Thiazolines/Thiazolidines

Thiazolines are five-membered heterocyclic compounds containing a sulfur atom and a nitrogen atom. Thiazolidine is the reduced form of thiazoline. Cysteine residues are commonly post-transcriptionally modified into thiazolines. Thiazoline derivatives are activators of PPARγ, which improves insulin resistance and lowers blood glucose levels in type 2 diabetes, as well as anticancer agents via inhibition of the Raf/MEK/extracellular signal regulated kinase (ERK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascades. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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441910 6-Bromo-2-benzothiazolinone 98% C7H4BrNOS