Thiophenes

Thiophenes (thiofurans) are important sulfur-containing heterocyclic compounds that function as analogues of furans and pyrroles, and are widely used as building blocks in many agrochemicals and pharmaceuticals as well as materials science. Benzothiophene and dibenzothiophene contain the thiophene ring fused with one and two benzene rings, respectively. As a consequence of its aromaticity, thiophene does not exhibit the same properties seen for conventional thioethers. For example, the sulfur atom in a thiophene resists alkylation and oxidation. Thiophene can also serve as a bioisostere of the benzene ring, such as in the NSAID lornoxicam, the thiophene analog of piroxicam. The presence of a halogen allows these reagents to be used as substrates in various coupling reactions, including Suzuki-Miyaura cross-coupling reactions.

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T5400 Tetrabromothiophene ReagentPlus®, 99% C4Br4S
131873 Tetrachlorothiophene 99% C4Cl4S
CDS002697 4-Bromo-5-chloro-2-thiophenesulfonyl chloride AldrichCPR C4HBrCl2O2S2
172758 2,3,5-Tribromothiophene 96% C4HBr3S
CDS014164 5-chloro-4-nitrothiophene-2-sulfonyl chloride AldrichCPR C4HCl2NO4S2
544280 2,5-Dichlorothiophene-3-sulfonyl chloride 97% C4HCl3O2S2
650285 4,5-Dichlorothiophene-2-sulfonyl chloride 97% C4HCl3O2S2
CDS014284 5-chlorothiophene-2,4-disulfonyl dichloride AldrichCPR C4HCl3O4S3
CDS017181 3-bromothiophene-2-sulphonyl chloride AldrichCPR C4H2BrClO2S2
636223 5-Bromothiophene-2-sulfonyl chloride 97% C4H2BrClO2S2
329762 2-Bromo-5-chlorothiophene 98% C4H2BrClS
544531 2-Bromo-5-nitrothiophene 97% C4H2BrNO2S
D43905 2,3-Dibromothiophene 97% C4H2Br2S
759325 2,4-Dibromothiophene C4H2Br2S
108472 2,5-Dibromothiophene 95% C4H2Br2S
247154 3,4-Dibromothiophene 99% C4H2Br2S
544272 5-Chlorothiophene-2-sulfonyl chloride 96% C4H2Cl2O2S2
650293 2,3-Dichlorothiophene C4H2Cl2S
D75807 2,5-Dichlorothiophene 98% C4H2Cl2S
331570 2,5-Diiodothiophene 98% C4H2I2S
124168 2-Bromothiophene 98% C4H3BrS
106224 3-Bromothiophene 97% C4H3BrS
155667 2-Chlorothiophene 96% C4H3ClS
341061 3-Chlorothiophene 98% C4H3ClS
542768 2,5-Dichlorothiophene-3-sulfonamide 97% C4H3Cl2NO2S2
651893 4,5-Dichlorothiophene-2-sulfonamide C4H3Cl2NO2S2
196150 2-Iodothiophene 98% C4H3IS
215023 3-Iodothiophene ≥97% C4H3IS
542741 5-Bromothiophene-2-sulfonamide 97% C4H4BrNO2S2
542695 5-Chlorothiophene-2-sulfonamide 97% C4H4ClNO2S2
CBR01142 3-Chloro-2,3-dihydrothiophene 1,1-dioxide AldrichCPR C4H5ClO2S
