Unnatural Amino Acid Derivatives

Unnatural amino acids are non-proteinogenic amino acids that either occur naturally or are chemically synthesized. Whether utilized as building blocks, conformational constraints, molecular scaffolds or pharmacologically active products, unnatural amino acids represent a nearly infinite array of diverse structural elements for the development of new leads in peptidic and non-peptidic compounds. Due to their seemingly unlimited structural diversity and functional versatility, they are widely used as chiral building blocks and molecular scaffolds in constructing combinatorial libraries.

Drug discovery has benefited from novel, short-chain peptide ligand mimetics (peptidomimetics) with both enhanced biological activity and proteolytic resistance. Used as molecular probes, they can help to better understand the function of biological systems. Optimized and fine-tuned analogues of peptidic substrates, inhibitors or effectors are also excellent analytical tools and molecular probes for investigating signal transduction pathways or gene regulation.

Our fast-growing, innovative line of unnatural amino acids includes:
  • β-amino acids (β3 and β2)
  • Homo-amino acids
  • Proline and Pyruvic acid derivatives
  • 3-substituted Alanine derivatives
  • Glycine derivatives
  • Ring-substituted Phenylalanine and Tyrosine Derivatives
  • Linear core amino acids
  • Diamino acids
  • D-amino acids
  • N-methyl amino acids

Sigma-Aldrich is committed to becoming a strong partner for your amino acid based research by offering a broad and unique range of unnatural amino acid building blocks, including derivatives of glycine, alanine, phenylalanine, and innovative α,α-disubstituted amino acids, as well as a comprehensive listing of proline derivatives and β-amino acids.

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Unnatural Amino Acids