Indoles

The indole subunit is a near-ubiquitous component of biologically active natural products, and its study has been a major focus of research for generations. Substituted indoles have frequently been referred to as privileged structures since they are capable of binding to multiple receptors with high affinity, and thus have applications across a wide range of therapeutic areas. Due to this activity, it is not surprising that the indole ring system has become an important building block or intermediate in the synthesis of many pharmaceutical agents. Notably, indole-3-carbinol, found in cruciferous vegetables, inhibits carcinogenesis at the initiation stage and has been shown to inhibit carcinogenesis in several animal species; but, it enhances tumor incidence if administered at a post-initiation stage. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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Indoles and Indole Isosteres

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Molecular Formula

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702315 5-Bromo-3-chloro-7-azaindole 96% C7H4BrClN2
    • 702307 5-Bromo-3-iodo-7-azaindole 97% C7H4BrIN2
    • 694711 3-Bromo-7-azaindole 97% C7H5BrN2
    • 703451 4-Bromo-7-azaindole 96% C7H5BrN2
    • 692549 5-Bromo-7-azaindole 97% C7H5BrN2
    • 732168 7-Bromo-6-azaindole 95% C7H5BrN2
    • 692557 3-Chloro-7-azaindole 97% C7H5ClN2
    • 696218 4-Chloro-7-azaindole 97% C7H5ClN2
    • 692298 3-Iodo-7-azaindole 95% C7H5IN2
    • 750379 5,7-Dibromoisatin 97% C8H3Br2NO2
    • 597813 4,7-Dichloroisatin 97% C8H3Cl2NO2
    • 633623 5,7-Dichloroisatin 97% C8H3Cl2NO2
    • 476994 5-Bromoisatin technical grade, 90% C8H4BrNO2
    • CDS000133 6-Bromo-1H-indole-2,3-dione AldrichCPR C8H4BrNO2
    • 679127 7-Bromoisatin 97% C8H4BrNO2
    • 140562 5-Chloroisatin 97% C8H4ClNO2
    • CDS000344 6-Chloro-1H-indole-2,3-dione AldrichCPR C8H4ClNO2
    • 675040 7-Chloroisatin 97% C8H4ClNO2
    • 679119 7-Fluoroisatin 96% C8H4FNO2
    • 140589 5-Iodoisatin technical grade C8H4INO2
    • 691526 6-Bromo-5-fluoroindole 97% C8H5BrFN
    • 701009 5-Bromo-7-iodoindole 97% C8H5BrIN
    • CDS001673 7-Bromo-5-nitro-1H-indole AldrichCPR C8H5BrN2O2
    • 708798 5,7-Dibromoindole 97% C8H5Br2N
    • 707120 5-Chloro-7-iodoindole 96% C8H5ClIN
    • CDS012113 6-chloro-2-oxoindoline-5-sulfonyl chloride AldrichCPR C8H5Cl2NO3S
    • 707058 7-Fluoro-5-iodoindole 97% C8H5FIN
    • CDS002808 5,7-Difluoro-1,3-dihydro-2H-indol-2-one AldrichCPR C8H5F2NO
    • 524336 4-Bromoindole 96% C8H6BrN
    • B68607 5-Bromoindole 99% C8H6BrN
    • 524344 6-Bromoindole 96% C8H6BrN
    • 473723 7-Bromoindole 96% C8H6BrN
    • CDS007620 4-bromooxindole AldrichCPR C8H6BrNO
    • CDS015822 5-bromo-1,2-dihydro-indol-3-one AldrichCPR C8H6BrNO
    • 586552 5-Bromo-2-oxindole 97% C8H6BrNO
    • CDS009180 5-bromoisoindolin-1-one AldrichCPR C8H6BrNO
    • 586595 6-Bromo-2-oxindole 97% C8H6BrNO
    • 246220 4-Chloroindole 98% C8H6ClN
    • C47604 5-Chloroindole 98% C8H6ClN
    • 246239 6-Chloroindole 99% C8H6ClN
    • 473731 7-Chloroindole 97% C8H6ClN