CDS005108 1,1-dioxo-2,5-dihydro-1H-1lambda6-thiophene-3-sulfonyl chloride AldrichCPR C4H5ClO4S2
CBR00934 (1,1-Dioxido-2,3-dihydro-3-thienyl)amine hydrochloride AldrichCPR C4H8ClNO2S
CBR00743 3-(Hydroxyamino)tetrahydrothiophene 1,1-dioxide hydrochloride AldrichCPR C4H10ClNO3S
CDS013861 4-bromo-2-thiophenecarbonyl chloride AldrichCPR C5H2BrClOS
CBR01152 4-Bromothiophene-3-carbonyl chloride AldrichCPR C5H2BrClOS
CDS003609 4-bromothiophene-2-carbonitrile AldrichCPR C5H2BrNS
731315 4-Bromothiophene-3-carbonitrile 97% C5H2BrNS
574430 5-Bromothiophene-2-carbonitrile 97% C5H2BrNS
764515 2,5-Dibromothiophene-3-carboxaldehyde 97% C5H2Br2OS
707090 3,4-Dibromothiophene-2-carboxaldehyde 97% C5H2Br2OS
753351 3,5-Dibromothiophene-2-carboxylic acid 95% C5H2Br2O2S
665983 5-Chloro-2-thiophenecarbonitrile 97% C5H2ClNS
CDS013694 3-chlorothiophene-2-carbonyl chloride AldrichCPR C5H2Cl2OS
654795 2,5-Dichlorothiophene-3-carboxylic acid 97% C5H2Cl2O2S
CDS015492 2-bromothiophene-3-carbaldehyde AldrichCPR C5H3BrOS
283452 4-Bromo-2-thiophenecarboxaldehyde 90% C5H3BrOS
152625 5-Bromo-2-thiophenecarboxaldehyde 95% C5H3BrOS
638129 2-Bromo-3-thiophenecarboxylic acid 97% C5H3BrO2S
633011 3-Bromothiophene-2-carboxylic acid 97% C5H3BrO2S
CDS006668 4-Bromo-2-thiophenecarboxylic acid AldrichCPR C5H3BrO2S
732214 4-Bromo-3-thiophenecarboxylic acid 97% C5H3BrO2S
467944 5-Bromo-2-thiophenecarboxylic acid 97% C5H3BrO2S
CDS013228 5-bromothiophene-3-carboxylic acid AldrichCPR C5H3BrO2S
443239 5-Chloro-2-thiophenecarboxaldehyde 97% C5H3ClOS
586994 3-Chlorothiophene-2-carboxylic acid 97% C5H3ClO2S
633003 5-Chlorothiophene-2-carboxylic acid 97% C5H3ClO2S
CBR01287 4-Bromo-2-thiophenecarboxamide AldrichCPR C5H4BrNOS
732222 4-Bromothiophene-3-carboxamide 97% C5H4BrNOS
CBR00204 5-Bromo-2-thiophenecarboxamide AldrichCPR C5H4BrNOS
700282 2,3-Dibromo-4-methylthiophene 97% C5H4Br2S
716375 2,5-Dibromo-3-methylthiophene 97% C5H4Br2S
692069 2-Bromo-3-(bromomethyl)thiophene 96% C5H4Br2S
668362 2,5-Dichloro-3-methylthiophene 96% C5H4Cl2S
241822 2-Chloro-5-(chloromethyl)thiophene 97% C5H4Cl2S
CDS016046 (4-bromo-2-thienyl)methanol AldrichCPR C5H5BrOS
CDS017501 (4-bromothien-3-yl)methanol AldrichCPR C5H5BrOS
337021 2-Bromo-3-methylthiophene 95% C5H5BrS
515485 2-Bromo-5-methylthiophene 95% C5H5BrS
474991 3-Bromo-4-methylthiophene 95% C5H5BrS
648728 4-Bromo-2-methylthiophene 97% C5H5BrS
678619 5-Chlorothiophene-2-carboxylic acid hydrazide 97% C5H5ClN2OS
648760 2-Chloro-3-methylthiophene 97% C5H5ClS
460532 2-Iodo-5-methylthiophene 97% C5H5IS
