
533076 5-Chloroindole-3-carboxaldehyde 98% C9H6ClNO
CDS006409 5-Chloro-1H-indole-3-carboxylic acid AldrichCPR C9H6ClNO2
C47809 5-Chloroindole-2-carboxylic acid 98% C9H6ClNO2
CDS002296 7-Chloro-1H-indole-2-carboxylic acid AldrichCPR C9H6ClNO2
CDS005445 7-Chloro-1H-indole-3-carboxylic acid AldrichCPR C9H6ClNO2
CDS010754 2-methyl-1,3-dioxoisoindoline-5-sulfonyl chloride AldrichCPR C9H6ClNO4S
CDS002531 5-Fluoro-1H-indole-2-carbaldehyde AldrichCPR C9H6FNO
CDS007341 4-Fluoro-1H-indole-2-carboxylic acid AldrichCPR C9H6FNO2
CDS008236 5-fluoroindole-3-carboxylic acid AldrichCPR C9H6FNO2
CDS001751 7-Fluoro-1H-indole-2-carboxylic acid AldrichCPR C9H6FNO2
701068 5-(Trifluoromethyl)indole 97% C9H6F3N
CDS001039 6-(Trifluoromethyl)indole AldrichCPR C9H6F3N
CDS008597 5-(trifluoromethyl)oxindole AldrichCPR C9H6F3NO
CDS004860 6-trifluoromethyloxindole AldrichCPR C9H6F3NO
CDS010121 7-trifluoromethyloxindole AldrichCPR C9H6F3NO
CDS005068 5-(trifluoromethoxy)indolin-2-one AldrichCPR C9H6F3NO2
755370 7-Iodoindole-3-carboxaldehyde 97% C9H6INO
720860 4-Bromo-1-methylindole 95% C9H8BrN
718300 5-Bromo-1-methylindole 97% C9H8BrN
511528 5-Bromo-2-methylindole 98% C9H8BrN
752355 5-Bromo-3-methylindole 97% C9H8BrN
710822 5-Bromo-7-methylindole 97% C9H8BrN
707155 6-Bromo-7-methylindole 97% C9H8BrN
524867 7-Bromo-2-methylindole C9H8BrN
709654 7-Bromo-5-methylindole 96% C9H8BrN
CDS016352 5-bromo-1-methyl-2-oxoindoline AldrichCPR C9H8BrNO
736724 5-Bromo-2-(hydroxymethyl)indole 95% C9H8BrNO
CDS019787 1-Methyl-1H-indole-5-sulfonyl chloride AldrichCPR C9H8ClNO2S
707147 6-Fluoro-7-methylindole 97% C9H8FN
CDS009038 4-fluoro-5-hydroxy-2-methylindole AldrichCPR C9H8FNO
CDS002230 [(5-Chloro-1H-indol-2-yl)methyl]amine AldrichCPR C9H9ClN2
CDS007332 4-Cyano-isoindoline hydrochloride AldrichCPR C9H9ClN2
737070 2-(Aminomethyl)-5-fluoroindole 95% C9H9FN2
CDS002062 3-Amino-1-methyl-1,3-dihydro-2H-indol-2-one hydrochloride AldrichCPR C9H11ClN2O
CBR01051 3-Amino-1-methyl-1,3-dihydro-2H-indol-2-one hydrochloride hydrate AldrichCPR C9H13ClN2O2
CDS009598 5-Chloro-3-formyl-1H-indole-2-carboxylic acid AldrichCPR C10H6ClNO3
CDS002085 5-Fluoro-3-formyl-1H-indole-2-carboxylic acid AldrichCPR C10H6FNO3
CDS001618 7-(Trifluoromethyl)-1H-indole-2-carboxylic acid AldrichCPR C10H6F3NO2
CDS001670 5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid AldrichCPR C10H6F3NO3
759244 5-Bromo-7-methylindole-3-carboxaldehyde 97% C10H8BrNO
762520 6-Bromo-7-methylindole-3-carboxaldehyde 97% C10H8BrNO
776904 7-Acetyl-5-bromoindole 96% C10H8BrNO
754692 7-Bromo-5-methylindole-3-carboxaldehyde 97% C10H8BrNO
CDS011646 5-Bromo-3-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8BrNO2
B68720 5-Bromoindole-3-acetic acid 97% C10H8BrNO2