    • 127485 5-Chloro-2-oxindole 98% C8H6ClNO
    • 636215 6-Chloro-2-oxindole 97% C8H6ClNO
    • 691712 7-Chloro-2-oxindole 97% C8H6ClNO
    • CDS009777 2-oxoindoline-5-sulfonyl chloride AldrichCPR C8H6ClNO3S
    • 740764 7-Fluoro-1H-indole 97% C8H6FN
    • CDS004944 6-fluorooxindole AldrichCPR C8H6FNO
    • CDS005460 7-fluorooxindole AldrichCPR C8H6FNO
    • 563838 5-Iodoindole 98% C8H6IN
    • 687766 7-Iodoindole 97% C8H6IN
    • CDS015232 7-amino-5-bromoindole AldrichCPR C8H7BrN2
    • 760803 2-Chloro-3-methyl-7-azaindole 97% C8H7ClN2
    • CBR01431 3-Amino-7-chloro-1,3-dihydro-2H-indol-2-one hydrochloride AldrichCPR C8H8Cl2N2O
    • CDS009972 5-Fluoro-2,3-dihydro-1H-isoindole AldrichCPR C8H8FN
    • CBR00797 3-Amino-1,3-dihydro-2H-indol-2-one hydrochloride AldrichCPR C8H9ClN2O
    • 737054 5-Aminooxindole hydrochloride C8H9ClN2O
    • CDS013933 4,5,6,7-tetrafluoroindole-3-carboxaldehyde AldrichCPR C9H3F4NO
    • 754684 5,7-Dibromoindole-3-carboxaldehyde 97% C9H5Br2NO
    • 766348 5-Chloro-7-iodoindole-3-carboxaldehyde 97% C9H5ClINO
    • CDS018831 4,6-dichloroindole-2-carboxylic acid AldrichCPR C9H5Cl2NO2
    • CDS010259 4,7-Dichloro-1H-indole-2-carboxylic acid AldrichCPR C9H5Cl2NO2
    • CDS007903 5,7-Dichloro-1H-indole-2-carboxylic acid AldrichCPR C9H5Cl2NO2
    • 755400 7-Fluoro-5-iodoindole-3-carboxaldehyde 97% C9H5FINO
    • CDS003634 4-bromo-3-formylindole AldrichCPR C9H6BrNO
    • CDS018627 5-bromo-1H-indole-2-carbaldehyde AldrichCPR C9H6BrNO
    • 518743 5-Bromoindole-3-carboxaldehyde 98% C9H6BrNO
    • CDS007625 6-Bromo-1H-indole-2-carbaldehyde AldrichCPR C9H6BrNO
    • 666416 6-Bromoindole-3-carboxaldehyde 97% C9H6BrNO
    • 754625 7-Bromoindole-3-carboxaldehyde 96% C9H6BrNO
    • CDS007486 3-bromoindole-2-carboxylic acid AldrichCPR C9H6BrNO2
    • CDS014882 4-bromo-5-methylisatin AldrichCPR C9H6BrNO2
    • B2761 5-Bromoindole-2-carboxylic acid C9H6BrNO2
    • CDS006283 6-bromoindole-2-carboxylic acid AldrichCPR C9H6BrNO2
    • CDS006684 3-Chloro-1H-indole-2-carbaldehyde AldrichCPR C9H6ClNO
    • CDS005229 4-chloroindole-3-carboxaldehyde AldrichCPR C9H6ClNO
    • CDS001754 5-Chloro-1H-indole-2-carbaldehyde AldrichCPR C9H6ClNO
    • 533076 5-Chloroindole-3-carboxaldehyde 98% C9H6ClNO
    • CDS006409 5-Chloro-1H-indole-3-carboxylic acid AldrichCPR C9H6ClNO2
    • C47809 5-Chloroindole-2-carboxylic acid 98% C9H6ClNO2
    • CDS002296 7-Chloro-1H-indole-2-carboxylic acid AldrichCPR C9H6ClNO2
    • CDS005445 7-Chloro-1H-indole-3-carboxylic acid AldrichCPR C9H6ClNO2
    • CDS010754 2-methyl-1,3-dioxoisoindoline-5-sulfonyl chloride AldrichCPR C9H6ClNO4S
    • CDS002531 5-Fluoro-1H-indole-2-carbaldehyde AldrichCPR C9H6FNO
    • CDS007341 4-Fluoro-1H-indole-2-carboxylic acid AldrichCPR C9H6FNO2
    • CDS008236 5-fluoroindole-3-carboxylic acid AldrichCPR C9H6FNO2
    • CDS001751 7-Fluoro-1H-indole-2-carboxylic acid AldrichCPR C9H6FNO2
    • 701068 5-(Trifluoromethyl)indole 97% C9H6F3N
    • CDS001039 6-(Trifluoromethyl)indole AldrichCPR C9H6F3N
    • CDS008597 5-(trifluoromethyl)oxindole AldrichCPR C9H6F3NO
    • CDS004860 6-trifluoromethyloxindole AldrichCPR C9H6F3NO