729248 3-(Aminomethyl)-2-bromothiophene 95% C5H6BrNS
CDS007961 5-bromothiophen-2-ylmethylamine AldrichCPR C5H6BrNS
CDS009279 (5-bromothien-2-yl)methylamine hydrochloride AldrichCPR C5H7BrClNS
CDS013426 (5-chlorothien-2-yl)methylamine hydrochloride AldrichCPR C5H7Cl2NS
CBR01534 (2-Thienylmethyl)hydrazine hydrochloride AldrichCPR C5H9ClN2S
CDS018688 4-chloro-tetrafluorothiophenol AldrichCPR C6HClF4S
CDS003660 2-bromo-5-trifluoroacetylthiophene AldrichCPR C6H2BrF3OS
696722 3,4-Dibromothiophene-2,5-dicarboxaldehyde 97% C6H2Br2O2S
694355 2-Amino-4-chloro-5-formyl-3-thiophenecarbonitrile 90% C6H3ClN2OS
708283 5-Fluoro-2,3-thiophenedicarboxaldehyde 97% C6H3FO2S
CDS014953 2-bromo-1-(3-chloro-2-thienyl)-1-ethanone AldrichCPR C6H4BrClOS
CDS003755 2-bromo-1-(5-chloro-thiophen-2-yl)-ethanone AldrichCPR C6H4BrClOS
CDS008079 2-bromo-4-fluorothiophenol AldrichCPR C6H4BrFS
CDS008156 3-bromo-4-fluorothiophenol AldrichCPR C6H4BrFS
CDS008206 4-bromo-2-fluorothiophenol AldrichCPR C6H4BrFS
CDS003130 (4-Bromo-thiophen-2-yl)-acetonitrile AldrichCPR C6H4BrNS
CFSS0002 2-(2,2-dibromovinyl)thiophene AldrichCPR C6H4Br2S
439509 3-Acetyl-2,5-dichlorothiophene 98% C6H4Cl2OS
CDS018953 3-chloro-4-methyl-2-thiophenecarbonyl chloride AldrichCPR C6H4Cl2OS
CDS014195 5-chloro-4-methoxythiophene-3-carbonyl chloride AldrichCPR C6H4Cl2O2S
CDS006949 methyl 5-chloro-3-chlorosulfonyl-2-thiophene carboxylate AldrichCPR C6H4Cl2O4S2
CDS011187 2,5-difluoro thiophenol AldrichCPR C6H4F2S
CDS003868 3,5-difluorothiophenol AldrichCPR C6H4F2S
CDS015413 1-(4-bromo-2-thienyl)-1-ethanone AldrichCPR C6H5BrOS
595594 2-(2-Bromoacetyl)thiophene 97% C6H5BrOS
633054 2-Acetyl-3-bromothiophene 97% C6H5BrOS
329738 2-Acetyl-5-bromothiophene 99% C6H5BrOS
CDS014416 2-bromo-1-(3-thienyl)-1-ethanone AldrichCPR C6H5BrOS
738336 3-(Bromoacetyl)thiophene 97% C6H5BrOS
776955 4-Bromo-3-methylthiophene-2-carboxaldehyde 97% C6H5BrOS
CDS008003 4-bromo-3-methylthiophenecarboxylic acid AldrichCPR C6H5BrO2S
CDS005911 methyl 4-bromothiophene-2-carboxylate AldrichCPR C6H5BrO2S
CDS000696 2-Acetyl-3-chlorothiophene AldrichCPR C6H5ClOS
CDS000671 2-Acetyl-4-chlorothiophene AldrichCPR C6H5ClOS
247073 2-Acetyl-5-chlorothiophene 99% C6H5ClOS
CDS009297 5-methyl-thiophene-2-carbonyl chloride AldrichCPR C6H5ClOS
CDS008860 thiophen-3-yl-acetyl chloride AldrichCPR C6H5ClOS
CDS006405 3-Chloro-4-methyl-2-thiophenecarboxylic acid AldrichCPR C6H5ClO2S
CDS015144 5-chloro-4-methoxythiophene-3-carboxylic acid AldrichCPR C6H5ClO3S
