Unnatural Amino Acids & Derivatives

Unnatural amino acids are non-proteinogenic amino acids that either occur naturally or are chemically synthesized. Whether utilized as building blocks, conformational constraints, molecular scaffolds or pharmacologically active products, unnatural amino acids represent a nearly infinite array of diverse structural elements for the development of new leads in peptidic and non-peptidic compounds. Due to their seemingly unlimited structural diversity and functional versatility, they are widely used as chiral building blocks and molecular scaffolds in constructing combinatorial libraries.

Drug discovery has benefited from novel, short-chain peptide ligand mimetics (peptidomimetics) with both enhanced biological activity and proteolytic resistance. Used as molecular probes, they can help to better understand the function of biological systems. Optimized and fine-tuned analogues of peptidic substrates, inhibitors or effectors are also excellent analytical tools and molecular probes for investigating signal transduction pathways or gene regulation.

Our fast-growing, innovative line of unnatural amino acids includes:
  • β-amino acids (β3 and β2)
  • Homo-amino acids
  • Proline and Pyruvic acid derivatives
  • 3-substituted Alanine derivatives
  • Glycine derivatives
  • Ring-substituted Phenylalanine and Tyrosine Derivatives
  • Linear core amino acids
  • N-methyl amino acids

Our collection also includes a diverse selection of unnatural amino acids with protecting groups such as Fmoc, Boc and Cbz. If you are looking for standard L- and D- amino acids including their protected forms or you are looking for amino alcohols, aldehydes, and lactones, please see: Amino Acids & Derivatives

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Unnatural Amino Acids