    • CDS010121 7-trifluoromethyloxindole AldrichCPR C9H6F3NO
    • CDS005068 5-(trifluoromethoxy)indolin-2-one AldrichCPR C9H6F3NO2
    • 755370 7-Iodoindole-3-carboxaldehyde 97% New C9H6INO
    • 720860 4-Bromo-1-methylindole 95% C9H8BrN
    • 718300 5-Bromo-1-methylindole 97% C9H8BrN
    • 511528 5-Bromo-2-methylindole 98% C9H8BrN
    • 752355 5-Bromo-3-methylindole 97% C9H8BrN
    • 710822 5-Bromo-7-methylindole 97% C9H8BrN
    • 707155 6-Bromo-7-methylindole 97% C9H8BrN
    • 524867 7-Bromo-2-methylindole 96% C9H8BrN
    • 709654 7-Bromo-5-methylindole 96% C9H8BrN
    • CDS016352 5-bromo-1-methyl-2-oxoindoline AldrichCPR C9H8BrNO
    • 736724 5-Bromo-2-(hydroxymethyl)indole 95% C9H8BrNO
    • CDS019787 1-Methyl-1H-indole-5-sulfonyl chloride AldrichCPR C9H8ClNO2S
    • 707147 6-Fluoro-7-methylindole 97% C9H8FN
    • CDS009038 4-fluoro-5-hydroxy-2-methylindole AldrichCPR C9H8FNO
    • CDS002230 [(5-Chloro-1H-indol-2-yl)methyl]amine AldrichCPR C9H9ClN2
    • CDS007332 4-Cyano-isoindoline hydrochloride AldrichCPR C9H9ClN2
    • 737070 2-(Aminomethyl)-5-fluoroindole 95% New C9H9FN2
    • CDS002062 3-Amino-1-methyl-1,3-dihydro-2H-indol-2-one hydrochloride AldrichCPR C9H11ClN2O
    • CBR01051 3-Amino-1-methyl-1,3-dihydro-2H-indol-2-one hydrochloride hydrate AldrichCPR C9H13ClN2O2
    • CDS010653 (5,6-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetic acid AldrichCPR C10H5Cl2NO4
    • CDS009882 (5-bromo-2,3-dioxo-2,3-dihydro-indol-1-yl)-acetic acid AldrichCPR C10H6BrNO4
    • CDS009598 5-Chloro-3-formyl-1H-indole-2-carboxylic acid AldrichCPR C10H6ClNO3
    • CDS002085 5-Fluoro-3-formyl-1H-indole-2-carboxylic acid AldrichCPR C10H6FNO3
    • CDS001618 7-(Trifluoromethyl)-1H-indole-2-carboxylic acid AldrichCPR C10H6F3NO2
    • CDS001670 5-(Trifluoromethoxy)-1H-indole-2-carboxylic acid AldrichCPR C10H6F3NO3
    • CDS017492 2-chloro-1-methyl-1H-indole-3-carbonitrile AldrichCPR C10H7ClN2
    • CDS004091 5-Bromo-1-methyl-1H-indole-3-carbaldehyde AldrichCPR C10H8BrNO
    • 759244 5-Bromo-7-methylindole-3-carboxaldehyde 97% C10H8BrNO
    • 762520 6-Bromo-7-methylindole-3-carboxaldehyde 97% C10H8BrNO
    • 776904 7-Acetyl-5-bromoindole 96% New C10H8BrNO
    • 754692 7-Bromo-5-methylindole-3-carboxaldehyde 97% C10H8BrNO
    • CDS011646 5-Bromo-3-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8BrNO2
    • B68720 5-Bromoindole-3-acetic acid 97% C10H8BrNO2
    • 374210 5-Bromoindoxyl acetate 98% C10H8BrNO2
    • CDS005592 7-Bromo-1,5-dimethyl-1H-indole-2,3-dione AldrichCPR C10H8BrNO2
    • CDS001623 (6-Bromo-3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetic acid AldrichCPR C10H8BrNO3
    • CDS001878 5-Chloro-1-methyl-1H-indole-2-carbaldehyde AldrichCPR C10H8ClNO
    • CDS002271 4-Chloro-1-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8ClNO2
    • CDS002273 5-Chloro-1-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8ClNO2
    • CBR01647 6-Chloro-1-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8ClNO2
    • CDS001687 6-Chloro-7-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8ClNO2