CDS017223 3-chloro-4-(methylsulfonyl)thiophene-2-carboxylic acid AldrichCPR C6H5ClO4S2
579637 2-Acetyl-5-iodothiophene 97% C6H5IOS
758221 (Z)-(5-Bromo-2-thienyl)ethanone oxime 97% C6H6BrNOS
CBR01581 5-[(Methylamino)carbonyl]-3-thiophenesulfonyl chloride AldrichCPR C6H6ClNO3S2
738298 2-Bromo-3,5-dimethylthiophene contains sodium bicarbonate as stabilizer, 96% C6H7BrS
749567 4-Bromo-2,3-dimethylthiophene 97% C6H7BrS
CDS011035 (5-bromo-thiophen-2-ylmethyl)-methyl-amine AldrichCPR C6H8BrNS
CDS017083 N-Methyl-(2-bromothien-3-yl)methylamine AldrichCPR C6H8BrNS
CBR01785 3-(2-Bromoethyl)tetrahydrothiophene 1,1-dioxide AldrichCPR C6H11BrO2S
CDS004813 4-trifluoromethyl-2,3,5,6-tetrafluorothiophenol AldrichCPR C7HF7S
CDS014754 2-bromo-5-(isoxazol-5-yl)thiophene AldrichCPR C7H4BrNOS
CBR01621 4-(5-Isoxazolyl)-2-thiophenesulfonyl chloride AldrichCPR C7H4ClNO3S2
CDS018204 4-(2,5-dichloro-3-thienyl)-1,3-thiazol-2-amine AldrichCPR C7H4Cl2N2S2
CDS017252 3-(5-bromo-2-thienyl)-1H-pyrazole AldrichCPR C7H5BrN2S
CDS012429 4-(3-bromo-2-thienyl)-1,3-thiazol-2-amine AldrichCPR C7H5BrN2S2
728667 trans-3-(4-Bromothiophen-2-yl)acrylic acid 97% C7H5BrO2S
CDS017253 3-(chloromethyl)-5-(3-thienyl)-1,2,4-oxadiazole AldrichCPR C7H5ClN2OS
CDS010845 5-(chloromethyl)-3-(2-thienyl)-1,2,4-oxadiazole AldrichCPR C7H5ClN2OS
CDS016354 3-(5-chloro-2-thienyl)pyrazole AldrichCPR C7H5ClN2S
CDS016607 4-(3-chloro-2-thienyl)-1,3-thiazol-2-amine AldrichCPR C7H5ClN2S2
CDS007567 4-(trifluoromethyl)thiophenol AldrichCPR C7H5F3S
CBR01166 1-(5-Bromo-2-thienyl)propan-1-one AldrichCPR C7H7BrOS
CDS006994 4-Bromo-5-ethyl-2-thiophenecarboxylic acid AldrichCPR C7H7BrO2S
CDS001116 Ethyl 5-bromo-2-thiophenecarboxylate AldrichCPR C7H7BrO2S
CBR01251 1-[4-(Chloromethyl)-2-thienyl]ethanone AldrichCPR C7H7ClOS
CDS013276 ([(5-chlorothien-2-yl)methyl]sulfonyl)acetic acid AldrichCPR C7H7ClO4S2
CDS003794 5-chloro-2-methylthiophenol AldrichCPR C7H7ClS
CDS003811 methyl 3-iodo-4-methylthiophene-2-carboxylate AldrichCPR C7H7IO2S
CDS006509 2-Bromo-N-(2-thienylmethyl)acetamide AldrichCPR C7H8BrNOS
CDS006813 D-2-(5-bromothienyl)alanine AldrichCPR C7H8BrNO2S
CDS016567 4-amino-4,5-dihydro-6h-cyclopenta[b]thiophen-6-one hydrochloride AldrichCPR C7H8ClNOS
CBR00942 (Methylamino)(2-thienyl)acetic acid hydrochloride AldrichCPR C7H10ClNO2S
CDS000990 DL-α-Amino-2-thiopheneacetic acid methyl ester hydrochloride AldrichCPR C7H10ClNO2S
CBR01263 N-Methyl-1-(2-thienyl)ethanamine hydrochloride AldrichCPR C7H12ClNS
CBR01050 2-(3-Methyl-2-thienyl)ethanamine hydrochloride hydrate AldrichCPR C7H14ClNOS