374210 5-Bromoindoxyl acetate 98% C10H8BrNO2
CDS001623 (6-Bromo-3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetic acid AldrichCPR C10H8BrNO3
CDS001878 5-Chloro-1-methyl-1H-indole-2-carbaldehyde AldrichCPR C10H8ClNO
CDS002271 4-Chloro-1-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8ClNO2
CDS002273 5-Chloro-1-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8ClNO2
CBR01647 6-Chloro-1-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8ClNO2
CDS001687 6-Chloro-7-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8ClNO2
CDS009232 5-Fluoro-2-methyl-1H-indole-3-carbaldehyde AldrichCPR C10H8FNO
CDS001923 5-Fluoro-3-methyl-1H-indole-2-carbaldehyde AldrichCPR C10H8FNO
CDS005636 6-Fluoro-1-methyl-1H-indole-3-carbaldehyde AldrichCPR C10H8FNO
CDS001938 6-Fluoro-7-methyl-1H-indole-2-carbaldehyde AldrichCPR C10H8FNO
CDS010794 5-Fluoro-1-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8FNO2
CDS008881 6-fluoroindole-3-acetic acid AldrichCPR C10H8FNO2
CDS002096 5-Fluoro-7-(methylsulfonyl)-1H-indole-2-carboxylic acid AldrichCPR C10H8FNO4S
CDS017040 2-(4-bromo-1H-indol-3-yl)acetamide AldrichCPR C10H9BrN2O
CDS017128 2-(7-bromo-1H-indol-3-yl)acetamide AldrichCPR C10H9BrN2O
CDS012538 5-bromoindole-3-acetamide AldrichCPR C10H9BrN2O
A6250 1-Acetyl-5-bromo-7-nitroindoline ≥98% C10H9BrN2O3
CDS017028 2-(5-chloro-1H-indol-3-yl)acetamide AldrichCPR C10H9ClN2O
CDS017130 2-(6-chloro-1H-indol-3-yl)acetamide AldrichCPR C10H9ClN2O
CDS017092 2-(7-chloro-1H-indol-3-yl)acetamide AldrichCPR C10H9ClN2O
CDS017041 2-(4-fluoro-1H-indol-3-yl)acetamide AldrichCPR C10H9FN2O
CDS017007 2-(5-fluoro-1H-indol-3-yl)acetamide AldrichCPR C10H9FN2O
CDS017139 2-(6-fluoro-1H-indol-3-yl)acetamide AldrichCPR C10H9FN2O
CDS017134 2-(7-fluoro-1H-indol-3-yl)acetamide AldrichCPR C10H9FN2O
376523 3-(2-Bromoethyl)indole 97% C10H10BrN
A6125 1-Acetyl-5-bromoindoline ≥99% C10H10BrNO
A6375 1-Acetyl-6-chloroindoline C10H10ClNO
CDS009259 5-chlorotryptophol AldrichCPR C10H10ClNO
CDS001786 [(6-Fluoro-7-methyl-1H-indol-2-yl)methyl]amine AldrichCPR C10H11FN2
CDS008022 5-fluorotryptamine AldrichCPR C10H11FN2
CDS009271 2-(5-Bromo-1H-indol-3-yl)ethanamine hydrochloride AldrichCPR C10H12BrClN2
CDS000212 2-(5-Chloro-1H-indol-3-yl)ethylamine hydrochloride AldrichCPR C10H12Cl2N2
CBR01432 3-Amino-5-ethyl-1,3-dihydro-2H-indol-2-one hydrochloride AldrichCPR C10H13ClN2O
CBR01137 2-(2,3-Dihydro-1H-indol-1-yl)ethanamine dihydrochloride AldrichCPR C10H16Cl2N2
CDS007837 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonyl chloride AldrichCPR C11H6ClNO3S
CDS008963 (5-Bromo-7-fluoro-2-methyl-1H-indol-3-yl)acetic acid AldrichCPR C11H9BrFNO2
724718 Ethyl 5-bromoindole-2-carboxylate 95% C11H10BrNO2
138096 Ethyl 5-chloro-2-indolecarboxylate 97% C11H10ClNO2
