Thiophenes

Thiophenes (thiofurans) are important sulfur-containing heterocyclic compounds that function as analogues of furans and pyrroles, and are widely used as building blocks in many agrochemicals and pharmaceuticals as well as materials science. Benzothiophene and dibenzothiophene contain the thiophene ring fused with one and two benzene rings, respectively. As a consequence of its aromaticity, thiophene does not exhibit the same properties seen for conventional thioethers. For example, the sulfur atom in a thiophene resists alkylation and oxidation. Thiophene can also serve as a bioisostere of the benzene ring, such as in the NSAID lornoxicam, the thiophene analog of piroxicam.

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