515493 5,5′-Dibromo-2,2′-bithiophene 99% C8H4Br2S2
CDS016974 2-(2-thienyl)-1,3-thiazole-4-carbonyl chloride AldrichCPR C8H4ClNOS2
522856 5-Bromo-2,2′-bithiophene 96% C8H5BrS2
CDS020042 4-(5-Bromo-2-thienyl)-2-methyl-1,3-thiazole AldrichCPR C8H6BrNS2
CDS017596 4-(5-bromo-2-thienyl)-2-pyrimidinamine AldrichCPR C8H6BrN3S
CDS018943 4-(5-chloro-2-thienyl)-2-pyrimidinamine AldrichCPR C8H6ClN3S
CDS010841 4-(5-chloro-2-thienyl)-4-oxobutyric acid AldrichCPR C8H7ClO3S
CDS012377 4-(5-bromothien-2-yl)butanoic acid AldrichCPR C8H9BrO2S
125016 4-Chloro-2′-butyrothienone 97% C8H9ClOS
CDS001033 2-(5-Chloro-2-thienyl)pyrrolidine AldrichCPR C8H10ClNS
CBR00838 4-Methyl-3-(2-thienyl)-1H-pyrazol-5-amine hydrochloride AldrichCPR C8H10ClN3S
CDS009476 2-(5-bromothiophen-2-yl)piperazine AldrichCPR C8H11BrN2S
CDS017020 1-[(5-chlorothien-2-yl)sulfonyl]piperazine AldrichCPR C8H11ClN2O2S2
CBR00906 1-(2-Thienyl)-1-butanamine hydrochloride AldrichCPR C8H14ClNS
777056 5′-Bromo-2,2′-bithiophene-5-carboxaldehyde 97% C9H5BrOS2
CDS000887 Benzo[b]thiophene-2-carbonyl chloride AldrichCPR C9H5ClOS
CDS014012 2,2′-bithiophene-5-carbonyl chloride AldrichCPR C9H5ClOS2
CDS014929 2-(5-bromo-2-thienyl)pyridine AldrichCPR C9H6BrNS
CDS019594 6-[5-(Trifluoromethyl)thiophen-3-yl]-1,2,3,4-tetrahydropyridazin-4-one AldrichCPR C9H7F3N2OS
CDS016613 4-(3-chloro-2-thienyl)-6-methyl-2-pyrimidinamine AldrichCPR C9H8ClN3S
CDS015422 1-[(5-chlorothien-2-yl)sulfonyl]pyrrolidine-2-carboxylic acid AldrichCPR C9H10ClNO4S2
CDS016618 5-tert-Butyl-thiophene-2-carbonyl chloride AldrichCPR C9H11ClOS
CDS009177 3-iodo-4-(isopropylsulfonyl)-5-(methylthio)-thiophene-2-carboxylic acid AldrichCPR C9H11IO4S3
762644 3-(Boc-amino)-2-bromothiophene 97% C9H12BrNO2S
CDS008370 6-(5-chloro-2-thienyl)nicotinaldehyde AldrichCPR C10H6ClNOS
CDS000825 2-(5-Chlorobenzo[b]thiophen-3-yl)acetonitrile AldrichCPR C10H6ClNS
CDS020035 2-(2-Bromophenyl)thiophene AldrichCPR C10H7BrS
596663 2-(4-Bromophenyl)thiophene 97% C10H7BrS
CDS016999 2-bromo-5-phenylthiophene AldrichCPR C10H7BrS
CDS001328 5-(Phenylsulphonyl)thiophene-2-sulphonyl chloride AldrichCPR C10H7ClO4S3
759708 2-[(Boc-amino)methyl]-5-bromothiophene 96% C10H14BrNO2S
CBR00781 Piperidin-3-yl(2-thienyl)methanone hydrochloride AldrichCPR C10H14ClNOS
764140 2-Bromo-4-hexylthiophene 97% C10H15BrS
694258 5-Bromo-2-hexylthiophene 97% C10H15BrS
CDS010245 5-[1-(5-chloro-thiophen-2-yl)-meth-(e)-ylidene]-3-prop-2-ynyl-thiazolidine-2,4-dione AldrichCPR C11H6ClNO2S2