CDS008964 (5-Fluoro-2-methyl-1H-indol-3-yl)-acetic acid AldrichCPR C11H10FNO2
CDS005548 (7-Fluoro-2-methyl-1H-indol-3-yl)acetic acid AldrichCPR C11H10FNO2
B82707 5-Bromo-DL-tryptophan 99% C11H11BrN2O2
CDS018902 2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethanamine AldrichCPR C11H12Cl2N2
B5877 5-Bromogramine C11H13BrN2
CDS009009 2-(5-Chloro-1-methyl-1H-indol-3-yl)-ethylamine AldrichCPR C11H13ClN2
CDS002593 [(6-Fluoro-7-methyl-1H-indol-2-l)methyl]-methylamine AldrichCPR C11H13FN2
CBR00758 3-(1,3-Dihydro-2H-isoindol-2-yl)propanoic acid hydrochloride AldrichCPR C11H14ClNO2
CBR01048   6-Chloro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride hydrate AldrichCPR C11H14Cl2N2O
CBR01262 N-Methyl-1-(3-methyl-1H-indol-2-yl)methanamine hydrochloride AldrichCPR C11H15ClN2
CDS009702 (3-(2-Aminoethyl)-1-methylindole) dihydrochloride AldrichCPR C11H16Cl2N2
CDS014975 3-(6-chloro-3-pyridazinyl)-1H-indole AldrichCPR C12H8ClN3
139076 5-Bromo-4-chloroindoxyl 1,3-diacetate 98% C12H9BrClNO3
135062 5-Bromoindoxyl diacetate 99% C12H10BrNO3
CDS014397 Ethyl 2-(5-bromo-1H-indol-3-yl)-2-oxoacetate AldrichCPR C12H10BrNO3
CDS001784 6-Bromo-5-methoxy-1,2-dimethyl-1H-indole-3-carboxylic acid AldrichCPR C12H12BrNO3
CDS002406 5-Chloro-1-(2-methoxyethyl)-1H-indole-2-carboxylic acid AldrichCPR C12H12ClNO3
CBR00759 4-(1,3-Dihydro-2H-isoindol-2-yl)butanoic acid hydrochloride AldrichCPR C12H16ClNO2
CDS007005 2-(1,2-Dimethyl-1H-indol-3-yl)ethanamine hydrochloride AldrichCPR C12H17ClN2
CDS006850 4-(1-Piperazinyl)-1H-indole dihydrochloride AldrichCPR C12H17Cl2N3
CDS018169 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-1H-indole-3-carbaldehyde AldrichCPR C13H9ClN2OS
557749 N-Boc-5-bromoindole 97% C13H14BrNO2
636754 1-(tert-Butoxycarbonyl)-5-chloroindole 97% C13H14ClNO2
CDS015199 4-(1-indole)piperidine hydrochloride AldrichCPR C13H17ClN2
CDS003362 1-(2,6-dichlorophenyl)-2-indolinone AldrichCPR C14H9Cl2NO
633933 3-Bromo-(1-phenylsulfonyl)indole 95% C14H10BrNO2S
CDS013552 2-(4-chlorophenyl)indole AldrichCPR C14H10ClN
740101 N-Boc-2-bromo-3-methylindole 97% C14H16BrNO2
CBR01560 tert-Butyl 5-(aminomethyl)-1H-indole-1-carboxylate hydrochloride AldrichCPR C14H19ClN2O2
634050 5-Bromo-1-(tert-butyldimethylsilyl)-1H-indole 97% C14H20BrNSi
CBR01249 5-Chloro-3-phenyl-1H-indole-2-carboxylic acid AldrichCPR C15H10ClNO2
CDS014377 1-(Phenylsulfonyl)-1H-indole-3-carbonyl chloride AldrichCPR C15H10ClNO3S
CDS007569 H-Trp-OtBu hydrochloride AldrichCPR C15H21ClN2O2
CDS014823 2-(1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1H-indol-3-yl)acetamide AldrichCPR C16H11ClF3N3O
CDS004044 H-Trp-OBzl hydrochloride AldrichCPR C18H19ClN2O2
CDS020591 Fmoc-5-fluoro-DL-tryptophan AldrichCPR C26H21FN2O4