    • CDS009232 5-Fluoro-2-methyl-1H-indole-3-carbaldehyde AldrichCPR C10H8FNO
    • CDS001923 5-Fluoro-3-methyl-1H-indole-2-carbaldehyde AldrichCPR C10H8FNO
    • CDS005636 6-Fluoro-1-methyl-1H-indole-3-carbaldehyde AldrichCPR C10H8FNO
    • CDS001938 6-Fluoro-7-methyl-1H-indole-2-carbaldehyde AldrichCPR C10H8FNO
    • CDS010794 5-Fluoro-1-methyl-1H-indole-2-carboxylic acid AldrichCPR C10H8FNO2
    • CDS008881 6-fluoroindole-3-acetic acid AldrichCPR C10H8FNO2
    • CDS002096 5-Fluoro-7-(methylsulfonyl)-1H-indole-2-carboxylic acid AldrichCPR C10H8FNO4S
    • CDS017040 2-(4-bromo-1H-indol-3-yl)acetamide AldrichCPR C10H9BrN2O
    • CDS017128 2-(7-bromo-1H-indol-3-yl)acetamide AldrichCPR C10H9BrN2O
    • CDS012538 5-bromoindole-3-acetamide AldrichCPR C10H9BrN2O
    • A6250 1-Acetyl-5-bromo-7-nitroindoline ≥98% C10H9BrN2O3
    • CDS017028 2-(5-chloro-1H-indol-3-yl)acetamide AldrichCPR C10H9ClN2O
    • CDS017130 2-(6-chloro-1H-indol-3-yl)acetamide AldrichCPR C10H9ClN2O
    • CDS017092 2-(7-chloro-1H-indol-3-yl)acetamide AldrichCPR C10H9ClN2O
    • CDS017041 2-(4-fluoro-1H-indol-3-yl)acetamide AldrichCPR C10H9FN2O
    • CDS017007 2-(5-fluoro-1H-indol-3-yl)acetamide AldrichCPR C10H9FN2O
    • CDS017139 2-(6-fluoro-1H-indol-3-yl)acetamide AldrichCPR C10H9FN2O
    • CDS017134 2-(7-fluoro-1H-indol-3-yl)acetamide AldrichCPR C10H9FN2O
    • 376523 3-(2-Bromoethyl)indole 97% C10H10BrN
    • A6125 1-Acetyl-5-bromoindoline ≥99% C10H10BrNO
    • A6375 1-Acetyl-6-chloroindoline C10H10ClNO
    • CDS009259 5-chlorotryptophol AldrichCPR C10H10ClNO
    • ANV00144 Methyl 6-amino-1H-indole-4-carboxylate hydrochloride AldrichCPR C10H11ClN2O2
    • CDS010302 2-(4,6-Dichloro-1H-indol-3-yl)ethanamine hydrochloride AldrichCPR C10H11Cl3N2
    • CDS001786 [(6-Fluoro-7-methyl-1H-indol-2-yl)methyl]amine AldrichCPR C10H11FN2
    • CDS008022 5-fluorotryptamine AldrichCPR C10H11FN2
    • CDS009271 2-(5-Bromo-1H-indol-3-yl)ethanamine hydrochloride AldrichCPR C10H12BrClN2
    • CDS000212 2-(5-Chloro-1H-indol-3-yl)ethylamine hydrochloride AldrichCPR C10H12Cl2N2
    • CBR01432 3-Amino-5-ethyl-1,3-dihydro-2H-indol-2-one hydrochloride AldrichCPR C10H13ClN2O
    • CBR01137 2-(2,3-Dihydro-1H-indol-1-yl)ethanamine dihydrochloride AldrichCPR C10H16Cl2N2
    • CDS007837 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonyl chloride AldrichCPR C11H6ClNO3S
    • CDS010894 2-(5,6-dichloro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionic acid AldrichCPR C11H7Cl2NO4
    • CDS008963 (5-Bromo-7-fluoro-2-methyl-1H-indol-3-yl)acetic acid AldrichCPR C11H9BrFNO2
    • CDS007371 2-(5-Bromo-3-formyl-1H-indol-1-yl)acetamide AldrichCPR C11H9BrN2O2
    • CDS011783 (3-Bromo-2-methyl-1H-indol-1-yl)acetic acid AldrichCPR C11H10BrNO2
    • 724718 Ethyl 5-bromoindole-2-carboxylate 95% C11H10BrNO2
    • 138096 Ethyl 5-chloro-2-indolecarboxylate 97% C11H10ClNO2
    • CDS008964 (5-Fluoro-2-methyl-1H-indol-3-yl)-acetic acid AldrichCPR C11H10FNO2
    • CDS005548 (7-Fluoro-2-methyl-1H-indol-3-yl)acetic acid AldrichCPR C11H10FNO2
    • B82707 5-Bromo-DL-tryptophan 99% C11H11BrN2O2
    • CDS018902 2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethanamine AldrichCPR C11H12Cl2N2