CDS016515 2-fluoro-4-(3-thienyl)benzenecarbonitrile AldrichCPR C11H6FNS
CDS014009 4-(2-thienyl)benzoyl chloride AldrichCPR C11H7ClOS
CDS011721 5-(4-chlorophenyl)thiophene-2-carbaldehyde AldrichCPR C11H7ClOS
CDS002023 4-(4-Chlorophenyl)thiophene-2-carboxylic acid AldrichCPR C11H7ClO2S
CDS017320 4-[(4-chlorophenyl)thio]thiophene-3-carboxylic acid AldrichCPR C11H7ClO2S2
CDS018138 4-[(4-chlorophenyl)sulfonyl]-3-thiophenecarboxylic acid AldrichCPR C11H7ClO4S2
CDS001835 3-Amino-2-cyano-5-(4-fluorophenyl)thiophene AldrichCPR C11H7FN2S
CDS014162 4-fluorophenyl 2-thienyl ketone AldrichCPR C11H7FOS
CDS006076 5-(2-fluoro-phenyl)-thiophene-2-carbaldehyde AldrichCPR C11H7FOS
CDS012999 5-(4-fluoro-phenyl)-thiophene-2-carbaldehyde AldrichCPR C11H7FOS
649406 2-Amino-3-(4-bromobenzoyl)thiophene 97% C11H8BrNOS
649430 5-(4-Bromophenyl)thiophene-2-carboxylic hydrazide 95% C11H9BrN2OS
699098 5,5′′-Dibromo-2,2′:5′,2′′-terthiophene 97% C12H6Br2S3
CDS015259 4-[(4-chlorophenyl)sulfonyl]-3-methylthiophene-2-carboxylic acid AldrichCPR C12H9ClO4S2
CDS015080 3-[(4-fluorobenzyl)oxy]-2-thiophenecarboxylic acid AldrichCPR C12H9FO3S
CDS013513 methyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate AldrichCPR C12H10ClNO2S
CDS013083 N-(2-fluorophenyl)-2-(2-thienyl)ethanamide AldrichCPR C12H10FNOS
714550 2-Bromo-3-octylthiophene 97% C12H19BrS
CDS017969 3-(4-bromo-2-thienyl)-1-(4-chlorophenyl)prop-2-en-1-one AldrichCPR C13H8BrClOS
CDS017155 3-(3-chlorophenyl)-4-cyano-5-(methylthio)thiophene-2-carboxylic acid AldrichCPR C13H8ClNO2S2
CDS017481 (e)-3-(3-chlorophenyl)-1-(2-thienyl)-2-propen-1-one AldrichCPR C13H9ClOS
CDS014821 2-[5-(2-fluorobenzoyl)-2-thienyl]acetamide AldrichCPR C13H10FNO2S
CDS016085 2-[5-(4-fluorobenzoyl)-2-thienyl]acetamide AldrichCPR C13H10FNO2S
649384 Ethyl 3-amino-5-(4-chlorophenyl)thiophene-2-carboxylate 97% C13H12ClNO2S
CDS014926 3-(4-bromo-2-thienyl)-1-(4-chloro-3-methylphenyl)prop-2-en-1-one AldrichCPR C14H10BrClOS
CDS014491 1-(5-chloro-2-thienyl)-3-(4-methoxyphenyl)prop-2-en-1-one AldrichCPR C14H11ClO2S
CDS019162 5-Bromo-N-(1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboxamide AldrichCPR C14H13BrN2OS
739375 5-Bromo-5′-hexyl-2,2′-bithiophene 98% C14H17BrS2
688312 2-Bromo-3-dodecylthiophene 95% C16H27BrS
CDS019597 (2E)-4-{[4-(2,4-Dichlorophenyl)-3-(isopropoxycarbonyl)-2-thienyl]amino}-4-oxo-2-butenoic acid AldrichCPR C18H15Cl2NO5S
CDS019116 7-Chloro-4-[4-(2-thienylcarbonyl)-1-piperazinyl]quinoline AldrichCPR C18H16ClN3OS
CDS006677 Fmoc-D-2-(5-bromothienyl)alanine AldrichCPR C22H18BrNO4S