    • B5877 5-Bromogramine C11H13BrN2
    • CDS009009 2-(5-Chloro-1-methyl-1H-indol-3-yl)-ethylamine AldrichCPR C11H13ClN2
    • CDS017075 2-[(3-chloro-1H-indol-2-ylmethyl)-amino]-ethanol AldrichCPR C11H13ClN2O
    • CDS002593 [(6-Fluoro-7-methyl-1H-indol-2-l)methyl]-methylamine AldrichCPR C11H13FN2
    • CBR00758 3-(1,3-Dihydro-2H-isoindol-2-yl)propanoic acid hydrochloride AldrichCPR C11H14ClNO2
    • CBR01048   6-Chloro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride hydrate AldrichCPR C11H14Cl2N2O
    • CBR01262 N-Methyl-1-(3-methyl-1H-indol-2-yl)methanamine hydrochloride AldrichCPR C11H15ClN2
    • CDS009702 (3-(2-Aminoethyl)-1-methylindole) dihydrochloride AldrichCPR C11H16Cl2N2
    • CDS014975 3-(6-chloro-3-pyridazinyl)-1H-indole AldrichCPR C12H8ClN3
    • 139076 5-Bromo-4-chloroindoxyl 1,3-diacetate 98% C12H9BrClNO3
    • 135062 5-Bromoindoxyl diacetate 99% C12H10BrNO3
    • CDS014397 Ethyl 2-(5-bromo-1H-indol-3-yl)-2-oxoacetate AldrichCPR C12H10BrNO3
    • CDS001872 1-Allyl-6-fluoro-1H-indole-3-carbaldehyde AldrichCPR C12H10FNO
    • CDS001784 6-Bromo-5-methoxy-1,2-dimethyl-1H-indole-3-carboxylic acid AldrichCPR C12H12BrNO3
    • CDS002406 5-Chloro-1-(2-methoxyethyl)-1H-indole-2-carboxylic acid AldrichCPR C12H12ClNO3
    • CBR00759 4-(1,3-Dihydro-2H-isoindol-2-yl)butanoic acid hydrochloride AldrichCPR C12H16ClNO2
    • CDS007005 2-(1,2-Dimethyl-1H-indol-3-yl)ethanamine hydrochloride AldrichCPR C12H17ClN2
    • CDS006850 4-(1-Piperazinyl)-1H-indole dihydrochloride AldrichCPR C12H17Cl2N3
    • CDS018169 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-1H-indole-3-carbaldehyde AldrichCPR C13H9ClN2OS
    • 557749 N-Boc-5-bromoindole 97% C13H14BrNO2
    • 636754 1-(tert-Butoxycarbonyl)-5-chloroindole 97% C13H14ClNO2
    • CDS015199 4-(1-indole)piperidine hydrochloride AldrichCPR C13H17ClN2
    • CDS002122 2,8-Dimethyl-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole dihydrochloride AldrichCPR C13H20Cl2N2
    • CDS003362 1-(2,6-dichlorophenyl)-2-indolinone AldrichCPR C14H9Cl2NO
    • 633933 3-Bromo-(1-phenylsulfonyl)indole 95% C14H10BrNO2S
    • CDS013552 2-(4-chlorophenyl)indole AldrichCPR C14H10ClN
    • 740101 N-Boc-2-bromo-3-methylindole 97% C14H16BrNO2
    • CBR01560 tert-Butyl 5-(aminomethyl)-1H-indole-1-carboxylate hydrochloride AldrichCPR C14H19ClN2O2
    • 634050 5-Bromo-1-(tert-butyldimethylsilyl)-1H-indole 97% C14H20BrNSi
    • CDS014692 2-(4-chlorophenyl)-1H-indole-3-carbaldehyde AldrichCPR C15H10ClNO
    • CBR01249 5-Chloro-3-phenyl-1H-indole-2-carboxylic acid AldrichCPR C15H10ClNO2
    • CDS014379 1-(Phenylsulfonyl)-1H-indole-2-carbonyl chloride AldrichCPR C15H10ClNO3S
    • CDS014377 1-(Phenylsulfonyl)-1H-indole-3-carbonyl chloride AldrichCPR C15H10ClNO3S
    • CDS007569 H-Trp-OtBu hydrochloride AldrichCPR C15H21ClN2O2
    • CDS014823 2-(1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1H-indol-3-yl)acetamide AldrichCPR C16H11ClF3N3O
    • CDS004044 H-Trp-OBzl hydrochloride AldrichCPR C18H19ClN2O2
    • CDS020591 Fmoc-5-fluoro-DL-tryptophan AldrichCPR C26H21FN2O4